3O62
 
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3U52
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4GAM
 | | Complex structure of Methane monooxygenase hydroxylase and regulatory subunit | | Descriptor: | FE (III) ION, Methane monooxygenase component A alpha chain, Methane monooxygenase component A beta chain, ... | | Authors: | Lee, S.J, Lippard, S.J, Cho, U.-S. | | Deposit date: | 2012-07-25 | | Release date: | 2013-02-06 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.902 Å) | | Cite: | Control of substrate access to the active site in methane monooxygenase.
Nature, 494, 2013
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1MTY
 | | METHANE MONOOXYGENASE HYDROXYLASE FROM METHYLOCOCCUS CAPSULATUS (BATH) | | Descriptor: | FE (III) ION, METHANE MONOOXYGENASE HYDROXYLASE | | Authors: | Rosenzweig, A.C, Nordlund, P, Lippard, S.J, Frederick, C.A. | | Deposit date: | 1996-07-10 | | Release date: | 1997-04-21 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystal structures of the methane monooxygenase hydroxylase from Methylococcus capsulatus (Bath): implications for substrate gating and component interactions.
Proteins, 29, 1997
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3CO3
 | | X-Ray Crystal Structure of a Monofunctional Platinum-DNA Adduct, cis-{Pt(NH3)2(pyridine)}2+ Bound to Deoxyguanosine in a Dodecamer Duplex | | Descriptor: | 5'-D(*DCP*DCP*DTP*DCP*DTP*DCP*DGP*DTP*DCP*DTP*DCP*DC)-3', 5'-D(*DGP*DGP*DAP*DGP*DAP*DCP*DGP*DAP*DGP*DAP*DGP*DG)-3', cis-diammine(pyridine)chloroplatinum(II) | | Authors: | Lovejoy, K.S, Todd, R.C, Zhang, S, McCormick, M.S, D'Aquino, J.A, Reardon, J.T, Sancar, A, Giacomini, K.M, Lippard, S.J. | | Deposit date: | 2008-03-27 | | Release date: | 2008-06-10 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.16 Å) | | Cite: | cis-Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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2RDB
 | | X-ray Crystal Structure of Toluene/o-Xylene Monooxygenase Hydroxylase I100W Mutant | | Descriptor: | 3[N-MORPHOLINO]PROPANE SULFONIC ACID, FE (III) ION, GLYCEROL, ... | | Authors: | Murray, L.J, Garcia-Serres, R, McCormick, M.S, Davydov, R, Naik, S, Hoffman, B.M, Huynh, B.H, Lippard, S.J. | | Deposit date: | 2007-09-21 | | Release date: | 2007-12-18 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Dioxygen activation at non-heme diiron centers: oxidation of a proximal residue in the I100W variant of toluene/o-xylene monooxygenase hydroxylase.
Biochemistry, 46, 2007
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1AIO
 | | CRYSTAL STRUCTURE OF A DOUBLE-STRANDED DNA CONTAINING THE MAJOR ADDUCT OF THE ANTICANCER DRUG CISPLATIN | | Descriptor: | Cisplatin, DNA (5'-D(*CP*CP*(BRU)P*CP*TP*[PT(NH3)2(GP*GP)]*TP*CP*TP*CP*C)-3'), DNA (5'-D(*GP*GP*AP*GP*AP*CP*CP*AP*GP*AP*GP*G)-3') | | Authors: | Takahara, P.M, Rosenzweig, A.C, Frederick, C.A, Lippard, S.J. | | Deposit date: | 1997-04-23 | | Release date: | 1997-04-24 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structure of double-stranded DNA containing the major adduct of the anticancer drug cisplatin.
Nature, 377, 1995
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1MMO
 | | CRYSTAL STRUCTURE OF A BACTERIAL NON-HAEM IRON HYDROXYLASE THAT CATALYSES THE BIOLOGICAL OXIDATION OF METHANE | | Descriptor: | ACETIC ACID, FE (III) ION, METHANE MONOOXYGENASE HYDROLASE (ALPHA CHAIN), ... | | Authors: | Rosenzweig, A.C, Frederick, C.A, Lippard, S.J, Nordlund, P. | | Deposit date: | 1994-02-22 | | Release date: | 1995-02-27 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of a bacterial non-haem iron hydroxylase that catalyses the biological oxidation of methane.
Nature, 366, 1993
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1LU5
 | | 2.4 Angstrom Crystal Structure of the Asymmetric Platinum Complex {Pt(ammine)(cyclohexylamine)}2+ Bound to a Dodecamer DNA Duplex | | Descriptor: | 5'-D(*CP*CP*TP*CP*TP*GP*GP*TP*CP*TP*CP*C)-3', 5'-D(*GP*GP*AP*GP*AP*CP*CP*AP*GP*AP*GP*G)-3', CIS-(AMMINE)(CYCLOHEXYLAMINE)PLATINUM(II) COMPLEX | | Authors: | Silverman, A.P, Bu, W, Cohen, S.M, Lippard, S.J. | | Deposit date: | 2002-05-21 | | Release date: | 2002-12-20 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | 2.4-A Crystal Structure of the Asymmetric Platinum Complex {Pt(ammine)(cyclohexylamine)}2+ Bound to
a Dodecamer DNA Duplex
J.Biol.Chem., 277, 2002
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1IHH
 | | 2.4 ANGSTROM CRYSTAL STRUCTURE OF AN OXALIPLATIN 1,2-D(GPG) INTRASTRAND CROSS-LINK IN A DNA DODECAMER DUPLEX | | Descriptor: | 1R,2R-DIAMINOCYCLOHEXANE, 5'-D(*CP*CP*TP*CP*TP*GP*GP*TP*CP*TP*CP*C)-3', 5'-D(*GP*GP*AP*GP*AP*CP*CP*AP*GP*AP*GP*G)-3', ... | | Authors: | Spingler, B, Whittington, D.A, Lippard, S.J. | | Deposit date: | 2001-04-19 | | Release date: | 2001-10-26 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | 2.4 A crystal structure of an oxaliplatin 1,2-d(GpG) intrastrand cross-link in a DNA dodecamer duplex.
Inorg.Chem., 40, 2001
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1JQ4
 | | [2Fe-2S] Domain of Methane Monooxygenase Reductase from Methylococcus capsulatus (Bath) | | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, METHANE MONOOXYGENASE COMPONENT C | | Authors: | Mueller, J, Lugovskoy, A.A, Wagner, G, Lippard, S.J. | | Deposit date: | 2001-08-03 | | Release date: | 2002-01-09 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | NMR structure of the [2Fe-2S] ferredoxin domain from soluble methane monooxygenase reductase and interaction with its hydroxylase.
Biochemistry, 41, 2002
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2INN
 | | Structure of the Phenol Hydroxyalse-Regulatory Protein Complex | | Descriptor: | FE (III) ION, MOLYBDATE ION, Phenol hydroxylase component phL, ... | | Authors: | Sazinsky, M.H, Dunten, P.W, McCormick, M.S, Lippard, S.J. | | Deposit date: | 2006-10-08 | | Release date: | 2007-01-16 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | X-ray Structure of a Hydroxylase-Regulatory Protein Complex from a Hydrocarbon-Oxidizing Multicomponent Monooxygenase, Pseudomonas sp. OX1 Phenol Hydroxylase.
Biochemistry, 45, 2006
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2IND
 | | Mn(II) Reconstituted Toluene/o-xylene Monooxygenase Hydroxylase X-ray Crystal Structure | | Descriptor: | HEXAETHYLENE GLYCOL, MANGANESE (II) ION, Toluene, ... | | Authors: | McCormick, M.S, Sazinsky, M.H, Condon, K.L, Lippard, S.J. | | Deposit date: | 2006-10-06 | | Release date: | 2006-12-05 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | X-ray crystal structures of manganese(II)-reconstituted and native toluene/o-xylene monooxygenase hydroxylase reveal rotamer shifts in conserved residues and an enhanced view of the protein interior.
J.Am.Chem.Soc., 128, 2006
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2INP
 | | Structure of the Phenol Hydroxylase-Regulatory Protein Complex | | Descriptor: | FE (III) ION, Phenol hydroxylase component phL, Phenol hydroxylase component phM, ... | | Authors: | Sazinsky, M.S, Dunten, P.W, McCormick, M.S, Lippard, S.J. | | Deposit date: | 2006-10-08 | | Release date: | 2007-01-16 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | X-ray Structure of a Hydroxylase-Regulatory Protein Complex from a Hydrocarbon-Oxidizing Multicomponent Monooxygenase, Pseudomonas sp. OX1 Phenol Hydroxylase.
Biochemistry, 45, 2006
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2INC
 | | Native Toluene/o-xylene Monooxygenase Hydroxylase X-ray Crystal Structure | | Descriptor: | FE (III) ION, HEXAETHYLENE GLYCOL, Toluene, ... | | Authors: | McCormick, M.S, Sazinsky, M.H, Condon, K.L, Lippard, S.J. | | Deposit date: | 2006-10-06 | | Release date: | 2006-11-28 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | X-ray crystal structures of manganese(II)-reconstituted and native toluene/o-xylene monooxygenase hydroxylase reveal rotamer shifts in conserved residues and an enhanced view of the protein interior.
J.Am.Chem.Soc., 128, 2006
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3LPV
 | | X-ray crystal structure of duplex DNA containing a cisplatin 1,2-d(GpG) intrastrand cross-link | | Descriptor: | 5'-D(*CP*CP*TP*CP*TP*GP*GP*TP*CP*TP*CP*C)-3', 5'-D(*GP*GP*AP*GP*AP*CP*CP*AP*GP*AP*GP*G)-3', Cisplatin, ... | | Authors: | Todd, R.C, Lippard, S.J. | | Deposit date: | 2010-02-06 | | Release date: | 2010-08-11 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | Structure of duplex DNA containing the cisplatin 1,2-{Pt(NH(3))(2)}(2+)-d(GpG) cross-link at 1.77A resolution.
J.Inorg.Biochem., 104, 2010
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3M4O
 | | RNA polymerase II elongation complex B | | Descriptor: | DNA (28-MER), DNA (5'-D(P*GP*TP*GP*GP*TP*TP*AP*TP*GP*GP*GP*TP*AP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, ... | | Authors: | Wang, D, Zhu, G, Huang, X, Lippard, S.J. | | Deposit date: | 2010-03-11 | | Release date: | 2010-05-12 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (3.57 Å) | | Cite: | X-ray structure and mechanism of RNA polymerase II stalled at an antineoplastic monofunctional platinum-DNA adduct.
Proc.Natl.Acad.Sci.USA, 107, 2010
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3N1X
 | | X-ray Crystal Structure of Toluene/o-Xylene Monooxygenase Hydroxylase T201C Mutant | | Descriptor: | 1,2-ETHANEDIOL, FE (III) ION, HYDROXIDE ION, ... | | Authors: | Sazinsky, M.H, McCormick, M.S, Lippard, S.J. | | Deposit date: | 2010-05-17 | | Release date: | 2010-10-13 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Active Site Threonine Facilitates Proton Transfer during Dioxygen Activation at the Diiron Center of Toluene/o-Xylene Monooxygenase Hydroxylase.
J.Am.Chem.Soc., 132, 2010
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3N1Y
 | | X-ray Crystal Structure of Toluene/o-Xylene Monooxygenase Hydroxylase T201G Mutant | | Descriptor: | FE (III) ION, GLYCEROL, HEXAETHYLENE GLYCOL, ... | | Authors: | McCormick, M.S, Sazinsky, M.H, Lippard, S.J. | | Deposit date: | 2010-05-17 | | Release date: | 2010-10-13 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Active Site Threonine Facilitates Proton Transfer during Dioxygen Activation at the Diiron Center of Toluene/o-Xylene Monooxygenase Hydroxylase.
J.Am.Chem.Soc., 132, 2010
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3N1Z
 | | X-ray Crystal Structure of Toluene/o-Xylene Monooxygenase Hydroxylase T201S Mutant | | Descriptor: | FE (III) ION, GLYCEROL, HEXAETHYLENE GLYCOL, ... | | Authors: | McCormick, M.S, Sazinsky, M.H, Lippard, S.J. | | Deposit date: | 2010-05-17 | | Release date: | 2010-10-13 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Active Site Threonine Facilitates Proton Transfer during Dioxygen Activation at the Diiron Center of Toluene/o-Xylene Monooxygenase Hydroxylase.
J.Am.Chem.Soc., 132, 2010
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3N20
 | | X-ray Crystal Structure of Toluene/o-Xylene Monooxygenase Hydroxylase T201V Mutant | | Descriptor: | FE (III) ION, GLYCEROL, HEXAETHYLENE GLYCOL, ... | | Authors: | McCormick, M.S, Sazinsky, M.H, Lippard, S.J. | | Deposit date: | 2010-05-17 | | Release date: | 2010-10-13 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Active Site Threonine Facilitates Proton Transfer during Dioxygen Activation at the Diiron Center of Toluene/o-Xylene Monooxygenase Hydroxylase.
J.Am.Chem.Soc., 132, 2010
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3M3Y
 | | RNA polymerase II elongation complex C | | Descriptor: | DNA (28-MER), DNA (5'-D(*GP*TP*GP*GP*TP*TP*AP*TP*GP*GP*GP*TP*AP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, ... | | Authors: | Wang, D, Zhu, G, Huang, X, Lippard, S.J. | | Deposit date: | 2010-03-10 | | Release date: | 2010-05-12 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (3.18 Å) | | Cite: | X-ray structure and mechanism of RNA polymerase II stalled at an antineoplastic monofunctional platinum-DNA adduct.
Proc.Natl.Acad.Sci.USA, 107, 2010
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1T0R
 | | Crystal Structure of the Toluene/o-xylene Monooxygenase Hydroxuylase from Pseudomonas stutzeri-azide bound | | Descriptor: | AZIDE ION, FE (III) ION, HYDROXIDE ION, ... | | Authors: | Sazinsky, M.H, Bard, J, Di Donato, A, Lippard, S.J. | | Deposit date: | 2004-04-12 | | Release date: | 2004-07-27 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal Structure of the Toluene/o-Xylene Monooxygenase Hydroxylase from Pseudomonas stutzeri OX1: INSIGHT INTO THE SUBSTRATE SPECIFICITY, SUBSTRATE CHANNELING, AND ACTIVE SITE TUNING OF MULTICOMPONENT MONOOXYGENASES.
J.Biol.Chem., 279, 2004
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1TVC
 | | FAD and NADH binding domain of methane monooxygenase reductase from Methylococcus capsulatus (Bath) | | Descriptor: | DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, METHANE MONOOXYGENASE COMPONENT C | | Authors: | Chatwood, L.L, Mueller, J, Gross, J.D, Wagner, G, Lippard, S.J. | | Deposit date: | 2004-06-29 | | Release date: | 2004-10-12 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | NMR Structure of the Flavin Domain from Soluble Methane Monooxygenase Reductase from Methylococcus capsulatus (Bath)
Biochemistry, 43, 2004
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1T0S
 | | Structure of the Toluene/o-Xylene Monooxygenase Hydroxylase with 4-bromophenol bound | | Descriptor: | 4-BROMOPHENOL, FE (III) ION, HYDROXIDE ION, ... | | Authors: | Sazinsky, M.H, Bard, J, Di Donato, A, Lippard, S.J. | | Deposit date: | 2004-04-12 | | Release date: | 2004-07-27 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal Structure of the Toluene/o-Xylene Monooxygenase Hydroxylase from Pseudomonas stutzeri OX1: INSIGHT INTO THE SUBSTRATE SPECIFICITY, SUBSTRATE CHANNELING, AND ACTIVE SITE TUNING OF MULTICOMPONENT MONOOXYGENASES.
J.Biol.Chem., 279, 2004
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