2W1Z
| ROP2 from Toxoplasma gondii: A virulence factor with a protein- kinase fold and no enzymatic activity. | 分子名称: | ROP2, SULFATE ION | 著者 | Labesse, G, Gelin, M, Bessin, Y, Lebrun, M, Arold, S.T, Dubremetz, J.-F. | 登録日 | 2008-10-21 | 公開日 | 2008-12-09 | 最終更新日 | 2011-09-21 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Rop2 from Toxoplasma Gondii: A Virulence Factor with a Protein-Kinase Fold and No Enzymatic Activity. Structure, 17, 2009
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4DQW
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3NWY
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5AHM
| IMP-bound form of the DeltaCBS mutant of IMPDH from Pseudomonas aeruginosa | 分子名称: | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE, INOSINIC ACID, PHOSPHATE ION | 著者 | Labesse, G, Alexandre, T, Gelin, M, Haouz, A, Munier-Lehmann, H. | 登録日 | 2015-02-06 | 公開日 | 2015-07-15 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Crystallographic Studies of Two Variants of Pseudomonas Aeruginosa Impdh with Impaired Allosteric Regulation Acta Crystallogr.,Sect.D, 71, 2015
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5AHN
| IMP-bound form of the D199N mutant of IMPDH from Pseudomonas aeruginosa | 分子名称: | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE, INOSINIC ACID, MAGNESIUM ION | 著者 | Labesse, G, Alexandre, T, Gelin, M, Haouz, A, Munier-Lehmann, H. | 登録日 | 2015-02-06 | 公開日 | 2015-07-15 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.652 Å) | 主引用文献 | Crystallographic Studies of Two Variants of Pseudomonas Aeruginosa Impdh with Impaired Allosteric Regulation Acta Crystallogr.,Sect.D, 71, 2015
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5AHL
| Apo-form of the DeltaCBS mutant of IMPDH from Pseudomonas aeruginosa | 分子名称: | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE, SODIUM ION | 著者 | Labesse, G, Alexandre, T, Gelin, M, Haouz, A, Munier-Lehmann, H. | 登録日 | 2015-02-06 | 公開日 | 2015-07-15 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.951 Å) | 主引用文献 | Crystallographic Studies of Two Variants of Pseudomonas Aeruginosa Impdh with Impaired Allosteric Regulation Acta Crystallogr.,Sect.D, 71, 2015
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7QBJ
| bacterial IMPDH chimera | 分子名称: | Inosine-5'-monophosphate dehydrogenase | 著者 | Labesse, G, Gelin, M, Munier-Lehmann, H, Gedeon, A, Haouz, A. | 登録日 | 2021-11-19 | 公開日 | 2023-05-31 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | 主引用文献 | Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMP dehydrogenases. Protein Sci., 32, 2023
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7QDX
| bacterial IMPDH chimera | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Inosine-5'-monophosphate dehydrogenase, MAGNESIUM ION | 著者 | Labesse, G, Gelin, M, Munier-Lehmann, H, Gedeon, A, Haouz, A. | 登録日 | 2021-11-30 | 公開日 | 2023-06-14 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMP dehydrogenases. Protein Sci., 32, 2023
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7R4J
| Crystal structure of human mitochondrial NAD kinase | 分子名称: | CALCIUM ION, NAD kinase 2, mitochondrial | 著者 | Labesse, G, Mary, C, Gelin, M, Lionne, C. | 登録日 | 2022-02-08 | 公開日 | 2022-07-06 | 最終更新日 | 2022-09-14 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Crystal structure of human NADK2 reveals a dimeric organization and active site occlusion by lysine acetylation. Mol.Cell, 82, 2022
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7R4L
| Crystal structure of human mitochondrial NAD kinase | 分子名称: | FE (III) ION, NAD kinase 2, mitochondrial, ... | 著者 | Labesse, G, Mary, C, Gelin, M, Lionne, C. | 登録日 | 2022-02-08 | 公開日 | 2022-07-06 | 最終更新日 | 2022-09-14 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal structure of human NADK2 reveals a dimeric organization and active site occlusion by lysine acetylation. Mol.Cell, 82, 2022
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7R4K
| Crystal structure of human mitochondrial NAD kinase | 分子名称: | MAGNESIUM ION, NAD kinase 2, mitochondrial, ... | 著者 | Labesse, G, Mary, C, Gelin, M, Lionne, C. | 登録日 | 2022-02-08 | 公開日 | 2022-07-06 | 最終更新日 | 2022-09-14 | 実験手法 | X-RAY DIFFRACTION (3.33 Å) | 主引用文献 | Crystal structure of human NADK2 reveals a dimeric organization and active site occlusion by lysine acetylation. Mol.Cell, 82, 2022
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7R4M
| Crystal structure of mitochondrial NAD kinase | 分子名称: | CALCIUM ION, NAD kinase 2, mitochondrial, ... | 著者 | Labesse, G, Mary, C, Gelin, M, Lionne, C. | 登録日 | 2022-02-08 | 公開日 | 2022-07-06 | 最終更新日 | 2022-09-14 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | Crystal structure of human NADK2 reveals a dimeric organization and active site occlusion by lysine acetylation. Mol.Cell, 82, 2022
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7QEM
| bacterial IMPDH chimera | 分子名称: | INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase | 著者 | Labesse, G, Gelin, M, Gedeon, A, Haouz, A, Munier-Lehmann, H. | 登録日 | 2021-12-03 | 公開日 | 2023-06-14 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (3.09 Å) | 主引用文献 | Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMP dehydrogenases. Protein Sci., 32, 2023
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7BIX
| Crystal structure of UMPK from M. tuberculosis in complex with UDP and UTP (C2 form) | 分子名称: | URIDINE 5'-TRIPHOSPHATE, URIDINE-5'-DIPHOSPHATE, Uridylate kinase | 著者 | Labesse, G, Walter, P, Haouz, A, Mechaly, A.E, Munier-Lehmann, H. | 登録日 | 2021-01-13 | 公開日 | 2022-03-02 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.12 Å) | 主引用文献 | Structural basis for the allosteric inhibition of UMP kinase from Gram-positive bacteria, a promising antibacterial target. Febs J., 289, 2022
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4FYH
| Crystal structure of rcl with phospho-triciribine | 分子名称: | 5-methyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-1,5-dihydro-1,4,5,6,8-pentaazaacenaphthylen-3-amine, Deoxyribonucleoside 5'-monophosphate N-glycosidase, SULFATE ION | 著者 | Labesse, G, Padilla, A, Kaminski, P.A. | 登録日 | 2012-07-04 | 公開日 | 2013-01-02 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | 主引用文献 | Structure of the oncoprotein Rcl bound to three nucleotide analogues. Acta Crystallogr.,Sect.D, 69, 2013
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4FYK
| Crystal structure of rcl with 5'-phiosphorothioate-adenosine | 分子名称: | ADENOSINE -5'-THIO-MONOPHOSPHATE, Deoxyribonucleoside 5'-monophosphate N-glycosidase, SULFATE ION | 著者 | Labesse, G, Padilla, A, Kaminski, P.A. | 登録日 | 2012-07-04 | 公開日 | 2013-01-02 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Structure of the oncoprotein Rcl bound to three nucleotide analogues. Acta Crystallogr.,Sect.D, 69, 2013
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4FYI
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2I2A
| Crystal structure of LmNADK1 from Listeria monocytogenes | 分子名称: | GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Probable inorganic polyphosphate/ATP-NAD kinase 1 | 著者 | Labesse, G. | 登録日 | 2006-08-16 | 公開日 | 2007-08-07 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | NAD kinases use substrate-assisted catalysis for specific recognition of NAD. J.Biol.Chem., 282, 2007
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6GK9
| Inhibited structure of IMPDH from Pseudomonas aeruginosa | 分子名称: | (5~{S})-7-azanyl-5-(4-chlorophenyl)-2,4-bis(oxidanylidene)-1,5-dihydropyrano[2,3-d]pyrimidine-6-carbonitrile, Inosine-5'-monophosphate dehydrogenase, SULFATE ION | 著者 | Labesse, G, Alexandre, T, Haouz, A, Munier-Lehmann, H. | 登録日 | 2018-05-18 | 公開日 | 2019-02-27 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | 主引用文献 | First-in-class allosteric inhibitors of bacterial IMPDHs. Eur J Med Chem, 167, 2019
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6GJV
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7P3V
| B-Raf V600E structure bound to a new inhibitor | 分子名称: | Serine/threonine-protein kinase B-raf, ~{N}-[3-[5-(2-azanylpyrimidin-4-yl)-2-[(3~{S})-morpholin-3-yl]-1,3-thiazol-4-yl]-2-fluoranyl-phenyl]-2,5-bis(fluoranyl)benzenesulfonamide | 著者 | Schneider, M, Gelin, M, Cohen-Gonsaud, M, Labesse, G. | 登録日 | 2021-07-08 | 公開日 | 2021-11-03 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.37 Å) | 主引用文献 | Structure-Based and Knowledge-Informed Design of B-Raf Inhibitors Devoid of Deleterious PXR Binding. J.Med.Chem., 65, 2022
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4U77
| BTB domain from Drosophila CP190 | 分子名称: | Centrosome-associated zinc finger protein CP190, DIMETHYL SULFOXIDE, GLYCEROL | 著者 | Allemand, F, Cohen-Gonsaud, M, Labesse, G, Nollmann, M. | 登録日 | 2014-07-30 | 公開日 | 2014-08-13 | 最終更新日 | 2014-10-15 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Chromatin Insulator Factors Involved in Long-Range DNA Interactions and Their Role in the Folding of the Drosophila Genome. Plos Genet., 10, 2014
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4DY6
| Crystal structure of NAD kinase 1 from Listeria monocytogenes in complex with 2'-phosphate bis(adenosine)-5'-diphosphate | 分子名称: | CITRIC ACID, [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL [(2R,3R,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3-HYDROXY-4-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN DIPHOSPHATE, inorganic polyphosphate/ATP-NAD kinase 1 | 著者 | Poncet-Montange, G, Assairi, L, Arold, S, Pochet, S, Labesse, G. | 登録日 | 2012-02-28 | 公開日 | 2012-03-07 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | NAD kinases use substrate-assisted catalysis for specific recognition of NAD. J.Biol.Chem., 282, 2007
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4KXM
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4KXL
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