5X6F
 
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8UEC
 | | Structure of TREK-1CG*:CAT335a | | Descriptor: | CADMIUM ION, DECANE, HEXADECANE, ... | | Authors: | Mondal, A, Lee, H, Minor, D.L. | | Deposit date: | 2023-09-30 | | Release date: | 2024-06-26 | | Last modified: | 2025-01-08 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Development of covalent chemogenetic K 2P channel activators.
Cell Chem Biol, 31, 2024
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8UE2
 | | Structure of TREK-1CG*:ML335 | | Descriptor: | CADMIUM ION, DECANE, HEXADECANE, ... | | Authors: | Mondal, A, Lee, H, Minor, D.L. | | Deposit date: | 2023-09-29 | | Release date: | 2024-06-26 | | Last modified: | 2025-01-08 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Development of covalent chemogenetic K 2P channel activators.
Cell Chem Biol, 31, 2024
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8UE9
 | | Structure of TREK-1CG*:CAT335 | | Descriptor: | CADMIUM ION, HEXADECANE, N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)PALMITAMIDE, ... | | Authors: | Mondal, A, Lee, H, Minor, D.L. | | Deposit date: | 2023-09-29 | | Release date: | 2024-06-26 | | Last modified: | 2025-01-08 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Development of covalent chemogenetic K 2P channel activators.
Cell Chem Biol, 31, 2024
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9MRL
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9MRN
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9MRM
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9MRK
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8EOI
 | | Structure of a human EMC:human Cav1.2 channel complex in GDN detergent | | Descriptor: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Chen, Z, Mondal, A, Abderemane-Ali, F, Minor, D.L. | | Deposit date: | 2022-10-03 | | Release date: | 2023-05-24 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | EMC chaperone-Ca V structure reveals an ion channel assembly intermediate.
Nature, 619, 2023
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8EOG
 | | Structure of the human L-type voltage-gated calcium channel Cav1.2 complexed with L-leucine | | Descriptor: | (2R)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(dodecanoyloxy)propyl dodecanoate, (2R)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(dodecanoyloxy)propyl heptadecanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Chen, Z, Mondal, A, Abderemane-Ali, F, Minor, D.L. | | Deposit date: | 2022-10-03 | | Release date: | 2023-05-24 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | EMC chaperone-Ca V structure reveals an ion channel assembly intermediate.
Nature, 619, 2023
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8FD7
 | | Structure of the human L-type voltage-gated calcium channel Cav1.2 complexed with gabapentin | | Descriptor: | (2R)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(dodecanoyloxy)propyl heptadecanoate, (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(dodecanoyloxy)propyl dodecanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Chen, Z, Mondal, A, Minor, D.L. | | Deposit date: | 2022-12-02 | | Release date: | 2023-03-22 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural basis for Ca V alpha 2 delta :gabapentin binding.
Nat.Struct.Mol.Biol., 30, 2023
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8UF6
 | | Structure of Trek-1(K2P2.1) with ML336 | | Descriptor: | CADMIUM ION, DECANE, DODECANE, ... | | Authors: | Lolicato, M, Mondal, A, Minor, D.L. | | Deposit date: | 2023-10-03 | | Release date: | 2024-06-26 | | Last modified: | 2025-01-08 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Development of covalent chemogenetic K 2P channel activators.
Cell Chem Biol, 31, 2024
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6JNP
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9DHR
 | | Glutamate activated state of the GluA2-gamma2 complex | | Descriptor: | GLUTAMIC ACID, Isoform Flip of Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit | | Authors: | Kumar Mondal, A, Carrillo, E, Jayaraman, V, Twomey, E.C. | | Deposit date: | 2024-09-04 | | Release date: | 2025-03-26 | | Last modified: | 2025-05-21 | | Method: | ELECTRON MICROSCOPY (3.54 Å) | | Cite: | Glutamate gating of AMPA-subtype iGluRs at physiological temperatures.
Nature, 641, 2025
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9DHP
 | | Resting state 1 of the GluA2-gamma2 complex | | Descriptor: | Isoform Flip of Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit | | Authors: | Kumar Mondal, A, Carrillo, E, Jayaraman, V, Twomey, E.C. | | Deposit date: | 2024-09-04 | | Release date: | 2025-03-26 | | Last modified: | 2025-05-21 | | Method: | ELECTRON MICROSCOPY (4.18 Å) | | Cite: | Glutamate gating of AMPA-subtype iGluRs at physiological temperatures.
Nature, 641, 2025
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9DHQ
 | | Resting state 2 of the GluA2-gamma2 complex | | Descriptor: | Isoform Flip of Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit | | Authors: | Kumar Mondal, A, Carrillo, E, Jayaraman, V, Twomey, E.C. | | Deposit date: | 2024-09-04 | | Release date: | 2025-03-26 | | Last modified: | 2025-05-28 | | Method: | ELECTRON MICROSCOPY (4.78 Å) | | Cite: | Glutamate gating of AMPA-subtype iGluRs at physiological temperatures.
Nature, 641, 2025
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9DHT
 | | Desensitized state 2 of the GluA2-gamma2 complex | | Descriptor: | GLUTAMIC ACID, Isoform Flip of Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit | | Authors: | Kumar Mondal, A, Carrillo, E, Jayaraman, V, Twomey, E.C. | | Deposit date: | 2024-09-04 | | Release date: | 2025-03-26 | | Last modified: | 2025-05-21 | | Method: | ELECTRON MICROSCOPY (4.31 Å) | | Cite: | Glutamate gating of AMPA-subtype iGluRs at physiological temperatures.
Nature, 641, 2025
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9DHS
 | | Desensitized state 1 of the GluA2-gamma2 complex | | Descriptor: | GLUTAMIC ACID, Isoform Flip of Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit | | Authors: | Kumar Mondal, A, Carrillo, E, Jayaraman, V, Twomey, E.C. | | Deposit date: | 2024-09-04 | | Release date: | 2025-03-26 | | Last modified: | 2025-05-21 | | Method: | ELECTRON MICROSCOPY (4.48 Å) | | Cite: | Glutamate gating of AMPA-subtype iGluRs at physiological temperatures.
Nature, 641, 2025
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4RUK
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3X1J
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3X1M
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3X1K
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