3M4O

RNA polymerase II elongation complex B

Summary for 3M4O

• Entry DOI: 10.2210/pdb3m4o/pdb
• Related: 1R9T 2E2H 3CO3 3M3Y
• Descriptor: DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerases I, II, and III subunit RPABC4, RNA (5'-R(*AP*UP*GP*GP*AP*GP*AP*GP*GP*A)-3'), ... (16 entities in total)
• Functional Keywords: transcription, mrna, multiprotein complex, molecular machine, dna, dna damage, cancer, platinum drug, dna-binding, dna-directed rna polymerase, isopeptide bond, magnesium, metal-binding, nucleotidyltransferase, nucleus, phosphoprotein, transferase, ubl conjugation, zinc, zinc-finger, polymorphism, cytoplasm, dna repair, transferase-dna-rna hybrid complex, transferase/dna-rna hybrid
• Biological source: Saccharomyces cerevisiae (brewer's yeast,lager beer yeast,yeast); More
• Cellular location: Nucleus: P04050 P08518 P16370 P20434 P20436 P27999 P38902; Nucleus, nucleolus: P40422 P22139; Cytoplasm: P20435
• Total number of polymer chains: 13
• Total formula weight: 486554.54

Authors

Wang, D.,Zhu, G.,Huang, X.,Lippard, S.J. (deposition date: 2010-03-11, release date: 2010-05-12, Last modification date: 2023-09-06)

• Primary citation: Wang, D.,Zhu, G.,Huang, X.,Lippard, S.J.; X-ray structure and mechanism of RNA polymerase II stalled at an antineoplastic monofunctional platinum-DNA adduct.; Proc.Natl.Acad.Sci.USA, 107:9584-9589, 2010; PubMed: 20448203; DOI: 10.1073/pnas.1002565107

Experimental method

X-RAY DIFFRACTION (3.57 Å)