5KM6

Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) H112N mutant Ara-A nucleoside phosphoramidate substrate complex

Summary for 5KM6

• Entry DOI: 10.2210/pdb5km6/pdb
• Related: 3TW2 5IPB 5IPC 5IPD 5IPE 5KLY 5KLZ 5KM0 5KM1 5KM2 5KM3 5KM4 5KM5 5KM7 5KM8 5KM9 5KMA 5KMB 5KMC
• Descriptor: Histidine triad nucleotide-binding protein 1, [(2~{R},3~{S},4~{S},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-~{N}-[2-(1~{H}-indol-3-yl)ethyl]phosphonamidic acid (3 entities in total)
• Functional Keywords: hint, histidine triad, hit, hydrolase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: P49773
• Total number of polymer chains: 1
• Total formula weight: 14561.57

Authors

Maize, K.M.,Finzel, B.C. (deposition date: 2016-06-26, release date: 2017-06-28, Last modification date: 2023-09-27)

• Primary citation: Maize, K.M.,Shah, R.,Strom, A.,Kumarapperuma, S.,Zhou, A.,Wagner, C.R.,Finzel, B.C.; A Crystal Structure Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides.; Mol. Pharm., 14:3987-3997, 2017; PubMed: 28968488; DOI: 10.1021/acs.molpharmaceut.7b00664

Experimental method

X-RAY DIFFRACTION (1.6 Å)