2HIW
Crystal Structure of Inactive Conformation Abl Kinase Catalytic Domain Complexed with Type II Inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Proto-oncogene tyrosine-protein kinase ABL1 | polymer | 287 | 33183.9 | 2 | UniProt (P00519) Pfam (PF07714) In PDB | Homo sapiens (human) | p150, c-ABL, Abelson murine leukemia viral oncogene homolog 1 |
2 | A, B | 7-AMINO-1-METHYL-3-(2-METHYL-5-{[3-(TRIFLUOROMETHYL)BENZOYL]AMINO}PHENYL)-2-OXO-2,3-DIHYDROPYRIMIDO[4,5-D]PYRIMIDIN-1-IUM | non-polymer | 455.4 | 2 | Chemie (7MP) | |||
3 | water | water | 18.0 | 224 | Chemie (HOH) |
Sequence modifications
A, B: 248 - 530 (UniProt: P00519)
PDB | External Database | Details |
---|---|---|
Gly 244 | - | cloning artifact |
Ala 245 | - | cloning artifact |
Met 246 | - | cloning artifact |
Asp 247 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 66367.9 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 910.8 | |
All* | Total formula weight | 67278.7 |