4TU7
| Structure of U2AF65 D231V variant with BrU5 DNA | Descriptor: | 1,4-DIETHYLENE DIOXIDE, DNA (5'-D(*UP*UP*UP*UP*(BRU)P*UP*U)-3'), GLYCEROL, ... | Authors: | Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L. | Deposit date: | 2014-06-24 | Release date: | 2014-11-26 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.087 Å) | Cite: | Structure-guided U2AF65 variant improves recognition and splicing of a defective pre-mRNA. Proc.Natl.Acad.Sci.USA, 111, 2014
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5EV1
| Structure I of Intact U2AF65 Recognizing a 3' Splice Site Signal | Descriptor: | DI(HYDROXYETHYL)ETHER, DNA/RNA (5'-R(*UP*UP*U)-D(P*UP*UP*(BRU)P*U)-R(P*UP*U)-3'), SODIUM ION, ... | Authors: | Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L. | Deposit date: | 2015-11-19 | Release date: | 2016-02-24 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.037 Å) | Cite: | An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal. Nat Commun, 7, 2016
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5EV2
| Structure II of Intact U2AF65 Recognizing the 3' Splice Site Signal | Descriptor: | 1,4-DIETHYLENE DIOXIDE, DI(HYDROXYETHYL)ETHER, DNA (5'-R(P*UP*U)-D(P*UP*U)-R(P*U)-D(P*UP*(BRU)P*U)-3'), ... | Authors: | Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L. | Deposit date: | 2015-11-19 | Release date: | 2016-02-24 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal. Nat Commun, 7, 2016
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5EV3
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5EV4
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8FB3
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6XH1
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6XLW
| Crystal structure of U2AF65 bound to AdML splice site sequence | Descriptor: | DI(HYDROXYETHYL)ETHER, DNA/RNA (5'-R(P*UP*UP*(UD)P*UP*U)-D(P*(BRU))-R(P*CP*C)-3'), GLYCEROL, ... | Authors: | Maji, D, Jenkins, J.L, Kielkopf, C.L. | Deposit date: | 2020-06-29 | Release date: | 2020-10-07 | Last modified: | 2022-03-16 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing. J.Biol.Chem., 295, 2020
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6XH0
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6XH3
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6XH2
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6XLX
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6XLV
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6XKN
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6XKO
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4G6R
| Minimal Hairpin Ribozyme in the Transition State with G8I Variation | Descriptor: | Loop A Ribozyme strand, Loop A Substrate strand, Loop B Ribozyme Strand, ... | Authors: | Liberman, J.A, Jenkins, J.L, Krucinska, J, Wedekind, J.E. | Deposit date: | 2012-07-19 | Release date: | 2012-08-15 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.832 Å) | Cite: | A Transition-State Interaction Shifts Nucleobase Ionization toward Neutrality To Facilitate Small Ribozyme Catalysis. J.Am.Chem.Soc., 134, 2012
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4G6P
| Minimal Hairpin Ribozyme in the Precatalytic State with A38P Variation | Descriptor: | COBALT HEXAMMINE(III), Loop A Substrate strand, Loop A and Loop B Ribozyme strand, ... | Authors: | Liberman, J.A, Jenkins, J.L, Krucinska, J, Wedekind, J.E. | Deposit date: | 2012-07-19 | Release date: | 2012-08-15 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.641 Å) | Cite: | A Transition-State Interaction Shifts Nucleobase Ionization toward Neutrality To Facilitate Small Ribozyme Catalysis. J.Am.Chem.Soc., 134, 2012
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4G6S
| Minimal Hairpin Ribozyme in the Transition State with A38P Variation | Descriptor: | COBALT HEXAMMINE(III), Loop A Substrate strand, Loop A and Loop B Ribozyme strand, ... | Authors: | Liberman, J.A, Jenkins, J.L, Krucinska, J, Wedekind, J.E. | Deposit date: | 2012-07-19 | Release date: | 2012-08-08 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.84 Å) | Cite: | A Transition-State Interaction Shifts Nucleobase Ionization toward Neutrality To Facilitate Small Ribozyme Catalysis. J.Am.Chem.Soc., 134, 2012
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6N3D
| Structure of HIV Tat-specific factor 1 U2AF Homology Motif (APO-State) | Descriptor: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | Authors: | Loerch, S, Jenkins, J.L, Kielkopf, C.L. | Deposit date: | 2018-11-15 | Release date: | 2019-01-02 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.13 Å) | Cite: | The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface. J. Biol. Chem., 294, 2019
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6N3F
| Structure of HIV Tat-specific factor 1 U2AF Homology Motif bound to SF3b1 ULM5 | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, HIV Tat-specific factor 1, ... | Authors: | Leach, J.R, Jenkins, J.L, Kielkopf, C.L. | Deposit date: | 2018-11-15 | Release date: | 2019-01-02 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.099 Å) | Cite: | The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface. J. Biol. Chem., 294, 2019
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6N3E
| Structure of HIV Tat-specific factor 1 U2AF Homology Motif bound to U2AF ligand motif 4 | Descriptor: | FORMIC ACID, GLYCEROL, HIV Tat-specific factor 1, ... | Authors: | Loerch, S, Jenkins, J.L, Kielkopf, C.L. | Deposit date: | 2018-11-15 | Release date: | 2019-01-02 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.893 Å) | Cite: | The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface. J. Biol. Chem., 294, 2019
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2AY0
| Structure of the Lys9Met mutant of the E. coli Proline Utilization A (PutA) DNA-binding domain. | Descriptor: | Bifunctional putA protein, CHLORIDE ION | Authors: | Larson, J.D, Schuermann, J.P, Zhou, Y, Jenkins, J.L, Becker, D.F, Tanner, J.J. | Deposit date: | 2005-09-06 | Release date: | 2006-08-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structures of the DNA-binding domain of Escherichia coli proline utilization A flavoprotein and analysis of the role of Lys9 in DNA recognition. Protein Sci., 15, 2006
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7SN6
| U2AF65 UHM BOUND TO SF3B155 ULM5 | Descriptor: | ISOPROPYL ALCOHOL, Splicing factor 3B subunit 1, Splicing factor U2AF 65 kDa subunit | Authors: | Loerch, S, Jenkins, J.L, Kielkopf, C.L. | Deposit date: | 2021-10-27 | Release date: | 2022-07-27 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A UHM-ULM interface with unusual structural features contributes to U2AF2 and SF3B1 association for pre-mRNA splicing. J.Biol.Chem., 298, 2022
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7S3C
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8FZA
| Class I type III preQ1 riboswitch from E. coli | Descriptor: | 7-DEAZA-7-AMINOMETHYL-GUANINE, MANGANESE (II) ION, PreQ1 Riboswitch (30-MER) | Authors: | Wedekind, J.E, Schroeder, G.M, Jenkins, J.L. | Deposit date: | 2023-01-27 | Release date: | 2023-08-30 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure and function analysis of a type III preQ 1 -I riboswitch from Escherichia coli reveals direct metabolite sensing by the Shine-Dalgarno sequence. J.Biol.Chem., 299, 2023
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