1AIO

CRYSTAL STRUCTURE OF A DOUBLE-STRANDED DNA CONTAINING THE MAJOR ADDUCT OF THE ANTICANCER DRUG CISPLATIN

Replaces:  1GPG

Summary for 1AIO

• Entry DOI: 10.2210/pdb1aio/pdb
• Descriptor: DNA (5'-D(*CP*CP*(BRU)P*CP*TP*[PT(NH3)2(GP*GP)]*TP*CP*TP*CP*C)-3'), DNA (5'-D(*GP*GP*AP*GP*AP*CP*CP*AP*GP*AP*GP*G)-3'), Cisplatin, ... (4 entities in total)
• Functional Keywords: right handed dna, double helix, complexed with drug, modified, dna
• Total number of polymer chains: 4
• Total formula weight: 15383.40

Authors

Takahara, P.M.,Rosenzweig, A.C.,Frederick, C.A.,Lippard, S.J. (deposition date: 1997-04-23, release date: 1997-04-24, Last modification date: 2024-02-07)

• Primary citation: Takahara, P.M.,Rosenzweig, A.C.,Frederick, C.A.,Lippard, S.J.; Crystal structure of double-stranded DNA containing the major adduct of the anticancer drug cisplatin.; Nature, 377:649-652, 1995; PubMed: 7566180; DOI: 10.1038/377649a0

Experimental method

X-RAY DIFFRACTION (2.6 Å)