3HZG

Crystal structure of mycobacterium tuberculosis thymidylate synthase X bound with FAD

Summary for 3HZG

• Entry DOI: 10.2210/pdb3hzg/pdb
• Related: 3GWC
• Descriptor: Thymidylate synthase thyX, PHOSPHATE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... (5 entities in total)
• Functional Keywords: thyx, fad, thymidylate synthase, flavoprotein, methyltransferase, nucleotide biosynthesis, transferase, structural genomics, seattle structural genomics center for infectious disease, ssgcid
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 4
• Total formula weight: 119070.94

Authors

Staker, B.L.,Rathod, P.,Hunter, J.,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2009-06-23, release date: 2009-07-07, Last modification date: 2023-09-06)

• Primary citation: Baugh, L.,Phan, I.,Begley, D.W.,Clifton, M.C.,Armour, B.,Dranow, D.M.,Taylor, B.M.,Muruthi, M.M.,Abendroth, J.,Fairman, J.W.,Fox, D.,Dieterich, S.H.,Staker, B.L.,Gardberg, A.S.,Choi, R.,Hewitt, S.N.,Napuli, A.J.,Myers, J.,Barrett, L.K.,Zhang, Y.,Ferrell, M.,Mundt, E.,Thompkins, K.,Tran, N.,Lyons-Abbott, S.,Abramov, A.,Sekar, A.,Serbzhinskiy, D.,Lorimer, D.,Buchko, G.W.,Stacy, R.,Stewart, L.J.,Edwards, T.E.,Van Voorhis, W.C.,Myler, P.J.; Increasing the structural coverage of tuberculosis drug targets.; Tuberculosis (Edinb), 95:142-148, 2015; PubMed: 25613812; DOI: 10.1016/j.tube.2014.12.003

Experimental method

X-RAY DIFFRACTION (2.45 Å)