5IPC

Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) H112N mutant nucleoside thiophosphoramidate substrate complex

Summary for 5IPC

• Entry DOI: 10.2210/pdb5ipc/pdb
• Related: 1KPA 3TW2 4EQE 4EQG 4EQH 5I2E 5I2F 5IPB 5IPD 5IPE
• Descriptor: Histidine triad nucleotide-binding protein 1, 5'-S-[(S)-hydroxy{[2-(1H-indol-3-yl)ethyl]amino}phosphoryl]-5'-thioguanosine, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: hint, histidine triad, hit, hydrolase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: P49773
• Total number of polymer chains: 2
• Total formula weight: 28887.43

Authors

Maize, K.M.,Finzel, B.C. (deposition date: 2016-03-09, release date: 2017-03-15, Last modification date: 2023-09-27)

• Primary citation: Shah, R.,Maize, K.M.,Zhou, X.,Finzel, B.C.,Wagner, C.R.; Caught before Released: Structural Mapping of the Reaction Trajectory for the Sofosbuvir Activating Enzyme, Human Histidine Triad Nucleotide Binding Protein 1 (hHint1).; Biochemistry, 56:3559-3570, 2017; PubMed: 28691797; DOI: 10.1021/acs.biochem.7b00148

Experimental method

X-RAY DIFFRACTION (1.3 Å)