5IPC
Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) H112N mutant nucleoside thiophosphoramidate substrate complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Histidine triad nucleotide-binding protein 1 | polymer | 129 | 14072.1 | 2 | UniProt (P49773) Pfam (PF01230) | Homo sapiens (Human) | Adenosine 5'-monophosphoramidase |
| 2 | C (A) | 5'-S-[(S)-hydroxy{[2-(1H-indol-3-yl)ethyl]amino}phosphoryl]-5'-thioguanosine | non-polymer | 521.5 | 1 | Chemie (6CE) | |||
| 3 | D, E, G (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 4 | F (B) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | H, I (A, B) | water | water | 18.0 | 228 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 126 (UniProt: P49773)
| PDB | External Database | Details |
|---|---|---|
| Ser -2 | - | expression tag |
| Asn -1 | - | expression tag |
| Ala 0 | - | expression tag |
| Asn 112 | His 112 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28144.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 743.1 | |
| All* | Total formula weight | 28887.4 |
