2CMO
| The structure of a mixed glur2 ligand-binding core dimer in complex with (s)-glutamate and the antagonist (s)-ns1209 | 分子名称: | 2-({[(3E)-5-{4-[(DIMETHYLAMINO)(DIHYDROXY)-LAMBDA~4~-SULFANYL]PHENYL}-8-METHYL-2-OXO-6,7,8,9-TETRAHYDRO-1H-PYRROLO[3,2-H]ISOQUINOLIN-3(2H)-YLIDENE]AMINO}OXY)-4-HYDROXYBUTANOIC ACID, GLUTAMATE RECEPTOR 2, GLUTAMIC ACID, ... | 著者 | Kasper, C, Pickering, D.S, Mirza, O, Olsen, L, Kristensen, A.S, Greenwood, J.R, Liljefors, T, Schousboe, A, Watjen, F, Gajhede, M, Sigurskjold, B.W, Kastrup, J.S. | 登録日 | 2006-05-11 | 公開日 | 2006-06-06 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | The Structure of a Mixed Glur2 Ligand-Binding Core Dimer in Complex with (S)-Glutamate and the Antagonist (S)-Ns1209. J.Mol.Biol., 357, 2006
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5CC2
| STRUCTURE OF THE LIGAND-BINDING DOMAIN OF THE IONOTROPIC GLUTAMATE RECEPTOR-LIKE GLUD2 IN COMPLEX WITH 7-CKA | 分子名称: | 7-Chlorokynurenic acid, CHLORIDE ION, GLYCEROL, ... | 著者 | Naur, P, Gajhede, M, Kastrup, J.S. | 登録日 | 2015-07-01 | 公開日 | 2015-12-30 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.501 Å) | 主引用文献 | Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors. Mol.Pharmacol., 89, 2016
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8QEZ
| Crystal structure of the AMPA receptor GluA2-L504Y-N775S ligand binding domain in complex with L-glutamate and positive allosteric modulator BPAM395 at 1.55A resolution | 分子名称: | 6-chloranyl-4-cyclopropyl-2,3-dihydrothieno[3,2-e][1,2,4]thiadiazine 1,1-dioxide, ACETATE ION, CACODYLATE ION, ... | 著者 | Dorosz, J, Laulumaa, S, Frydenvang, K, Kastrup, J.S. | 登録日 | 2023-09-01 | 公開日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Exploring thienothiadiazine dioxides as isosteric analogues of benzo- and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators. Eur.J.Med.Chem., 264, 2023
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2WKY
| Crystal structure of the ligand-binding core of GluR5 in complex with the agonist 4-AHCP | 分子名称: | 3-(3-HYDROXY-7,8-DIHYDRO-6H-CYCLOHEPTA[D]ISOXAZOL-4-YL)-L-ALANINE, CHLORIDE ION, GLUTAMATE RECEPTOR, ... | 著者 | Naur, P, Gajhede, M, Kastrup, J.S. | 登録日 | 2009-06-18 | 公開日 | 2009-07-21 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The Glutamate Receptor Glur5 Agonist (S)-2-Amino-3-(3-Hydroxy-7,8-Dihydro-6H-Cyclohepta[D]Isoxazol-4-Yl)Propionic Acid and the 8-Methyl Analogue: Synthesis, Molecular Pharmacology, and Biostructural Characterization J.Med.Chem., 52, 2009
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8BSU
| Crystal structure of the kainate receptor GluK3-H523A ligand binding domain in complex with kainate and the positive allosteric modulator BPAM344 at 2.9A resolution | 分子名称: | 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, ACETATE ION, ... | 著者 | Venskutonyte, R, Frydenvang, K, Kastrup, J.S. | 登録日 | 2022-11-26 | 公開日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Positive allosteric modulation of homomeric kainate receptors GluK1-3 To Be Published
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8BST
| Crystal structure of the kainate receptor GluK3-H523A ligand binding domain in complex with kainate at 2.7A resolution | 分子名称: | 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, ACETATE ION, CHLORIDE ION, ... | 著者 | Venskutonyte, R, Frydenvang, K, Kastrup, J.S. | 登録日 | 2022-11-26 | 公開日 | 2023-12-13 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Small-molecule positive allosteric modulation of homomeric kainate receptors GluK1-3: development of screening assays and insight into GluK3 structure. Febs J., 291, 2024
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7PX1
| Conotoxin from Conus mucronatus | 分子名称: | CADMIUM ION, Conus mucronatus, IODIDE ION | 著者 | Mueller, E, Hackney, C.M, Ellgaard, L, Morth, J.P. | 登録日 | 2021-10-07 | 公開日 | 2022-11-02 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | A previously unrecognized superfamily of macro-conotoxins includes an inhibitor of the sensory neuron calcium channel Cav2.3. Plos Biol., 21, 2023
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7PX2
| Conotoxin Mu8.1 from Conus mucronatus | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Conotoxin Mu8.1 | 著者 | Mueller, E, Hackney, C, Ellgaard, L, Morth, J.P. | 登録日 | 2021-10-07 | 公開日 | 2022-11-16 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | A previously unrecognized superfamily of macro-conotoxins includes an inhibitor of the sensory neuron calcium channel Cav2.3. Plos Biol., 21, 2023
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2V3T
| Structure of the ligand-binding core of the ionotropic glutamate receptor-like GluRdelta2 in the apo form | 分子名称: | CALCIUM ION, GLUTAMATE RECEPTOR DELTA-2 SUBUNIT SYNONYM GLURDELTA2, GLUR DELTA-2 | 著者 | Naur, P, Vestergaard, B, Gajhede, M, Kastrup, J.S. | 登録日 | 2007-06-22 | 公開日 | 2007-08-07 | 最終更新日 | 2019-07-24 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Ionotropic Glutamate-Like Receptor {Delta}2 Binds D-Serine and Glycine. Proc.Natl.Acad.Sci.USA, 104, 2007
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2V3U
| Structure of the ligand-binding core of the ionotropic glutamate receptor-like GluRdelta2 in complex with D-serine | 分子名称: | CHLORIDE ION, D-SERINE, GLUTAMATE RECEPTOR DELTA-2 SUBUNIT, ... | 著者 | Naur, P, Vestergaard, B, Gajhede, M, Kastrup, J.S. | 登録日 | 2007-06-22 | 公開日 | 2007-08-07 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Ionotropic Glutamate-Like Receptor {Delta}2 Binds D-Serine and Glycine. Proc.Natl.Acad.Sci.USA, 104, 2007
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3ZRT
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