8IWE
| Cryo-EM structure of the SPE-mTAAR9 complex | Descriptor: | SPERMIDINE, Trace amine-associated receptor 9 | Authors: | Sun, J.P, Li, Q, Yang, F, Xu, Y.F, Guo, L.L, Lian, S, Zhang, M.H, Rong, N.K. | Deposit date: | 2023-03-29 | Release date: | 2023-05-31 | Last modified: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis of amine odorant perception by a mammal olfactory receptor. Nature, 618, 2023
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3HYF
| Crystal structure of HIV-1 RNase H p15 with engineered E. coli loop and active site inhibitor | Descriptor: | 2-(3,4-dichlorobenzyl)-5,6-dihydroxypyrimidine-4-carboxylic acid, ACETATE ION, GLYCEROL, ... | Authors: | Lansdon, E.B, Kirschberg, T.A. | Deposit date: | 2009-06-22 | Release date: | 2009-10-20 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information. J.Med.Chem., 52, 2009
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3IPY
| X-Ray structure of Human Deoxycytidine Kinase in complex with an inhibitor | Descriptor: | 4-(1-benzothiophen-2-yl)-6-[4-(2-oxo-2-pyrrolidin-1-ylethyl)piperazin-1-yl]pyrimidine, D-MALATE, Deoxycytidine kinase | Authors: | Tari, L.W, Swanson, R.V, Hunter, M, Hoffman, I, Stouch, T.R, Carson, K.G. | Deposit date: | 2009-08-18 | Release date: | 2010-08-18 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.54 Å) | Cite: | Lead optimization and structure-based design of potent and bioavailable deoxycytidine kinase inhibitors. Bioorg.Med.Chem.Lett., 19, 2009
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3IPX
| X-Ray structure of Human Deoxycytidine Kinase in complex with ADP and an inhibitor | Descriptor: | 2'-deoxy-5-fluorocytidine, ADENOSINE-5'-DIPHOSPHATE, Deoxycytidine kinase, ... | Authors: | Tari, L.W, Swanson, R.V, Hunter, M, Hoffman, I, Stouch, T.R, Carson, K.G. | Deposit date: | 2009-08-18 | Release date: | 2010-08-18 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Lead optimization and structure-based design of potent and bioavailable deoxycytidine kinase inhibitors. Bioorg.Med.Chem.Lett., 19, 2009
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4GG5
| Crystal structure of CMET in complex with novel inhibitor | Descriptor: | 3-(4-methylpiperazin-1-yl)-N-(3-nitrobenzyl)-7-(trifluoromethyl)quinolin-5-amine, Hepatocyte growth factor receptor | Authors: | Liu, Q.F, Chen, T.T, Xu, Y.C. | Deposit date: | 2012-08-05 | Release date: | 2012-10-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.423 Å) | Cite: | Multisubstituted quinoxalines and pyrido[2,3-d]pyrimidines: Synthesis and SAR study as tyrosine kinase c-Met inhibitors. Bioorg.Med.Chem.Lett., 22, 2012
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4GG7
| Crystal structure of cMET in complex with novel inhibitor | Descriptor: | Hepatocyte growth factor receptor, N-(3-nitrobenzyl)-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-2-(trifluoromethyl)pyrido[2,3-d]pyrimidin-4-amine | Authors: | Liu, Q.F, Chen, T.T, Xu, Y.C. | Deposit date: | 2012-08-06 | Release date: | 2012-10-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Multisubstituted quinoxalines and pyrido[2,3-d]pyrimidines: Synthesis and SAR study as tyrosine kinase c-Met inhibitors. Bioorg.Med.Chem.Lett., 22, 2012
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2HDZ
| Crystal Structure Analysis of the UBF HMG box5 | Descriptor: | Nucleolar transcription factor 1 | Authors: | Rong, H, Teng, M.K, Niu, L.W. | Deposit date: | 2006-06-21 | Release date: | 2007-06-26 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of human upstream binding factor HMG box 5 and site for binding of the cell-cycle regulatory factor TAF1 Acta Crystallogr.,Sect.D, 63, 2007
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5GTY
| Crystal structure of EGFR 696-1022 T790M in complex with LXX-6-26 | Descriptor: | 1,2-ETHANEDIOL, 1-[(3R)-3-[4-azanyl-3-[3-chloranyl-4-[(6-methylpyridin-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one, Epidermal growth factor receptor | Authors: | Yan, X.E, Yun, C.H. | Deposit date: | 2016-08-23 | Release date: | 2017-09-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.14 Å) | Cite: | Discovery and characterization of a novel irreversible EGFR mutants selective and potent kinase inhibitor CHMFL-EGFR-26 with a distinct binding mode. Oncotarget, 8, 2017
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2MAW
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5IFG
| Crystal structure of HigA-HigB complex from E. Coli | Descriptor: | Antitoxin HigA, mRNA interferase HigB | Authors: | Yang, J.S, Zhou, K, Gao, z.Q, Liu, Q.S, Dong, Y.H. | Deposit date: | 2016-02-26 | Release date: | 2017-03-01 | Method: | X-RAY DIFFRACTION (2.702 Å) | Cite: | Structural insight into the E. coli HigBA complex Biochem. Biophys. Res. Commun., 478, 2016
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3PJA
| Crystal structure of human C3PO complex | Descriptor: | Translin, Translin-associated protein X | Authors: | Huang, N, Zhang, H. | Deposit date: | 2010-11-09 | Release date: | 2011-05-11 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure of C3PO and mechanism of human RISC activation. Nat.Struct.Mol.Biol., 18, 2011
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3QIP
| Structure of HIV-1 reverse transcriptase in complex with an RNase H inhibitor and nevirapine | Descriptor: | 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, 5,6-dihydroxy-2-[(2-phenyl-1H-indol-3-yl)methyl]pyrimidine-4-carboxylic acid, CHLORIDE ION, ... | Authors: | Lansdon, E.B, Kirschberg, T.A. | Deposit date: | 2011-01-27 | Release date: | 2011-04-20 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.0926 Å) | Cite: | Structural and Binding Analysis of Pyrimidinol Carboxylic Acid and N-Hydroxy Quinazolinedione HIV-1 RNase H Inhibitors. Antimicrob.Agents Chemother., 55, 2011
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3QIN
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2L5P
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7S2R
| nanobody bound to IL-2Rg | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit gamma, ... | Authors: | Glassman, C.R, Jude, K.M, Yen, M, Garcia, K.C. | Deposit date: | 2021-09-03 | Release date: | 2022-03-30 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Facile discovery of surrogate cytokine agonists. Cell, 185, 2022
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7S2S
| nanobody bound to Interleukin-2Rbeta | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, IL2Rb-binding nanobody, Interleukin-2 receptor subunit beta, ... | Authors: | Glassman, C.R, Jude, K.M, Yen, M, Garcia, K.C. | Deposit date: | 2021-09-03 | Release date: | 2022-03-30 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Facile discovery of surrogate cytokine agonists. Cell, 185, 2022
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7KO2
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8E9F
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7KRU
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7KRT
| Restraining state of a truncated Hsp70 DnaK | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Chaperone protein DnaK, MAGNESIUM ION | Authors: | Wang, W, Hendrickson, W.A. | Deposit date: | 2020-11-20 | Release date: | 2021-09-15 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.79 Å) | Cite: | Conformational equilibria in allosteric control of Hsp70 chaperones. Mol.Cell, 81, 2021
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7KRV
| Stimulating state of disulfide-bridged Hsp70 DnaK | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Chaperone protein DnaK fused with substrate peptide, MAGNESIUM ION, ... | Authors: | Wang, W, Hendrickson, W.A. | Deposit date: | 2020-11-20 | Release date: | 2021-09-15 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Conformational equilibria in allosteric control of Hsp70 chaperones. Mol.Cell, 81, 2021
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7KRW
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5HXW
| L-amino acid deaminase from Proteus vulgaris | Descriptor: | CETYL-TRIMETHYL-AMMONIUM, FLAVIN-ADENINE DINUCLEOTIDE, L-amino acid deaminase | Authors: | Zhou, H, Ju, Y, Niu, L, Teng, M. | Deposit date: | 2016-01-31 | Release date: | 2016-08-03 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.63 Å) | Cite: | Crystal structure of a membrane-bound l-amino acid deaminase from Proteus vulgaris J.Struct.Biol., 195, 2016
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6OE8
| The crystal structure of hyper-thermostable AgUricase mutant K12C/E286C | Descriptor: | MALONATE ION, TETRAETHYLENE GLYCOL, TRIETHYLENE GLYCOL, ... | Authors: | Shi, Y, Wang, T, Zhou, X.E, Liu, Q, Jiang, Y, Xu, H.E. | Deposit date: | 2019-03-27 | Release date: | 2019-08-21 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Structure-based design of a hyperthermostable AgUricase for hyperuricemia and gout therapy. Acta Pharmacol.Sin., 40, 2019
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5I39
| High resolution structure of L-amino acid deaminase from Proteus vulgaris with the deletion of the specific insertion sequence | Descriptor: | 1,2-ETHANEDIOL, FLAVIN-ADENINE DINUCLEOTIDE, L-amino acid deaminase | Authors: | Zhou, H, Ju, Y, Niu, L, Teng, M. | Deposit date: | 2016-02-10 | Release date: | 2016-08-03 | Last modified: | 2016-08-24 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Crystal structure of a membrane-bound l-amino acid deaminase from Proteus vulgaris J.Struct.Biol., 195, 2016
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