8QEZ

Crystal structure of the AMPA receptor GluA2-L504Y-N775S ligand binding domain in complex with L-glutamate and positive allosteric modulator BPAM395 at 1.55A resolution

Summary for 8QEZ

Entry DOI	10.2210/pdb8qez/pdb
Descriptor	Glutamate receptor 2, GLUTAMIC ACID, ZINC ION, ... (9 entities in total)
Functional Keywords	ampa receptor ligand-binding domain, glua2 s1s2j-l504y-n775s, bpam395, positive allosteric modulation, membrane protein
Biological source	Rattus norvegicus (Norway rat) More
Total number of polymer chains	3
Total formula weight	90682.77
Authors	Dorosz, J.,Laulumaa, S.,Frydenvang, K.,Kastrup, J.S. (deposition date: 2023-09-01, release date: 2023-12-27)
Primary citation	Francotte, P.,Bay, Y.,Goffin, E.,Colson, T.,Lesenfants, C.,Dorosz, J.,Laulumaa, S.,Fraikin, P.,de Tullio, P.,Beaufour, C.,Botez, I.,Pickering, D.S.,Frydenvang, K.,Danober, L.,Kristensen, A.S.,Kastrup, J.S.,Pirotte, B. Exploring thienothiadiazine dioxides as isosteric analogues of benzo- and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators. Eur.J.Med.Chem., 264:116036-116036, 2023 Cited by PubMed: 38101041 DOI: 10.1016/j.ejmech.2023.116036 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation