5Z1H
Crystal structure of the bacterial ribosomal decoding site in complex with 6'-fluoro sisomicin
Summary for 5Z1H
Entry DOI | 10.2210/pdb5z1h/pdb |
Descriptor | RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3'), (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(fluoromethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside (3 entities in total) |
Functional Keywords | rrna, aminoglycoside, rna |
Biological source | synthetic construct |
Total number of polymer chains | 2 |
Total formula weight | 15191.35 |
Authors | Kanazawa, H.,Hanessian, S.,Kondo, J. (deposition date: 2017-12-26, release date: 2018-05-30, Last modification date: 2024-03-27) |
Primary citation | Kanazawa, H.,Saavedra, O.M.,Maianti, J.P.,Young, S.A.,Izquierdo, L.,Smith, T.K.,Hanessian, S.,Kondo, J. Structure-Based Design of a Eukaryote-Selective Antiprotozoal Fluorinated Aminoglycoside. ChemMedChem, 13:1541-1548, 2018 Cited by PubMed: 29766661DOI: 10.1002/cmdc.201800166 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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