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4MAT
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BU of 4mat by Molmil
E.COLI METHIONINE AMINOPEPTIDASE HIS79ALA MUTANT
分子名称: PROTEIN (METHIONINE AMINOPEPTIDASE), SODIUM ION
著者Lowther, W.T, Orville, A.M, Madden, D.T, Lim, S, Rich, D.H, Matthews, B.W.
登録日1999-03-29
公開日1999-06-18
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Escherichia coli methionine aminopeptidase: implications of crystallographic analyses of the native, mutant, and inhibited enzymes for the mechanism of catalysis.
Biochemistry, 38, 1999
1L1D
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Crystal structure of the C-terminal methionine sulfoxide reductase domain (MsrB) of N. gonorrhoeae pilB
分子名称: CACODYLATE ION, peptide methionine sulfoxide reductase
著者Lowther, W.T, Weissbach, H, Etienne, F, Brot, N, Matthews, B.W.
登録日2002-02-15
公開日2002-05-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献The mirrored methionine sulfoxide reductases of Neisseria gonorrhoeae pilB.
Nat.Struct.Biol., 9, 2002
2MAT
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E.COLI METHIONINE AMINOPEPTIDASE AT 1.9 ANGSTROM RESOLUTION
分子名称: COBALT (II) ION, PROTEIN (METHIONINE AMINOPEPTIDASE), SODIUM ION
著者Lowther, W.T, Orville, A.M, Madden, D.T, Lim, S, Rich, D.H, Matthews, B.W.
登録日1999-03-29
公開日1999-06-18
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Escherichia coli methionine aminopeptidase: implications of crystallographic analyses of the native, mutant, and inhibited enzymes for the mechanism of catalysis.
Biochemistry, 38, 1999
3MAT
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E.COLI METHIONINE AMINOPEPTIDASE TRANSITION-STATE INHIBITOR COMPLEX
分子名称: COBALT (II) ION, METHIONINE AMINOPEPTIDASE, SODIUM ION, ...
著者Lowther, W.T, Orville, A.M, Madden, D.T, Lim, S, Rich, D.H, Matthews, B.W.
登録日1999-03-29
公開日1999-06-18
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Escherichia coli methionine aminopeptidase: implications of crystallographic analyses of the native, mutant, and inhibited enzymes for the mechanism of catalysis.
Biochemistry, 38, 1999
1FVG
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BU of 1fvg by Molmil
CRYSTAL STRUCTURE OF BOVINE PEPTIDE METHIONINE SULFOXIDE REDUCTASE
分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, PEPTIDE METHIONINE SULFOXIDE REDUCTASE
著者Lowther, W.T, Brot, N, Weissbach, H, Matthews, B.W.
登録日2000-09-19
公開日2000-11-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structure and mechanism of peptide methionine sulfoxide reductase, an "anti-oxidation" enzyme.
Biochemistry, 39, 2000
1FVA
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CRYSTAL STRUCTURE OF BOVINE METHIONINE SULFOXIDE REDUCTASE
分子名称: PEPTIDE METHIONINE SULFOXIDE REDUCTASE
著者Lowther, W.T, Brot, N, Weissbach, H, Matthews, B.W.
登録日2000-09-19
公開日2000-11-08
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structure and mechanism of peptide methionine sulfoxide reductase, an "anti-oxidation" enzyme.
Biochemistry, 39, 2000
8FW6
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Human Lactate Dehydrogenase A in Complex with Inhibitor CHK-336
分子名称: (2P)-2-{5-(cyclopropylmethyl)-3-(4-fluorophenyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-1H-pyrazol-1-yl}-1,3-thiazole-4-carboxylic acid, 1,2-ETHANEDIOL, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ...
著者Lowther, W.T, Gumpena, R.
登録日2023-01-20
公開日2024-01-24
実験手法X-RAY DIFFRACTION (2.34 Å)
主引用文献Human Lactate Dehydrogenase A in complex with inhibitor CHK-336
To Be Published
1C24
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E. COLI METHIONINE AMINOPEPTIDASE: METHIONINE PHOSPHINATE COMPLEX
分子名称: (1-AMINO-3-METHYLSULFANYL-PROPYL)-PHOSPHINIC ACID, COBALT (II) ION, METHIONINE AMINOPEPTIDASE, ...
著者Lowther, W.T, Zhang, Y, Sampson, P.B, Honek, J.F, Matthews, B.W.
登録日1999-07-22
公開日1999-11-17
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Insights into the mechanism of Escherichia coli methionine aminopeptidase from the structural analysis of reaction products and phosphorus-based transition-state analogues.
Biochemistry, 38, 1999
1C21
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E. COLI METHIONINE AMINOPEPTIDASE: METHIONINE COMPLEX
分子名称: COBALT (II) ION, METHIONINE, METHIONINE AMINOPEPTIDASE, ...
著者Lowther, W.T, Zhang, Y, Sampson, P.B, Honek, J.F, Matthews, B.W.
登録日1999-07-22
公開日1999-11-17
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Insights into the mechanism of Escherichia coli methionine aminopeptidase from the structural analysis of reaction products and phosphorus-based transition-state analogues.
Biochemistry, 38, 1999
1C23
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E. COLI METHIONINE AMINOPEPTIDASE: METHIONINE PHOSPHONATE COMPLEX
分子名称: (1-AMINO-3-METHYLSULFANYL-PROPYL)-PHOSPHONIC ACID, COBALT (II) ION, METHIONINE AMINOPEPTIDASE, ...
著者Lowther, W.T, Zhang, Y, Sampson, P.B, Honek, J.F, Matthews, B.W.
登録日1999-07-22
公開日1999-11-17
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Insights into the mechanism of Escherichia coli methionine aminopeptidase from the structural analysis of reaction products and phosphorus-based transition-state analogues.
Biochemistry, 38, 1999
1C22
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E. COLI METHIONINE AMINOPEPTIDASE: TRIFLUOROMETHIONINE COMPLEX
分子名称: 2-AMINO-4-TRIFLUOROMETHYLSULFANYL-BUTYRIC ACID, COBALT (II) ION, METHIONINE AMINOPEPTIDASE, ...
著者Lowther, W.T, Zhang, Y, Sampson, P.B, Honek, J.F, Matthews, B.W.
登録日1999-07-22
公開日1999-11-17
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Insights into the mechanism of Escherichia coli methionine aminopeptidase from the structural analysis of reaction products and phosphorus-based transition-state analogues.
Biochemistry, 38, 1999
1C27
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E. COLI METHIONINE AMINOPEPTIDASE:NORLEUCINE PHOSPHONATE COMPLEX
分子名称: (1-AMINO-PENTYL)-PHOSPHONIC ACID, COBALT (II) ION, METHIONINE AMINOPEPTIDASE, ...
著者Lowther, W.T, Zhang, Y, Sampson, P.B, Honek, J.F, Matthews, B.W.
登録日1999-07-22
公開日1999-11-17
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Insights into the mechanism of Escherichia coli methionine aminopeptidase from the structural analysis of reaction products and phosphorus-based transition-state analogues.
Biochemistry, 38, 1999
6WSK
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BU of 6wsk by Molmil
Crystal Structure of the Cannabinoid Receptor 1 Interacting Protein 1a (CRIP1a)
分子名称: Endolysin,CB1 cannabinoid receptor-interacting protein 1 fusion
著者Booth, W.T, Howlett, A.C, Lowther, W.T.
登録日2020-05-01
公開日2021-09-08
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Cannabinoid receptor interacting protein 1a interacts with myristoylated G alpha i N terminus via a unique gapped beta-barrel structure.
J.Biol.Chem., 297, 2021
3S5N
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Crystal Structure of Human 4-hydroxy-2-oxoglutarate Aldolase
分子名称: 1,2-ETHANEDIOL, 4-hydroxy-2-oxoglutarate aldolase, mitochondrial, ...
著者Riedel, T.J, Lowther, W.T.
登録日2011-05-23
公開日2011-10-26
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural and Biochemical Studies of Human 4-hydroxy-2-oxoglutarate Aldolase: Implications for Hydroxyproline Metabolism in Primary Hyperoxaluria.
Plos One, 6, 2011
3S5O
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Crystal Structure of Human 4-hydroxy-2-oxoglutarate Aldolase Bound to Pyruvate
分子名称: 1,2-ETHANEDIOL, 4-hydroxy-2-oxoglutarate aldolase, mitochondrial, ...
著者Riedel, T.J, Lowther, W.T.
登録日2011-05-23
公開日2011-10-26
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Structural and Biochemical Studies of Human 4-hydroxy-2-oxoglutarate Aldolase: Implications for Hydroxyproline Metabolism in Primary Hyperoxaluria.
Plos One, 6, 2011
2H30
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Crystal structure of the N-terminal domain of PilB from Neisseria gonorrhoeae
分子名称: Peptide methionine sulfoxide reductase msrA/msrB
著者Brot, N, Collet, J.F, Johnson, L.C, Jonsson, T.J, Weissbach, H, Lowther, W.T.
登録日2006-05-20
公開日2006-08-22
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献The Thioredoxin Domain of Neisseria gonorrhoeae PilB Can Use Electrons from DsbD to Reduce Downstream Methionine Sulfoxide Reductases.
J.Biol.Chem., 281, 2006
4XJV
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BU of 4xjv by Molmil
Crystal structure of human thioesterase 2
分子名称: CHLORIDE ION, S-acyl fatty acid synthase thioesterase, medium chain
著者Ritchie, M.K, Kridel, S.J, Lowther, W.T.
登録日2015-01-09
公開日2015-12-16
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structure and Substrate Specificity of Human Thioesterase 2: INSIGHTS INTO THE MOLECULAR BASIS FOR THE MODULATION OF FATTY ACID SYNTHASE.
J.Biol.Chem., 291, 2016
5IJT
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Human Peroxiredoxin 2 Oxidized (SS)
分子名称: Peroxiredoxin-2, ZINC ION
著者Haynes, A.C, Bolduc, J.A, Lowther, W.T.
登録日2016-03-02
公開日2017-09-06
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.148 Å)
主引用文献Novel hyperoxidation resistance motifs in 2-Cys peroxiredoxins.
J. Biol. Chem., 293, 2018
7LJ1
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Human Prx1-Srx Decameric Complex
分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, DI(HYDROXYETHYL)ETHER, ...
著者Forshaw, T.E, Reisz, J.A, Nelson, K.J, Gumpena, R, Lawson, J.R, Jonsson, T, Wu, H, Clodfelter, J.E, Johnson, L, Furdui, C.M, Lowther, W.T.
登録日2021-01-28
公開日2021-07-14
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.97 Å)
主引用文献Specificity of Human Sulfiredoxin for Reductant and Peroxiredoxin Oligomeric State.
Antioxidants (Basel), 10, 2021
7M2N
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Crystal structure of Human Lactate Dehydrogenase A with Inhibitor Compound 15
分子名称: 1,2-ETHANEDIOL, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 5-[(5'-{1-(4-carboxy-1,3-thiazol-2-yl)-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-1H-pyrazol-3-yl}-2'-fluoro[1,1'-biphenyl]-4-yl)oxy]-1H-1,2,3-triazole-4-carboxylic acid, ...
著者Gumpena, R, Ding, J, Powell, D.A, Lowther, W.T.
登録日2021-03-17
公開日2021-07-14
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Dual Glycolate Oxidase/Lactate Dehydrogenase A Inhibitors for Primary Hyperoxaluria
ACS Medicinal Chemistry Letters, 12, 2021
7M2O
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Crystal structure of Human Glycolate Oxidase with Inhibitor Compound 15
分子名称: 1,2-ETHANEDIOL, 5-[(5'-{1-(4-carboxy-1,3-thiazol-2-yl)-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-1H-pyrazol-3-yl}-2'-fluoro[1,1'-biphenyl]-4-yl)oxy]-1H-1,2,3-triazole-4-carboxylic acid, DI(HYDROXYETHYL)ETHER, ...
著者Gumpena, R, Ding, J, Powell, D.A, Lowther, W.T.
登録日2021-03-17
公開日2021-07-14
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献Dual Glycolate Oxidase/Lactate Dehydrogenase A Inhibitors for Primary Hyperoxaluria
ACS Medicinal Chemistry Letters, 12, 2021
1XW4
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Crystal Structure of Human Sulfiredoxin (Srx) in Complex with ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, Sulfiredoxin
著者Murray, M.S, Jonsson, T.J, Johnson, L.C, Poole, L.B, Lowther, W.T.
登録日2004-10-29
公開日2005-05-24
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis for the retroreduction of inactivated peroxiredoxins by human sulfiredoxin.
Biochemistry, 44, 2005
1XW3
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Crystal Structure of Human Sulfiredoxin (Srx)
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, PHOSPHATE ION, SULFIREDOXIN
著者Murray, M.S, Jonsson, T.J, Johnson, L.C, Poole, L.B, Lowther, W.T.
登録日2004-10-29
公開日2005-05-24
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structural basis for the retroreduction of inactivated peroxiredoxins by human sulfiredoxin.
Biochemistry, 44, 2005
3CYI
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Crystal Structure of Human Sulfiredoxin (Srx) in Complex with ATP:Mg2+
分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Sulfiredoxin-1
著者Jonsson, T.J, Murray, M.S, Johnson, L.C, Lowther, W.T.
登録日2008-04-25
公開日2008-07-01
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Reduction of Cysteine Sulfinic Acid in Peroxiredoxin by Sulfiredoxin Proceeds Directly through a Sulfinic Phosphoryl Ester Intermediate.
J.Biol.Chem., 283, 2008
3HY2
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Crystal Structure of Sulfiredoxin in Complex with Peroxiredoxin I and ATP:Mg2+
分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Peroxiredoxin-1, ...
著者Jonsson, T.J, Johnson, L.C, Lowther, W.T.
登録日2009-06-22
公開日2009-10-06
最終更新日2021-10-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Protein Engineering of the Quaternary Sulfiredoxin-Peroxiredoxin Enzyme-Substrate Complex Reveals the Molecular Basis for Cysteine Sulfinic Acid Phosphorylation
J.Biol.Chem., 284, 2009

 

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