3F89
 
 | | NEMO CoZi domain | | Descriptor: | NF-kappa-B essential modulator | | Authors: | Rahighi, S, Ikeda, F, Kawasaki, M, Akutsu, M, Suzuki, N, Kato, R, Kensche, T, Uejima, T, Bloor, S, Komander, D, Randow, F, Wakatsuki, S, Dikic, I. | | Deposit date: | 2008-11-11 | | Release date: | 2009-03-24 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation
Cell(Cambridge,Mass.), 136, 2009
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7OWD
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7OWC
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8UYI
 | | Structure of ADP-bound and phosphorylated Pediculus humanus (Ph) PINK1 dimer | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Serine/threonine-protein kinase Pink1, ... | | Authors: | Gan, Z.Y, Kirk, N.S, Leis, A, Komander, D. | | Deposit date: | 2023-11-13 | | Release date: | 2024-01-31 | | Method: | ELECTRON MICROSCOPY (3.13 Å) | | Cite: | Interaction of PINK1 with nucleotides and kinetin.
Sci Adv, 10, 2024
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8UYH
 | | Structure of AMP-PNP-bound Pediculus humanus (Ph) PINK1 dimer | | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase Pink1, ... | | Authors: | Gan, Z.Y, Kirk, N.S, Leis, A, Komander, D. | | Deposit date: | 2023-11-13 | | Release date: | 2024-01-31 | | Method: | ELECTRON MICROSCOPY (2.84 Å) | | Cite: | Interaction of PINK1 with nucleotides and kinetin.
Sci Adv, 10, 2024
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8UYF
 | | Structure of nucleotide-free Pediculus humanus (Ph) PINK1 dimer | | Descriptor: | Serine/threonine-protein kinase Pink1, mitochondrial | | Authors: | Gan, Z.Y, Kirk, N.S, Leis, A, Komander, D. | | Deposit date: | 2023-11-13 | | Release date: | 2024-01-31 | | Method: | ELECTRON MICROSCOPY (2.75 Å) | | Cite: | Interaction of PINK1 with nucleotides and kinetin.
Sci Adv, 10, 2024
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5C9V
 | | Structure of human Parkin G319A | | Descriptor: | E3 ubiquitin-protein ligase parkin, GLYCEROL, SULFATE ION, ... | | Authors: | Wauer, T, Komander, D. | | Deposit date: | 2015-06-29 | | Release date: | 2015-07-22 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Mechanism of phospho-ubiquitin-induced PARKIN activation.
Nature, 524, 2015
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1H1W
 | | High resolution crystal structure of the human PDK1 catalytic domain | | Descriptor: | 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, ... | | Authors: | Biondi, R.M, Komander, D, Thomas, C.C, Lizcano, J.M, Deak, M, Alessi, D.R, Van Aalten, D.M.F. | | Deposit date: | 2002-07-23 | | Release date: | 2003-07-17 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | High Resolution Crystal Structure of the Human Pdk1 Catalytic Domain Defines the Regulatory Phosphopeptide Docking Site
Embo J., 21, 2003
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3ZNV
 | | Crystal structure of the OTU domain of OTULIN at 1.3 Angstroms. | | Descriptor: | CALCIUM ION, CHLORIDE ION, GLYCEROL, ... | | Authors: | Keusekotten, K, Elliott, P.R, Glockner, L, Kulathu, Y, Wauer, T, Krappmann, D, Hofmann, K, Komander, D. | | Deposit date: | 2013-02-18 | | Release date: | 2013-06-26 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Otulin Antagonizes Lubac Signaling by Specifically Hydrolyzing met1-Linked Polyubiquitin.
Cell(Cambridge,Mass.), 153, 2013
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5AF5
 | | Structure of Lys33-linked triUb S.G. P 212121 | | Descriptor: | POLYUBIQUITIN-C | | Authors: | Michel, M.A, Elliott, P.R, Swatek, K.N, Simicek, M, Pruneda, J.N, Wagstaff, J.L, Freund, S.M.V, Komander, D. | | Deposit date: | 2015-01-19 | | Release date: | 2015-03-25 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.68 Å) | | Cite: | Assembly and Specific Recognition of K29- and K33-Linked Polyubiquitin.
Mol.Cell, 58, 2015
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5CAW
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7T3X
 | | Structure of unphosphorylated Pediculus humanus (Ph) PINK1 D334A mutant | | Descriptor: | Serine/threonine-protein kinase PINK1 | | Authors: | Gan, Z.Y, Leis, A, Dewson, G, Glukhova, A, Komander, D. | | Deposit date: | 2021-12-09 | | Release date: | 2021-12-22 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.53 Å) | | Cite: | Activation mechanism of PINK1.
Nature, 602, 2022
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7T4M
 | | Structure of dodecameric unphosphorylated Pediculus humanus (Ph) PINK1 D357A mutant | | Descriptor: | Serine/threonine-protein kinase PINK1, putative | | Authors: | Gan, Z.Y, Leis, A, Dewson, G, Glukhova, A, Komander, D. | | Deposit date: | 2021-12-10 | | Release date: | 2022-01-12 | | Last modified: | 2024-02-28 | | Method: | ELECTRON MICROSCOPY (2.48 Å) | | Cite: | Activation mechanism of PINK1.
Nature, 602, 2022
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7T4L
 | | Structure of dimeric phosphorylated Pediculus humanus (Ph) PINK1 with extended alpha-C helix in chain B | | Descriptor: | Serine/threonine-protein kinase PINK1, putative | | Authors: | Gan, Z.Y, Leis, A, Dewson, G, Glukhova, A, Komander, D. | | Deposit date: | 2021-12-10 | | Release date: | 2022-01-12 | | Last modified: | 2022-02-23 | | Method: | ELECTRON MICROSCOPY (3.28 Å) | | Cite: | Activation mechanism of PINK1.
Nature, 602, 2022
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7T4K
 | | Structure of dimeric phosphorylated Pediculus humanus (Ph) PINK1 with kinked alpha-C helix in chain B | | Descriptor: | Serine/threonine-protein kinase PINK1, putative | | Authors: | Gan, Z.Y, Leis, A, Dewson, G, Glukhova, A, Komander, D. | | Deposit date: | 2021-12-10 | | Release date: | 2022-01-12 | | Last modified: | 2022-02-23 | | Method: | ELECTRON MICROSCOPY (3.25 Å) | | Cite: | Activation mechanism of PINK1.
Nature, 602, 2022
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7T4N
 | | Structure of dimeric unphosphorylated Pediculus humanus (Ph) PINK1 D357A mutant | | Descriptor: | Serine/threonine-protein kinase PINK1, putative | | Authors: | Gan, Z.Y, Leis, A, Dewson, G, Glukhova, A, Komander, D. | | Deposit date: | 2021-12-10 | | Release date: | 2022-01-12 | | Last modified: | 2024-02-28 | | Method: | ELECTRON MICROSCOPY (2.35 Å) | | Cite: | Activation mechanism of PINK1.
Nature, 602, 2022
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7TZJ
 | | SARS CoV-2 PLpro in complex with inhibitor 3k | | Descriptor: | DIMETHYL SULFOXIDE, N-[(3-fluorophenyl)methyl]-1-[(1R)-1-naphthalen-1-ylethyl]piperidine-4-carboxamide, Papain-like protease, ... | | Authors: | Calleja, D.J, Klemm, T, Lechtenberg, B.C, Kuchel, N.W, Lessene, G, Komander, D. | | Deposit date: | 2022-02-15 | | Release date: | 2022-03-02 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.66 Å) | | Cite: | Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors.
Front Chem, 10, 2022
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5AAY
 | | TBK1 recruitment to cytosol-invading Salmonella induces anti- bacterial autophagy | | Descriptor: | NF-KAPPA-B ESSENTIAL MODULATOR, ZINC ION | | Authors: | Thurston, T.l, Allen, M.D, Ravenhill, B, Karpiyevitch, M, Bloor, S, Kaul, A, Matthews, S, Komander, D, Holden, D, Bycroft, M, Randow, F. | | Deposit date: | 2015-07-31 | | Release date: | 2016-07-13 | | Last modified: | 2019-10-23 | | Method: | SOLUTION NMR | | Cite: | Recruitment of Tbk1 to Cytosol-Invading Salmonella Induces Wipi2-Dependent Antibacterial Autophagy.
Embo J., 35, 2016
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5AAZ
 | | TBK1 recruitment to cytosol-invading Salmonella induces anti- bacterial autophagy | | Descriptor: | OPTINEURIN, ZINC ION | | Authors: | Thurston, T.l, Allen, M.D, Ravenhill, B, Karpiyevitch, M, Bloor, S, Kaul, A, Matthews, S, Komander, D, Holden, D, Bycroft, M, Randow, F. | | Deposit date: | 2015-07-31 | | Release date: | 2016-07-13 | | Last modified: | 2016-08-31 | | Method: | SOLUTION NMR | | Cite: | Recruitment of Tbk1 to Cytosol-Invading Salmonella Induces Wipi2-Dependent Antibacterial Autophagy.
Embo J., 35, 2016
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5AAQ
 | | TBK1 recruitment to cytosol-invading Salmonella induces anti- bacterial autophagy | | Descriptor: | CALCIUM-BINDING AND COILED-COIL DOMAIN-CONTAINING PROTEIN 2, ZINC ION | | Authors: | Thurston, T.L, Allen, M.D, Ravenhill, B, Karpiyevitch, M, Bloor, S, Kaul, A, Matthews, S, Komander, D, Holden, D, Bycroft, M, Randow, F. | | Deposit date: | 2015-07-28 | | Release date: | 2016-07-13 | | Last modified: | 2019-10-23 | | Method: | SOLUTION NMR | | Cite: | Recruitment of Tbk1 to Cytosol-Invading Salmonella Induces Wipi2-Dependent Antibacterial Autophagy.
Embo J., 35, 2016
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4OYJ
 | | Structure of the apo HOIP PUB domain | | Descriptor: | E3 ubiquitin-protein ligase RNF31, SULFATE ION | | Authors: | Elliott, P.R, Komander, D. | | Deposit date: | 2014-02-12 | | Release date: | 2014-05-21 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Molecular Basis and Regulation of OTULIN-LUBAC Interaction.
Mol.Cell, 54, 2014
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3VVV
 | | Skich domain of NDP52 | | Descriptor: | Calcium-binding and coiled-coil domain-containing protein 2 | | Authors: | Akutsu, M, Muhlinen, N.V, Randow, F, Komander, D. | | Deposit date: | 2012-07-28 | | Release date: | 2013-02-27 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | LC3C, bound selectively by a noncanonical LIR motif in NDP52, is required for antibacterial autophagy
Mol.Cell, 48, 2012
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4OYK
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3VVW
 | | NDP52 in complex with LC3C | | Descriptor: | Calcium-binding and coiled-coil domain-containing protein 2, Microtubule-associated proteins 1A/1B light chain 3C | | Authors: | Akutsu, M, Muhlinen, N.V, Randow, F, Komander, D. | | Deposit date: | 2012-07-28 | | Release date: | 2013-02-27 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | LC3C, bound selectively by a noncanonical LIR motif in NDP52, is required for antibacterial autophagy
Mol.Cell, 48, 2012
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6W9O
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