2HIW
Crystal Structure of Inactive Conformation Abl Kinase Catalytic Domain Complexed with Type II Inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Proto-oncogene tyrosine-protein kinase ABL1 | polymer | 287 | 33183.9 | 2 | UniProt (P00519) Pfam (PF07714) | Homo sapiens (human) | p150, c-ABL, Abelson murine leukemia viral oncogene homolog 1 |
| 2 | C, D (A, B) | 7-AMINO-1-METHYL-3-(2-METHYL-5-{[3-(TRIFLUOROMETHYL)BENZOYL]AMINO}PHENYL)-2-OXO-2,3-DIHYDROPYRIMIDO[4,5-D]PYRIMIDIN-1-IUM | non-polymer | 455.4 | 2 | Chemie (7MP) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 224 | Chemie (HOH) |
Sequence modifications
A, B: 248 - 530 (UniProt: P00519)
| PDB | External Database | Details |
|---|---|---|
| Gly 244 | - | cloning artifact |
| Ala 245 | - | cloning artifact |
| Met 246 | - | cloning artifact |
| Asp 247 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 66367.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 910.8 | |
| All* | Total formula weight | 67278.7 |
