2OSB
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![BU of 2osb by Molmil](/molmil-images/mine/2osb) | Crystal structure of a thermostable mutant of Bacillus subtilis Adenylate Kinase (Q16L/Q199R/) | Descriptor: | Adenylate kinase, BIS(ADENOSINE)-5'-PENTAPHOSPHATE, MAGNESIUM ION, ... | Authors: | Myers, J, Counago, R, Wilson, C.J, Wu, G, Shamoo, Y. | Deposit date: | 2007-02-05 | Release date: | 2008-01-15 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of a thermostable mutant of Bacillus subtilis Adenylate Kinase (Q16L/Q199R/) To be Published
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8FMA
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![BU of 8fma by Molmil](/molmil-images/mine/8fma) | Nodavirus RNA replication proto-crown, detergent-solubliized C11 multimer | Descriptor: | RNA-directed RNA polymerase | Authors: | Zhan, H, Unchwaniwala, N, Rebolledo Viveros, A, Pennington, J, Horswill, M, Broadberry, R, Myers, J, den Boon, J, Grant, T, Ahlquist, P. | Deposit date: | 2022-12-22 | Release date: | 2023-02-01 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Nodavirus RNA replication crown architecture reveals proto-crown precursor and viral protein A conformational switching. Proc.Natl.Acad.Sci.USA, 120, 2023
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8FM9
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![BU of 8fm9 by Molmil](/molmil-images/mine/8fm9) | Nodavirus RNA replication proto-crown, detergent-solubliized C12 multimer | Descriptor: | RNA-directed RNA polymerase | Authors: | Zhan, H, Unchwaniwala, N, Rebolledo Viveros, A, Pennington, J, Horswill, M, Broadberry, R, Myers, J, den Boon, J, Grant, T, Ahlquist, P. | Deposit date: | 2022-12-22 | Release date: | 2023-02-01 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Nodavirus RNA replication crown architecture reveals proto-crown precursor and viral protein A conformational switching. Proc.Natl.Acad.Sci.USA, 120, 2023
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8FMB
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![BU of 8fmb by Molmil](/molmil-images/mine/8fmb) | Nodavirus RNA replication protein A polymerase domain, local refinement | Descriptor: | RNA-directed RNA polymerase | Authors: | Zhan, H, Unchwaniwala, N, Rebolledo Viveros, A, Pennington, J, Horswill, M, Broadberry, R, Myers, J, den Boon, J, Grant, T, Ahlquist, P. | Deposit date: | 2022-12-22 | Release date: | 2023-02-01 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (6.3 Å) | Cite: | Nodavirus RNA replication crown architecture reveals proto-crown precursor and viral protein A conformational switching. Proc.Natl.Acad.Sci.USA, 120, 2023
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2OC8
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![BU of 2oc8 by Molmil](/molmil-images/mine/2oc8) | Structure of Hepatitis C Viral NS3 protease domain complexed with NS4A peptide and ketoamide SCH503034 | Descriptor: | BETA-MERCAPTOETHANOL, Hepatitis C virus, ZINC ION, ... | Authors: | Prongay, A.J, Guo, Z, Yao, N, Fischmann, T, Strickland, C, Myers, J, Weber, P.C, Malcolm, B, Beyer, B.M, Ingram, R, Pichardo, J, Hong, Z, Prosise, W.W, Ramanathan, L, Taremi, S.S, Yarosh-Tomaine, T, Zhang, R, Senior, M, Yang, R.S, Arasappan, A, Bennett, F, Bogen, S.L, Chen, K, Jao, E, Liu, Y.T, Lovey, R.G, Saksena, A.K, Venkatraman, S, Girijavallabhan, V, Njoroge, F.G, Madison, V. | Deposit date: | 2006-12-20 | Release date: | 2007-07-31 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.66 Å) | Cite: | Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization. J.Med.Chem., 50, 2007
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2P3S
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![BU of 2p3s by Molmil](/molmil-images/mine/2p3s) | Crystal structure of a thermostable mutant of Bacillus subtilis Adenylate Kinase (G214R/Q199R) | Descriptor: | Adenylate kinase, BIS(ADENOSINE)-5'-PENTAPHOSPHATE, MAGNESIUM ION, ... | Authors: | Counago, R, Wilson, C.J, Myers, J, Wu, G, Shamoo, Y. | Deposit date: | 2007-03-09 | Release date: | 2008-01-22 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of a thermostable mutant of Bacillus subtilis Adenylate Kinase (G214R/Q199R) To be Published
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2ORI
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![BU of 2ori by Molmil](/molmil-images/mine/2ori) | Crystal structure of a thermostable mutant of Bacillus subtilis Adenylate Kinase (A193V/Q199R/) | Descriptor: | Adenylate kinase, BIS(ADENOSINE)-5'-PENTAPHOSPHATE, MAGNESIUM ION, ... | Authors: | Counago, R, Shamoo, Y, Wilson, C.J, Wu, G, Myers, J. | Deposit date: | 2007-02-02 | Release date: | 2008-01-15 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of a thermostable mutant of Bacillus subtilis Adenylate Kinase (A193V/Q199R/) To be Published
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2QAJ
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![BU of 2qaj by Molmil](/molmil-images/mine/2qaj) | Crystal structure of a thermostable mutant of Bacillus subtilis Adenylate Kinase (Q199R/G213E) | Descriptor: | Adenylate kinase, BIS(ADENOSINE)-5'-PENTAPHOSPHATE, MAGNESIUM ION, ... | Authors: | Counago, R, Wilson, C.J, Myers, J, Wu, G, Shamoo, Y. | Deposit date: | 2007-06-15 | Release date: | 2008-04-29 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of a thermostable mutant of Bacillus subtilis Adenylate Kinase (Q199R/G213E) To be Published
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5U6Y
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![BU of 5u6y by Molmil](/molmil-images/mine/5u6y) | Pseudo-atomic model of the CaMKIIa holoenzyme. | Descriptor: | Calcium/calmodulin-dependent protein kinase type II subunit alpha | Authors: | Myers, J, Reichow, S.L. | Deposit date: | 2016-12-09 | Release date: | 2017-06-21 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (20 Å) | Cite: | The CaMKII holoenzyme structure in activation-competent conformations. Nat Commun, 8, 2017
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5EJ2
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![BU of 5ej2 by Molmil](/molmil-images/mine/5ej2) | |
4LGV
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![BU of 4lgv by Molmil](/molmil-images/mine/4lgv) | |
4O2D
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![BU of 4o2d by Molmil](/molmil-images/mine/4o2d) | |
4OV6
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![BU of 4ov6 by Molmil](/molmil-images/mine/4ov6) | Crystal structure of PCSK9(53-451) with Adnectin | Descriptor: | 1,2-ETHANEDIOL, Adnectin, Proprotein convertase subtilisin/kexin type 9, ... | Authors: | Khan, J.A. | Deposit date: | 2014-02-20 | Release date: | 2014-07-02 | Last modified: | 2017-11-22 | Method: | X-RAY DIFFRACTION (2.69 Å) | Cite: | Pharmacologic Profile of the Adnectin BMS-962476, a Small Protein Biologic Alternative to PCSK9 Antibodies for Low-Density Lipoprotein Lowering. J.Pharmacol.Exp.Ther., 350, 2014
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3HZG
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![BU of 3hzg by Molmil](/molmil-images/mine/3hzg) | Crystal structure of mycobacterium tuberculosis thymidylate synthase X bound with FAD | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, PHOSPHATE ION, ... | Authors: | Staker, B.L, Rathod, P, Hunter, J, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | Deposit date: | 2009-06-23 | Release date: | 2009-07-07 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015
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3HE2
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![BU of 3he2 by Molmil](/molmil-images/mine/3he2) | |
3ICO
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![BU of 3ico by Molmil](/molmil-images/mine/3ico) | |
3KHP
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![BU of 3khp by Molmil](/molmil-images/mine/3khp) | |
3HWI
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![BU of 3hwi by Molmil](/molmil-images/mine/3hwi) | |
3HWK
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![BU of 3hwk by Molmil](/molmil-images/mine/3hwk) | |
3LLS
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![BU of 3lls by Molmil](/molmil-images/mine/3lls) | |
4HR3
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![BU of 4hr3 by Molmil](/molmil-images/mine/4hr3) | |
4I1Y
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![BU of 4i1y by Molmil](/molmil-images/mine/4i1y) | |
4IV6
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![BU of 4iv6 by Molmil](/molmil-images/mine/4iv6) | |
4J5I
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![BU of 4j5i by Molmil](/molmil-images/mine/4j5i) | |
4HDT
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![BU of 4hdt by Molmil](/molmil-images/mine/4hdt) | |