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Human p53 core domain mutant M133L-V203A-N239Y-G245S-N268D
分子名称:	CALCIUM ION, CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Joerger, A.C, Fersht, A.R.
登録日	2006-08-15
公開日	2006-09-20
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (1.69 Å)
主引用文献	Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs. Proc.Natl.Acad.Sci.USA, 103, 2006

2J1X

Human p53 core domain mutant M133L-V203A-Y220C-N239Y-N268D
分子名称:	CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Joerger, A.C, Fersht, A.R.
登録日	2006-08-15
公開日	2006-09-20
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (1.65 Å)
主引用文献	Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs. Proc.Natl.Acad.Sci.USA, 103, 2006

2J1W

Human p53 core domain mutant M133L-V143A-V203A-N239Y-N268D
分子名称:	CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Joerger, A.C, Fersht, A.R.
登録日	2006-08-15
公開日	2006-09-20
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs. Proc.Natl.Acad.Sci.USA, 103, 2006

2J20

Human p53 core domain mutant M133L-V203A-N239Y-N268D-R273C
分子名称:	CELLULAR TUMOR ANTIGEN P53, SULFATE ION, ZINC ION
著者	Joerger, A.C, Ang, H.C, Fersht, A.R.
登録日	2006-08-15
公開日	2006-09-20
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs. Proc.Natl.Acad.Sci.USA, 103, 2006

2J1Z

Human p53 core domain mutant M133L-V203A-N239Y-N268D-F270L
分子名称:	CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Joerger, A.C, Fersht, A.R.
登録日	2006-08-15
公開日	2006-09-20
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs. Proc.Natl.Acad.Sci.USA, 103, 2006

2J21

Human p53 core domain mutant M133L-V203A-N239Y-N268D-R282W
分子名称:	CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Joerger, A.C, Fersht, A.R.
登録日	2006-08-15
公開日	2006-09-20
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (1.6 Å)
主引用文献	Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs. Proc.Natl.Acad.Sci.USA, 103, 2006

1HL2

Crystal structure of N-acetylneuraminate lyase from E. coli mutant L142R in complex with b-hydroxypyruvate
分子名称:	3-HYDROXYPYRUVIC ACID, N-ACETYLNEURAMINATE LYASE SUBUNIT
著者	Joerger, A.C, Fersht, A.R.
登録日	2003-03-12
公開日	2003-05-09
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Mimicking Natural Evolution in Vitro: An N-Acetylneuraminate Lyase Mutant with an Increased Dihydrodipicolinate Synthase Activity Proc.Natl.Acad.Sci.USA, 100, 2003

2BIN

human p53 core domain mutant M133L-H168R-V203A-N239Y-N268D
分子名称:	CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Joerger, A.C, Fersht, A.R.
登録日	2005-01-25
公開日	2005-01-26
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Structures of P53 Cancer Mutants and Mechanism of Rescue by Second-Site Suppressor Mutations J.Biol.Chem., 280, 2005

2BIP

human p53 core domain mutant M133L-H168R-V203A-N239Y-R249S-N268D
分子名称:	CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Joerger, A.C, Fersht, A.R.
登録日	2005-01-25
公開日	2005-01-26
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Structures of P53 Cancer Mutants and Mechanism of Rescue by Second-Site Suppressor Mutations J.Biol.Chem., 280, 2005

2BIO

human p53 core domain mutant M133L-V203A-N239Y-R249S-N268D
分子名称:	CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Joerger, A.C, Fersht, A.R.
登録日	2005-01-25
公開日	2005-01-26
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Structures of P53 Cancer Mutants and Mechanism of Rescue by Second-Site Suppressor Mutations J.Biol.Chem., 280, 2005

2BIQ

human p53 core domain mutant T123A-M133L-H168R-V203A-N239Y-R249S- N268D
分子名称:	CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Joerger, A.C, Fersht, A.R.
登録日	2005-01-25
公開日	2005-01-26
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Structures of P53 Cancer Mutants and Mechanism of Rescue by Second-Site Suppressor Mutations J.Biol.Chem., 280, 2005

2BIM

human p53 core domain mutant M133L-V203A-N239Y-N268D-R273H
分子名称:	CELLULAR TUMOR ANTIGEN P53, SULFATE ION, ZINC ION
著者	Joerger, A.C, Fersht, A.R.
登録日	2005-01-25
公開日	2005-01-26
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (1.98 Å)
主引用文献	Structures of P53 Cancer Mutants and Mechanism of Rescue by Second-Site Suppressor Mutations J.Biol.Chem., 280, 2005

5AB9

Structure of the p53 cancer mutant Y220C with bound small molecule 7- ethyl-3-(piperidin-4-yl)-1H-indole
分子名称:	7-ethyl-3-(piperidin-4-yl)-1H-indole, CELLULAR TUMOR ANTIGEN P53, DI(HYDROXYETHYL)ETHER, ...
著者	Joerger, A.C.
登録日	2015-08-04
公開日	2015-12-16
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.36 Å)
主引用文献	Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant P53. Structure, 23, 2015

5ABA

Structure of the p53 cancer mutant Y220C with bound small-molecule stabilizer PhiKan5149
分子名称:	1-{1-[(3-bromo-5-chloro-2-hydroxyphenyl)methyl piperidin-4-yl}piperidin-4-ol], CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Joerger, A.C.
登録日	2015-08-04
公開日	2015-12-16
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.62 Å)
主引用文献	Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant P53. Structure, 23, 2015

1UOL

Crystal structure of the human p53 core domain mutant M133L/V203A/N239Y/N268D at 1.9 A resolution.
分子名称:	CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Joerger, A.C, Allen, M.D, Fersht, A.R.
登録日	2003-09-19
公開日	2003-10-16
最終更新日	2011-07-13
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Crystal Structure of a Superstable Mutant of Human P53 Core Domain. Insights Into the Mechanism of Rescuing Oncogenic Mutations J.Biol.Chem., 279, 2004

5AOL

Structure of the p53 cancer mutant Y220C with bound 3-bromo-5-(trifluoromethyl)benzene-1,2-diamine
分子名称:	3-BROMO-5-(TRIFLUOROMETHYL)BENZENE-1,2-DIAMINE, CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Joerger, A.C, Harbrecht, H.
登録日	2015-09-10
公開日	2015-12-16
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.5 Å)
主引用文献	Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant P53. Structure, 23, 2015

5AOM

Structure of the p53 cancer mutant Y220C with bound small molecule PhiKan883
分子名称:	CELLULAR TUMOR ANTIGEN P53, GLYCEROL, N-(5-chloranyl-2-oxidanyl-phenyl)piperidine-4-carboxamide, ...
著者	Joerger, A.C, Boeckler, F.M, Wilcken, R.
登録日	2015-09-10
公開日	2015-12-16
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.74 Å)
主引用文献	Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant P53. Structure, 23, 2015

5AOJ

Structure of the p53 cancer mutant Y220C in complex with 2-hydroxy-3, 5-diiodo-4-(1H-pyrrol-1-yl)benzoic acid
分子名称:	2-hydroxy-3,5-diiodo-4-(1H-pyrrol-1-yl)benzoic acid, CELLULAR TUMOR ANTIGEN P53, DI(HYDROXYETHYL)ETHER, ...
著者	Joerger, A.C, Baud, M.G, Bauer, M.R, Fersht, A.R.
登録日	2015-09-10
公開日	2015-12-16
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.47 Å)
主引用文献	Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant P53. Structure, 23, 2015

5AOK

Structure of the p53 cancer mutant Y220C with bound small molecule PhiKan7099
分子名称:	5-[2-cyclopropyl-5-(1H-pyrrol-1-yl)-1,3-oxazol-4-yl]-1H-1,2,3,4-tetrazole, CELLULAR TUMOR ANTIGEN P53, DI(HYDROXYETHYL)ETHER, ...
著者	Joerger, A.C.
登録日	2015-09-10
公開日	2015-12-16
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.35 Å)
主引用文献	Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant P53. Structure, 23, 2015

5AOI

Structure of the p53 cancer mutant Y220C in complex with an indole- based small molecule
分子名称:	2-(5-BROMO-7-ETHYL-2-METHYL-1H-INDOLE-3-YL)ETHAN-1-AMIN, CELLULAR TUMOR ANTIGEN P53, DI(HYDROXYETHYL)ETHER, ...
著者	Joerger, A.C, Wilcken, R.
登録日	2015-09-10
公開日	2015-12-16
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.78 Å)
主引用文献	Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant P53. Structure, 23, 2015

2WQJ

Crystal structure of a truncated variant of the human p73 tetramerization domain
分子名称:	TUMOR PROTEIN P73
著者	Joerger, A.C.
登録日	2009-08-21
公開日	2009-10-06
最終更新日	2019-05-08
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Structural Evolution of P53, P63, and P73: Implication for Heterotetramer Formation. Proc.Natl.Acad.Sci.USA, 106, 2009

2WQI

Crystal structure of the human p73 tetramerization domain
分子名称:	TUMOR PROTEIN P73
著者	Joerger, A.C.
登録日	2009-08-21
公開日	2009-10-06
最終更新日	2019-05-08
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	Structural Evolution of P53, P63, and P73: Implication for Heterotetramer Formation. Proc.Natl.Acad.Sci.USA, 106, 2009

2WTT

Structure of the human p73 tetramerization domain (crystal form II)
分子名称:	TUMOR PROTEIN P73
著者	Joerger, A.C.
登録日	2009-09-21
公開日	2009-10-13
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Structural Evolution of P53, P63, and P73: Implication for Heterotetramer Formation. Proc.Natl.Acad.Sci.USA, 106, 2009

1E4A

L-Fuculose 1-Phosphate Aldolase from Escherichia coli Mutant Del(27)
分子名称:	BETA-MERCAPTOETHANOL, L-FUCULOSE 1-PHOSPHATE ALDOLASE, SULFATE ION, ...
著者	Joerger, A.C, Schulz, G.E.
登録日	2000-06-30
公開日	2000-11-06
最終更新日	2019-01-30
実験手法	X-RAY DIFFRACTION (2.15 Å)
主引用文献	Structures of L-Fuculose-1-Phosphate Aldolase Mutants Outlining Motions During Catalysis J.Mol.Biol., 303, 2000

1E47

L-Fuculose 1-Phosphate Aldolase from Escherichia coli Mutant E73Q
分子名称:	1,3-DIHYDROXYACETONEPHOSPHATE, BETA-MERCAPTOETHANOL, L-FUCULOSE 1-PHOSPHATE ALDOLASE, ...
著者	Joerger, A.C, Schulz, G.E.
登録日	2000-06-30
公開日	2000-11-06
最終更新日	2019-01-30
実験手法	X-RAY DIFFRACTION (2.15 Å)
主引用文献	Structures of l-fuculose-1-phosphate aldolase mutants outlining motions during catalysis. J. Mol. Biol., 303, 2000

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