2HIW
Crystal Structure of Inactive Conformation Abl Kinase Catalytic Domain Complexed with Type II Inhibitor
Summary for 2HIW
Entry DOI | 10.2210/pdb2hiw/pdb |
Descriptor | Proto-oncogene tyrosine-protein kinase ABL1, 7-AMINO-1-METHYL-3-(2-METHYL-5-{[3-(TRIFLUOROMETHYL)BENZOYL]AMINO}PHENYL)-2-OXO-2,3-DIHYDROPYRIMIDO[4,5-D]PYRIMIDIN-1-IUM (3 entities in total) |
Functional Keywords | kinase domain, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytoskeleton. Isoform IB: Nucleus membrane; Lipid-anchor: P00519 |
Total number of polymer chains | 2 |
Total formula weight | 67278.69 |
Authors | |
Primary citation | Okram, B.,Nagle, A.,Adrian, F.J.,Lee, C.,Ren, P.,Wang, X.,Sim, T.,Xie, Y.,Wang, X.,Xia, G.,Spraggon, G.,Warmuth, M.,Liu, Y.,Gray, N.S. A general strategy for creating Chem.Biol., 13:779-786, 2006 Cited by PubMed: 16873026DOI: 10.1016/j.chembiol.2006.05.015 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
Download full validation report