5Y3O

Structure of TRAP1 complexed with DN320

Summary for 5Y3O

Entry DOI	10.2210/pdb5y3o/pdb
Descriptor	Heat shock protein 75 kDa, mitochondrial, 4-chloranyl-1-[(4-methoxy-3,5-dimethyl-pyridin-2-yl)methyl]pyrazolo[3,4-d]pyrimidin-6-amine (3 entities in total)
Functional Keywords	trap1, inhibitor, dn320, mitochondrial hsp90, chaperone
Biological source	Homo sapiens (Human)
Cellular location	Mitochondrion : Q12931
Total number of polymer chains	1
Total formula weight	57740.85
Authors	Jeong, H.,Park, H.K.,Kang, S.,Kang, B.H.,Lee, C. (deposition date: 2017-07-29, release date: 2017-08-30, Last modification date: 2024-03-27)
Primary citation	Park, H.K.,Jeong, H.,Ko, E.,Lee, G.,Lee, J.E.,Lee, S.K.,Lee, A.J.,Im, J.Y.,Hu, S.,Kim, S.H.,Lee, J.H.,Lee, C.,Kang, S.,Kang, B.H. Paralog Specificity Determines Subcellular Distribution, Action Mechanism, and Anticancer Activity of TRAP1 Inhibitors. J. Med. Chem., 60:7569-7578, 2017 Cited by PubMed: 28816449 DOI: 10.1021/acs.jmedchem.7b00978 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation