5WA8
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![BU of 5wa8 by Molmil](/molmil-images/mine/5wa8) | Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) H112N mutant nucleoside L-Ala phosphoramidate substrate complex | Descriptor: | CHLORIDE ION, Histidine triad nucleotide-binding protein 1, [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-~{N}-[(2~{S})-1-methoxy-1-oxidanylidene-propan-2-yl]phosphonamidic acid | Authors: | Maize, K.M, Finzel, B.C. | Deposit date: | 2017-06-26 | Release date: | 2017-10-18 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | A Crystal Structure Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides. Mol. Pharm., 14, 2017
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5WA9
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![BU of 5wa9 by Molmil](/molmil-images/mine/5wa9) | Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) H112N mutant nucleoside D-Ala phosphoramidate substrate complex | Descriptor: | CHLORIDE ION, Histidine triad nucleotide-binding protein 1, [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-~{N}-[(2~{R})-1-methoxy-1-oxidanylidene-propan-2-yl]phosphonamidic acid | Authors: | Maize, K.M, Finzel, B.C. | Deposit date: | 2017-06-26 | Release date: | 2017-10-18 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | A Crystal Structure Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides. Mol. Pharm., 14, 2017
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4PKR
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![BU of 4pkr by Molmil](/molmil-images/mine/4pkr) | Anthrax toxin lethal factor with bound small molecule inhibitor 10 | Descriptor: | CHLORIDE ION, GLYCEROL, Lethal factor, ... | Authors: | Maize, K.M, De la Mora, T, Finzel, B.C. | Deposit date: | 2014-05-15 | Release date: | 2014-11-12 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding. Acta Crystallogr.,Sect.D, 70, 2014
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4PKU
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![BU of 4pku by Molmil](/molmil-images/mine/4pku) | Anthrax toxin lethal factor with bound small molecule inhibitor 15 | Descriptor: | Lethal factor, N~2~-(3-aminobenzyl)-N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide, ZINC ION | Authors: | Maize, K.M, De la Mora, T, Finzel, B.C. | Deposit date: | 2014-05-15 | Release date: | 2014-11-12 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding. Acta Crystallogr.,Sect.D, 70, 2014
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4PKW
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![BU of 4pkw by Molmil](/molmil-images/mine/4pkw) | Anthrax toxin lethal factor with bound small molecule inhibitor GM6001 | Descriptor: | 1,2-ETHANEDIOL, 3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE, GLYCEROL, ... | Authors: | Maize, K.M, De la Mora, T, Finzel, B.C. | Deposit date: | 2014-05-15 | Release date: | 2014-11-12 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding. Acta Crystallogr.,Sect.D, 70, 2014
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4PKQ
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![BU of 4pkq by Molmil](/molmil-images/mine/4pkq) | Anthrax toxin lethal factor with bound zinc | Descriptor: | 1,2-ETHANEDIOL, Lethal factor, TRIETHYLENE GLYCOL, ... | Authors: | Maize, K.M, Finzel, B.C. | Deposit date: | 2014-05-15 | Release date: | 2014-11-12 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding. Acta Crystallogr.,Sect.D, 70, 2014
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4PKV
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![BU of 4pkv by Molmil](/molmil-images/mine/4pkv) | Anthrax toxin lethal factor with bound small molecule inhibitor 16 | Descriptor: | Lethal factor, N~2~-[4-(aminomethyl)benzyl]-N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide, ZINC ION | Authors: | Maize, K.M, Finzel, B.C. | Deposit date: | 2014-05-15 | Release date: | 2014-11-12 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding. Acta Crystallogr.,Sect.D, 70, 2014
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4PKT
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![BU of 4pkt by Molmil](/molmil-images/mine/4pkt) | Anthrax toxin lethal factor with bound small molecule inhibitor 13 | Descriptor: | Lethal factor, N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-N~2~-(4-nitrobenzyl)-D-alaninamide, ZINC ION | Authors: | Maize, K.M, De la Mora, T, Finzel, B.C. | Deposit date: | 2014-05-15 | Release date: | 2014-11-12 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding. Acta Crystallogr.,Sect.D, 70, 2014
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4PKS
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![BU of 4pks by Molmil](/molmil-images/mine/4pks) | Anthrax toxin lethal factor with bound small molecule inhibitor 11 | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, Lethal factor, ... | Authors: | Maize, K.M, De la Mora, T, Finzel, B.C. | Deposit date: | 2014-05-15 | Release date: | 2014-11-12 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding. Acta Crystallogr.,Sect.D, 70, 2014
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4XM8
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![BU of 4xm8 by Molmil](/molmil-images/mine/4xm8) | Anthrax toxin lethal factor with ligand-induced binding pocket | Descriptor: | Lethal factor, N-hydroxy-N~2~-{[3-(methoxymethyl)phenyl]sulfonyl}-N~2~-(2-methylpropyl)-D-valinamide, ZINC ION | Authors: | Maize, K.M, Finzel, B.C. | Deposit date: | 2015-01-14 | Release date: | 2015-11-11 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Ligand-induced expansion of the S1' site in the anthrax toxin lethal factor. Febs Lett., 589, 2015
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4XM6
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![BU of 4xm6 by Molmil](/molmil-images/mine/4xm6) | Anthrax toxin lethal factor with ligand-induced binding pocket | Descriptor: | 1,2-ETHANEDIOL, Lethal factor, N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-N~2~-(2-methylpropyl)-D-valinamide, ... | Authors: | Maize, K.M, De la Mora-Rey, T, Finzel, B.C. | Deposit date: | 2015-01-14 | Release date: | 2015-11-11 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.352 Å) | Cite: | Ligand-induced expansion of the S1' site in the anthrax toxin lethal factor. Febs Lett., 589, 2015
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4XM7
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![BU of 4xm7 by Molmil](/molmil-images/mine/4xm7) | Anthrax toxin lethal factor with ligand-induced binding pocket | Descriptor: | 1,2-ETHANEDIOL, Lethal factor, N~2~-[(4-fluoro-3-methoxyphenyl)sulfonyl]-N-hydroxy-N~2~-(2-methylpropyl)-D-valinamide, ... | Authors: | Maize, K.M, Finzel, B.C. | Deposit date: | 2015-01-14 | Release date: | 2015-11-11 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Ligand-induced expansion of the S1' site in the anthrax toxin lethal factor. Febs Lett., 589, 2015
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4INI
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![BU of 4ini by Molmil](/molmil-images/mine/4ini) | Human Histidine Triad Nucleotide Binding Protein 2 with Bound AMP | Descriptor: | 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE, ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, ... | Authors: | Maize, K.M, Wagner, C.R, Finzel, B.C. | Deposit date: | 2013-01-04 | Release date: | 2013-05-22 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structural characterization of human histidine triad nucleotide-binding protein 2, a member of the histidine triad superfamily. Febs J., 280, 2013
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4INC
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![BU of 4inc by Molmil](/molmil-images/mine/4inc) | Human Histidine Triad Nucleotide Binding Protein 2 | Descriptor: | CHLORIDE ION, Histidine triad nucleotide-binding protein 2, mitochondrial | Authors: | Maize, K.M, Wagner, C.R, Finzel, B.C. | Deposit date: | 2013-01-04 | Release date: | 2013-05-22 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.19 Å) | Cite: | Structural characterization of human histidine triad nucleotide-binding protein 2, a member of the histidine triad superfamily. Febs J., 280, 2013
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6B42
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![BU of 6b42 by Molmil](/molmil-images/mine/6b42) | |
5KM4
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![BU of 5km4 by Molmil](/molmil-images/mine/5km4) | |
5KLZ
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![BU of 5klz by Molmil](/molmil-images/mine/5klz) | |
5KM5
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![BU of 5km5 by Molmil](/molmil-images/mine/5km5) | Human Histidine Triad Nucleotide Binding Protein 2 (hHint2) triciribine 5'-monoposphate catalytic product complex | Descriptor: | 5-methyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-1,5-dihydro-1,4,5,6,8-pentaazaacenaphthylen-3-amine, CHLORIDE ION, Histidine triad nucleotide-binding protein 2, ... | Authors: | Maize, K.M, Finzel, B.C. | Deposit date: | 2016-06-26 | Release date: | 2017-06-28 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A Crystal Structure Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides. Mol. Pharm., 14, 2017
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5KM9
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![BU of 5km9 by Molmil](/molmil-images/mine/5km9) | |
5KM3
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![BU of 5km3 by Molmil](/molmil-images/mine/5km3) | |
5KM1
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![BU of 5km1 by Molmil](/molmil-images/mine/5km1) | |
5KMA
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![BU of 5kma by Molmil](/molmil-images/mine/5kma) | Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) H112N mutant nucleoside D-Trp phosphoramidate substrate complex | Descriptor: | CHLORIDE ION, Histidine triad nucleotide-binding protein 1, [(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-3~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-~{N}-ethyl-phosphonamidic acid | Authors: | Maize, K.M, Finzel, B.C. | Deposit date: | 2016-06-26 | Release date: | 2017-06-28 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | A Crystal Structure Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides. Mol. Pharm., 14, 2017
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5KMB
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![BU of 5kmb by Molmil](/molmil-images/mine/5kmb) | Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) H112N mutant nucleoside L-Trp phosphoramidate substrate complex | Descriptor: | CHLORIDE ION, Histidine triad nucleotide-binding protein 1, [(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-~{N}-[(2~ {S})-3-(1~{H}-indol-3-yl)-1-(methylamino)-1-oxidanylidene-propan-2-yl]phosphonamidic acid | Authors: | Maize, K.M, Finzel, B.C. | Deposit date: | 2016-06-26 | Release date: | 2017-06-28 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | A Crystal Structure Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides. Mol. Pharm., 14, 2017
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5KM6
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![BU of 5km6 by Molmil](/molmil-images/mine/5km6) | Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) H112N mutant Ara-A nucleoside phosphoramidate substrate complex | Descriptor: | Histidine triad nucleotide-binding protein 1, [(2~{R},3~{S},4~{S},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-~{N}-[2-(1~{H}-indol-3-yl)ethyl]phosphonamidic acid | Authors: | Maize, K.M, Finzel, B.C. | Deposit date: | 2016-06-26 | Release date: | 2017-06-28 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | A Crystal Structure Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides. Mol. Pharm., 14, 2017
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5KM2
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![BU of 5km2 by Molmil](/molmil-images/mine/5km2) | |