5IPC
Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) H112N mutant nucleoside thiophosphoramidate substrate complex
Summary for 5IPC
Entry DOI | 10.2210/pdb5ipc/pdb |
Related | 1KPA 3TW2 4EQE 4EQG 4EQH 5I2E 5I2F 5IPB 5IPD 5IPE |
Descriptor | Histidine triad nucleotide-binding protein 1, 5'-S-[(S)-hydroxy{[2-(1H-indol-3-yl)ethyl]amino}phosphoryl]-5'-thioguanosine, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | hint, histidine triad, hit, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P49773 |
Total number of polymer chains | 2 |
Total formula weight | 28887.43 |
Authors | Maize, K.M.,Finzel, B.C. (deposition date: 2016-03-09, release date: 2017-03-15, Last modification date: 2023-09-27) |
Primary citation | Shah, R.,Maize, K.M.,Zhou, X.,Finzel, B.C.,Wagner, C.R. Caught before Released: Structural Mapping of the Reaction Trajectory for the Sofosbuvir Activating Enzyme, Human Histidine Triad Nucleotide Binding Protein 1 (hHint1). Biochemistry, 56:3559-3570, 2017 Cited by PubMed: 28691797DOI: 10.1021/acs.biochem.7b00148 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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