1N4M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1n4m by Molmil](/molmil-images/mine/1n4m) | Structure of Rb tumor suppressor bound to the transactivation domain of E2F-2 | Descriptor: | Retinoblastoma Pocket, Transcription factor E2F2 | Authors: | Lee, C, Chang, J.H, Lee, H.S, Cho, Y. | Deposit date: | 2002-10-31 | Release date: | 2003-01-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor GENES DEV., 16, 2002
|
|
3MKR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3mkr by Molmil](/molmil-images/mine/3mkr) | |
4Z1I
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4z1i by Molmil](/molmil-images/mine/4z1i) | Crystal structure of human Trap1 with AMPPNP | Descriptor: | Heat shock protein 75 kDa, mitochondrial, MAGNESIUM ION, ... | Authors: | Lee, C, Park, H.K, Ryu, J.H, Kang, B.H. | Deposit date: | 2015-03-27 | Release date: | 2015-04-29 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Development of a Mitochondria-Targeted Hsp90 Inhibitor Based on the Crystal Structures of Human TRAP1 J.Am.Chem.Soc., 137, 2015
|
|
4Z1H
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4z1h by Molmil](/molmil-images/mine/4z1h) | Crystal structure of human Trap1 with SMTIN-P01 | Descriptor: | 8-[(6-iodo-1,3-benzodioxol-5-yl)sulfanyl]-9-[6-(triphenyl-lambda~5~-phosphanyl)hexyl]-9H-purin-6-amine, Heat shock protein 75 kDa, mitochondrial | Authors: | Lee, C, Park, H.K, Ryu, J.H, Kang, B.H. | Deposit date: | 2015-03-27 | Release date: | 2015-04-22 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Development of a Mitochondria-Targeted Hsp90 Inhibitor Based on the Crystal Structures of Human TRAP1 J.Am.Chem.Soc., 137, 2015
|
|
4Z1G
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4z1g by Molmil](/molmil-images/mine/4z1g) | Crystal structure of human Trap1 with BIIB-021 | Descriptor: | 6-chloro-9-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-9H-purin-2-amine, Heat shock protein 75 kDa, mitochondrial | Authors: | Lee, C, Park, H.K, Ryu, J.H, Kang, B.H. | Deposit date: | 2015-03-27 | Release date: | 2015-04-22 | Last modified: | 2022-10-05 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Development of a Mitochondria-Targeted Hsp90 Inhibitor Based on the Crystal Structures of Human TRAP1 J.Am.Chem.Soc., 137, 2015
|
|
4Z1F
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4z1f by Molmil](/molmil-images/mine/4z1f) | Crystal structure of human Trap1 with PU-H71 | Descriptor: | 8-[(6-IODO-1,3-BENZODIOXOL-5-YL)THIO]-9-[3-(ISOPROPYLAMINO)PROPYL]-9H-PURIN-6-AMINE, Heat shock protein 75 kDa, mitochondrial | Authors: | Lee, C, Park, H.K, Ryu, J.H, Kang, B.H. | Deposit date: | 2015-03-27 | Release date: | 2015-04-22 | Method: | X-RAY DIFFRACTION (2.703 Å) | Cite: | Development of a Mitochondria-Targeted Hsp90 Inhibitor Based on the Crystal Structures of Human TRAP1 J.Am.Chem.Soc., 137, 2015
|
|
1IZ3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1iz3 by Molmil](/molmil-images/mine/1iz3) | Dimeric structure of FIH (Factor inhibiting HIF) | Descriptor: | FIH, SULFATE ION | Authors: | Lee, C, Kim, S.-J, Jeong, D.-G, Lee, S.M, Ryu, S.-E. | Deposit date: | 2002-09-19 | Release date: | 2003-06-10 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of human FIH-1 reveals a unique active site pocket and interaction sites for HIF-1 and von Hippel-Lindau. J.Biol.Chem., 278, 2003
|
|
4BWZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4bwz by Molmil](/molmil-images/mine/4bwz) | |
5VRE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5vre by Molmil](/molmil-images/mine/5vre) | |
3MKQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3mkq by Molmil](/molmil-images/mine/3mkq) | |
5H20
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5h20 by Molmil](/molmil-images/mine/5h20) | X-ray structure of PadR-like Transcription factor from bacteroid fragilis | Descriptor: | ISOPROPYL ALCOHOL, PHOSPHATE ION, Putative PadR-family transcriptional regulatory protein, ... | Authors: | Lee, C, Hong, M. | Deposit date: | 2016-10-13 | Release date: | 2017-03-08 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural and functional analysis of BF2549, a PadR-like transcription factor from Bacteroides fragilis. Biochem. Biophys. Res. Commun., 483, 2017
|
|
5XEF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5xef by Molmil](/molmil-images/mine/5xef) | Crystal structure of flagellar chaperone from bacteria | Descriptor: | Flagellar protein fliS | Authors: | Lee, C, Hong, M. | Deposit date: | 2017-04-05 | Release date: | 2018-06-27 | Last modified: | 2019-02-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of the flagellar chaperone FliS from Bacillus cereus and an invariant proline critical for FliS dimerization and flagellin recognition Biochem. Biophys. Res. Commun., 487, 2017
|
|
6ABT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6abt by Molmil](/molmil-images/mine/6abt) | Crystal structure of transcription factor from Listeria monocytogenes | Descriptor: | PadR family transcriptional regulator | Authors: | Lee, C, Hong, M. | Deposit date: | 2018-07-23 | Release date: | 2019-06-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure-based molecular characterization and regulatory mechanism of the LftR transcription factor from Listeria monocytogenes: Conformational flexibilities and a ligand-induced regulatory mechanism. Plos One, 14, 2019
|
|
6ABQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6abq by Molmil](/molmil-images/mine/6abq) | Crystal structure of transcription factor from Listeria monocytogenes | Descriptor: | CHLORIDE ION, PadR family transcriptional regulator | Authors: | Lee, C, Hong, M. | Deposit date: | 2018-07-23 | Release date: | 2019-06-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure-based molecular characterization and regulatory mechanism of the LftR transcription factor from Listeria monocytogenes: Conformational flexibilities and a ligand-induced regulatory mechanism. Plos One, 14, 2019
|
|
2JRL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2jrl by Molmil](/molmil-images/mine/2jrl) | Solution structure of the beryllofluoride-activated NtrC4 receiver domain dimer | Descriptor: | Transcriptional regulator (NtrC family) | Authors: | Lee, C, Hong, E, Doucleff, M, Pelton, J.G, Wemmer, D.E, Berkeley Structural Genomics Center (BSGC) | Deposit date: | 2007-06-27 | Release date: | 2008-07-01 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution Structure of the Beryllofluoride-Activated NtrC4 Receiver Domain Dimer. To be Published
|
|
4AU5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4au5 by Molmil](/molmil-images/mine/4au5) | Structure of the NhaA dimer, crystallised at low pH | Descriptor: | DODECYL-ALPHA-D-MALTOSIDE, NA(+)/H(+) ANTIPORTER NHAA, SULFATE ION | Authors: | Drew, D, Lee, C, Iwata, S, Cameron, A.D. | Deposit date: | 2012-05-14 | Release date: | 2013-07-10 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.696 Å) | Cite: | Crystal structure of the sodium-proton antiporter NhaA dimer and new mechanistic insights. J. Gen. Physiol., 144, 2014
|
|
4ATV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4atv by Molmil](/molmil-images/mine/4atv) | STRUCTURE OF A TRIPLE MUTANT OF THE NHAA DIMER, CRYSTALLISED AT LOW PH | Descriptor: | DODECYL-ALPHA-D-MALTOSIDE, NA(+)/H(+) ANTIPORTER NHAA, SULFATE ION | Authors: | Drew, D, Lee, C, Iwata, S, Cameron, A.D. | Deposit date: | 2012-05-10 | Release date: | 2013-07-10 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Crystal structure of the sodium-proton antiporter NhaA dimer and new mechanistic insights. J. Gen. Physiol., 144, 2014
|
|
2ZXX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2zxx by Molmil](/molmil-images/mine/2zxx) | Crystal structure of Cdt1/geminin complex | Descriptor: | DNA replication factor Cdt1, Geminin | Authors: | Cho, Y, Lee, C, Hong, B.S, Choi, J.M. | Deposit date: | 2009-01-08 | Release date: | 2009-02-17 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural basis for inhibition of the replication licensing factor Cdt1 by geminin Nature, 430, 2004
|
|
2JTN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2jtn by Molmil](/molmil-images/mine/2jtn) | NMR Solution Structure of a ldb1-LID:Lhx3-LIM complex | Descriptor: | LIM domain-binding protein 1, LIM/homeobox protein Lhx3, ZINC ION | Authors: | Lee, C, Nancarrow, A.L, Mackay, J.P, Matthews, J.M. | Deposit date: | 2007-08-03 | Release date: | 2008-06-17 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes Embo J., 27, 2008
|
|
2HIW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2hiw by Molmil](/molmil-images/mine/2hiw) | |
4ZTT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ztt by Molmil](/molmil-images/mine/4ztt) | Crystal structures of ferritin mutants reveal diferric-peroxo intermediates | Descriptor: | Bacterial non-heme ferritin, FE (II) ION, FE (III) ION, ... | Authors: | Kim, S, Park, Y.H, Jung, S.W, Seok, J.H, Chung, Y.B, Lee, D.B, Gowda, G, Lee, J.H, Han, H.R, Cho, A.E, Lee, C, Chung, M.S, Kim, K.H. | Deposit date: | 2015-05-15 | Release date: | 2016-06-15 | Last modified: | 2020-02-19 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Structural Basis of Novel Iron-Uptake Route and Reaction Intermediates in Ferritins from Gram-Negative Bacteria. J. Mol. Biol., 428, 2016
|
|
5Y3N
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5y3n by Molmil](/molmil-images/mine/5y3n) | Structure of TRAP1 complexed with DN401 | Descriptor: | 1-[(6-bromanyl-1,3-benzodioxol-5-yl)methyl]-4-chloranyl-pyrazolo[3,4-d]pyrimidin-6-amine, Heat shock protein 75 kDa, mitochondrial | Authors: | Jeong, H, Park, H.K, Kang, S, Kang, B.H, Lee, C. | Deposit date: | 2017-07-29 | Release date: | 2017-08-30 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Paralog Specificity Determines Subcellular Distribution, Action Mechanism, and Anticancer Activity of TRAP1 Inhibitors. J. Med. Chem., 60, 2017
|
|
5Y3O
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5y3o by Molmil](/molmil-images/mine/5y3o) | Structure of TRAP1 complexed with DN320 | Descriptor: | 4-chloranyl-1-[(4-methoxy-3,5-dimethyl-pyridin-2-yl)methyl]pyrazolo[3,4-d]pyrimidin-6-amine, Heat shock protein 75 kDa, mitochondrial | Authors: | Jeong, H, Park, H.K, Kang, S, Kang, B.H, Lee, C. | Deposit date: | 2017-07-29 | Release date: | 2017-08-30 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Paralog Specificity Determines Subcellular Distribution, Action Mechanism, and Anticancer Activity of TRAP1 Inhibitors. J. Med. Chem., 60, 2017
|
|
5C6F
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5c6f by Molmil](/molmil-images/mine/5c6f) | Crystal structures of ferritin mutants reveal side-on binding to diiron and end-on cleavage of oxygen | Descriptor: | Bacterial non-heme ferritin, FE (III) ION, IMIDAZOLE | Authors: | Kim, S, Kim, K.H, Seok, J.H, Park, Y.H, Jung, S.W, Chung, Y.B, Lee, D.B, Lee, J.H, Han, K.R, Cho, A.E, Lee, C, Chung, M.S. | Deposit date: | 2015-06-23 | Release date: | 2016-07-27 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Basis of Novel Iron-Uptake Route and Reaction Intermediates in Ferritins from Gram-Negative Bacteria. J. Mol. Biol., 428, 2016
|
|
7C04
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7c04 by Molmil](/molmil-images/mine/7c04) | Crystal structure of human Trap1 with DN203492 | Descriptor: | 4-chloranyl-1-[[2-methoxy-4-(trifluoromethyl)phenyl]methyl]pyrazolo[3,4-d]pyrimidin-6-amine, Heat shock protein 75 kDa, mitochondrial | Authors: | Kim, D, Kim, D, Kim, S.Y, Lee, J.H, Kang, B.H, Kang, S, Lee, C. | Deposit date: | 2020-04-30 | Release date: | 2020-07-08 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Development of pyrazolo[3,4-d]pyrimidine-6-amine-based TRAP1 inhibitors that demonstrate in vivo anticancer activity in mouse xenograft models. Bioorg.Chem., 101, 2020
|
|