6AEL
| Crystal structure of ENPP1 in complex with 3'3'-cGAMP | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, ... | Authors: | Kato, K, Nishimasu, H, Hirano, S, Hirano, H, Ishitani, R, Nureki, O. | Deposit date: | 2018-08-05 | Release date: | 2019-03-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1. Nat Commun, 9, 2018
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4OO8
| Crystal structure of Streptococcus pyogenes Cas9 in complex with guide RNA and target DNA | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, DNA (5'-D(*CP*CP*AP*GP*CP*CP*AP*AP*GP*CP*GP*CP*AP*CP*CP*TP*AP*AP*TP*TP*TP*CP*C)-3'), RNA (97-MER) | Authors: | Nishimasu, H, Ishitani, R, Nureki, O. | Deposit date: | 2014-01-31 | Release date: | 2014-02-26 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of Cas9 in complex with guide RNA and target DNA Cell(Cambridge,Mass.), 156, 2014
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4MKP
| Crystal structure of human cGAS apo form | Descriptor: | Cyclic GMP-AMP synthase, ZINC ION | Authors: | Kato, K, Ishii, R, Ishitani, R, Nureki, O. | Deposit date: | 2013-09-05 | Release date: | 2013-10-30 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.953 Å) | Cite: | Structural and Functional Analyses of DNA-Sensing and Immune Activation by Human cGAS Plos One, 8, 2013
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4P79
| Crystal structure of mouse claudin-15 | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Claudin-15 | Authors: | Suzuki, H, Nishizawa, T, Tani, K, Yamazaki, Y, Tamura, A, Ishitani, R, Dohmae, N, Tsukita, S, Nureki, O, Fujiyoshi, Y. | Deposit date: | 2014-03-26 | Release date: | 2014-04-30 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of a claudin provides insight into the architecture of tight junctions. Science, 344, 2014
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3G5S
| Crystal structure of Thermus thermophilus TrmFO in complex with glutathione | Descriptor: | 1,2-ETHANEDIOL, FLAVIN-ADENINE DINUCLEOTIDE, GLUTATHIONE, ... | Authors: | Nishimasu, H, Ishitani, R, Hori, H, Nureki, O. | Deposit date: | 2009-02-05 | Release date: | 2009-05-19 | Last modified: | 2011-12-14 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Atomic structure of a folate/FAD-dependent tRNA T54 methyltransferase Proc.Natl.Acad.Sci.USA, 106, 2009
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3G5Q
| Crystal structure of Thermus thermophilus TrmFO | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, FLAVIN-ADENINE DINUCLEOTIDE, Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase trmFO | Authors: | Nishimasu, H, Ishitani, R, Hori, H, Nureki, O. | Deposit date: | 2009-02-05 | Release date: | 2009-05-19 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.102 Å) | Cite: | Atomic structure of a folate/FAD-dependent tRNA T54 methyltransferase Proc.Natl.Acad.Sci.USA, 106, 2009
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3G5R
| Crystal structure of Thermus thermophilus TrmFO in complex with tetrahydrofolate | Descriptor: | (6S)-5,6,7,8-TETRAHYDROFOLATE, 1,2-ETHANEDIOL, CALCIUM ION, ... | Authors: | Nishimasu, H, Ishitani, R, Hori, H, Nureki, O. | Deposit date: | 2009-02-05 | Release date: | 2009-05-19 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Atomic structure of a folate/FAD-dependent tRNA T54 methyltransferase Proc.Natl.Acad.Sci.USA, 106, 2009
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5HRT
| Crystal structure of mouse autotaxin in complex with a DNA aptamer | Descriptor: | CALCIUM ION, CHLORIDE ION, Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, ... | Authors: | Kato, K, Nishimasu, H, Morita, J, Ishitani, R, Nureki, O. | Deposit date: | 2016-01-24 | Release date: | 2016-04-06 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.997 Å) | Cite: | Structural basis for specific inhibition of Autotaxin by a DNA aptamer Nat.Struct.Mol.Biol., 23, 2016
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4XJ6
| Crystal structure of Escherichia coli DncV 3'-deoxy GTP bound form | Descriptor: | 3'-DEOXY-GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, VC0179-like protein | Authors: | Kato, K, Ishii, R, Ishitani, R, Nureki, O. | Deposit date: | 2015-01-08 | Release date: | 2015-04-29 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Structural Basis for the Catalytic Mechanism of DncV, Bacterial Homolog of Cyclic GMP-AMP Synthase Structure, 23, 2015
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4XJ3
| Crystal structure of Vibrio cholerae DncV GTP bound form | Descriptor: | 1,2-ETHANEDIOL, Cyclic AMP-GMP synthase, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Kato, K, Ishii, R, Ishitani, R, Nureki, O. | Deposit date: | 2015-01-08 | Release date: | 2015-04-29 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structural Basis for the Catalytic Mechanism of DncV, Bacterial Homolog of Cyclic GMP-AMP Synthase Structure, 23, 2015
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4XJ1
| Crystal structure of Vibrio cholerae DncV apo form | Descriptor: | 1,2-ETHANEDIOL, Cyclic AMP-GMP synthase | Authors: | Kato, K, Ishii, R, Ishitani, R, Nureki, O. | Deposit date: | 2015-01-08 | Release date: | 2015-04-29 | Last modified: | 2020-02-05 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Structural Basis for the Catalytic Mechanism of DncV, Bacterial Homolog of Cyclic GMP-AMP Synthase Structure, 23, 2015
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4XJ4
| Crystal structure of Vibrio cholerae DncV 3'-deoxy ATP bound form | Descriptor: | 1,2-ETHANEDIOL, 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, Cyclic AMP-GMP synthase, ... | Authors: | Kato, K, Ishii, R, Ishitani, R, Nureki, O. | Deposit date: | 2015-01-08 | Release date: | 2015-04-29 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.596 Å) | Cite: | Structural Basis for the Catalytic Mechanism of DncV, Bacterial Homolog of Cyclic GMP-AMP Synthase Structure, 23, 2015
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4XJ5
| Crystal structure of Vibrio cholerae DncV 3'-deoxy GTP bound form | Descriptor: | 1,2-ETHANEDIOL, 3'-DEOXY-GUANOSINE-5'-TRIPHOSPHATE, Cyclic AMP-GMP synthase, ... | Authors: | Kato, K, Ishii, R, Ishitani, R, Nureki, O. | Deposit date: | 2015-01-08 | Release date: | 2015-04-29 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.552 Å) | Cite: | Structural Basis for the Catalytic Mechanism of DncV, Bacterial Homolog of Cyclic GMP-AMP Synthase Structure, 23, 2015
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5JYJ
| Crystal structure of mouse JUNO | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Sperm-egg fusion protein Juno | Authors: | Kato, K, Nishimasu, H, Morita, J, Ishitani, R, Nureki, O. | Deposit date: | 2016-05-14 | Release date: | 2017-05-24 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of the egg IZUMO1 receptor JUNO To Be Published
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4L3O
| Crystal Structure of SIRT2 in complex with the macrocyclic peptide S2iL5 | Descriptor: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, NAD-dependent protein deacetylase sirtuin-2, ... | Authors: | Yamagata, K, Nishimasu, H, Ishitani, R, Nureki, O. | Deposit date: | 2013-06-06 | Release date: | 2014-02-19 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.518 Å) | Cite: | Structural Basis for Potent Inhibition of SIRT2 Deacetylase by a Macrocyclic Peptide Inducing Dynamic Structural Change Structure, 22, 2013
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5GVS
| Crystal structure of the DDX41 DEAD domain in an apo open form | Descriptor: | Probable ATP-dependent RNA helicase DDX41 | Authors: | Omura, H, Oikawa, D, Nakane, T, Kato, M, Ishii, R, Goto, Y, Suga, H, Ishitani, R, Tokunaga, F, Nureki, O. | Deposit date: | 2016-09-06 | Release date: | 2016-10-19 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural and Functional Analysis of DDX41: a bispecific immune receptor for DNA and cyclic dinucleotide Sci Rep, 6, 2016
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5GVR
| Crystal structure of the DDX41 DEAD domain in an apo closed form | Descriptor: | (2S)-2-hydroxybutanedioic acid, Probable ATP-dependent RNA helicase DDX41 | Authors: | Omura, H, Oikawa, D, Nakane, T, Kato, M, Ishii, R, Goto, Y, Suga, H, Ishitani, R, Tokunaga, F, Nureki, O. | Deposit date: | 2016-09-06 | Release date: | 2016-10-19 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural and Functional Analysis of DDX41: a bispecific immune receptor for DNA and cyclic dinucleotide Sci Rep, 6, 2016
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1UDZ
| Isoleucyl-tRNA synthetase editing domain | Descriptor: | Isoleucyl-tRNA synthetase | Authors: | Fukunaga, R, Fukai, S, Ishitani, R, Nureki, O, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2003-05-08 | Release date: | 2004-03-23 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structures of the CP1 domain from Thermus thermophilus isoleucyl-tRNA synthetase and its complex with L-valine. J.Biol.Chem., 279, 2004
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1UE0
| Isoleucyl-tRNA synthetase editing domain complexed with L-Valine | Descriptor: | Isoleucyl-tRNA synthetase, VALINE | Authors: | Fukunaga, R, Fukai, S, Ishitani, R, Nureki, O, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2003-05-08 | Release date: | 2004-03-23 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structures of the CP1 domain from Thermus thermophilus isoleucyl-tRNA synthetase and its complex with L-valine. J.Biol.Chem., 279, 2004
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3OQI
| Crystal structure of B. licheniformis CDPS yvmC-BLIC in complex with CHES | Descriptor: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, GLYCEROL, Putative uncharacterized protein yvmC | Authors: | Bonnefond, L, Arai, T, Suzuki, T, Ishitani, R, Nureki, O. | Deposit date: | 2010-09-03 | Release date: | 2011-02-23 | Last modified: | 2017-11-08 | Method: | X-RAY DIFFRACTION (1.701 Å) | Cite: | Structural basis for nonribosomal peptide synthesis by an aminoacyl-tRNA synthetase paralog. Proc.Natl.Acad.Sci.USA, 108, 2011
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3OQH
| Crystal structure of B. licheniformis CDPS yvmC-BLIC | Descriptor: | GLYCEROL, Putative uncharacterized protein yvmC | Authors: | Bonnefond, L, Arai, T, Suzuki, T, Ishitani, R, Nureki, O. | Deposit date: | 2010-09-03 | Release date: | 2011-02-23 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.901 Å) | Cite: | Structural basis for nonribosomal peptide synthesis by an aminoacyl-tRNA synthetase paralog. Proc.Natl.Acad.Sci.USA, 108, 2011
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3S7T
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4N0H
| Crystal structure of S. cerevisiae mitochondrial GatFAB | Descriptor: | Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial, Glutamyl-tRNA(Gln) amidotransferase subunit B, ... | Authors: | Araiso, Y, Ishitani, R, Nureki, O. | Deposit date: | 2013-10-02 | Release date: | 2014-04-16 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.952 Å) | Cite: | Crystal structure of Saccharomyces cerevisiae mitochondrial GatFAB reveals a novel subunit assembly in tRNA-dependent amidotransferases Nucleic Acids Res., 42, 2014
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4N0I
| Crystal structure of S. cerevisiae mitochondrial GatFAB in complex with glutamine | Descriptor: | GLUTAMINE, Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial, ... | Authors: | Araiso, Y, Ishitani, R, Nureki, O. | Deposit date: | 2013-10-02 | Release date: | 2014-04-16 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.001 Å) | Cite: | Crystal structure of Saccharomyces cerevisiae mitochondrial GatFAB reveals a novel subunit assembly in tRNA-dependent amidotransferases Nucleic Acids Res., 42, 2014
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4KPP
| Crystal Structure of H+/Ca2+ Exchanger CAX | Descriptor: | (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CALCIUM ION, OLEIC ACID, ... | Authors: | Nishizawa, T, Ishitani, R, Nureki, O. | Deposit date: | 2013-05-14 | Release date: | 2013-06-26 | Last modified: | 2022-08-24 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for the counter-transport mechanism of a H+/Ca2+ exchanger. Science, 341, 2013
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