4OT9
| crystal structure of the C-terminal domain of p100/NF-kB2 | Descriptor: | Nuclear factor NF-kappa-B p100 subunit, SULFATE ION | Authors: | Tao, Z.H, Huang, D.B, Fusco, A, Gupta, K, Ware, C.F, Duynne, G.V. | Deposit date: | 2014-02-13 | Release date: | 2015-01-14 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.35 Å) | Cite: | p100/I kappa B delta sequesters and inhibits NF-kappa B through kappaBsome formation. Proc.Natl.Acad.Sci.USA, 111, 2014
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1K3Z
| X-ray crystal structure of the IkBb/NF-kB p65 homodimer complex | Descriptor: | Transcription factor p65, transcription factor inhibitor I-kappa-B-beta | Authors: | Shiva, M, Huang, D.B, Chen, Y, Huxford, T, Ghosh, S, Ghosh, G. | Deposit date: | 2001-10-04 | Release date: | 2002-10-04 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | X-ray crystal structure of an IkappaBbeta x NF-kappaB p65 homodimer complex. J.Biol.Chem., 278, 2003
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1LE5
| Crystal structure of a NF-kB heterodimer bound to an IFNb-kB | Descriptor: | 5'-D(*AP*AP*GP*GP*AP*AP*TP*TP*TP*CP*CP*C)-3', 5'-D(*TP*GP*GP*GP*AP*AP*AP*TP*TP*CP*CP*T)-3', Nuclear factor NF-kappa-B p50 subunit, ... | Authors: | Berkowitz, B, Huang, D.B, Chen-Park, F.E, Sigler, P.B, Ghosh, G. | Deposit date: | 2002-04-09 | Release date: | 2003-04-15 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | The X-ray crystal structure of the
NF-kB p50/p65 heterodimer bound
to the Interferon beta-kB site J.Biol.Chem., 277, 2002
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1LEI
| The kB DNA sequence from the HLV-LTR functions as an allosteric regulator of HIV transcription | Descriptor: | 5'-D(*CP*TP*CP*AP*GP*GP*GP*AP*AP*AP*GP*TP*AP*CP*AP*GP*A)-3', 5'-D(*TP*CP*TP*GP*5ITP*AP*CP*5ITP*5ITP*5ITP*CP*CP*CP*TP*GP*AP*G)-3', NUCLEAR FACTOR NF-KAPPA-B P50 SUBUNIT, ... | Authors: | Chen-Park, F, Huang, D.B, Ghosh, G. | Deposit date: | 2002-04-09 | Release date: | 2003-04-15 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The kB DNA sequence from the HIV Long Terminal Repeat functions as an allosteric regulator of HIV transcription J.Biol.Chem., 277, 2002
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1LE9
| Crystal structure of a NF-kB heterodimer bound to the Ig/HIV-kB siti | Descriptor: | 5'-D(*AP*AP*GP*GP*AP*AP*AP*GP*TP*CP*CP*C)-3', 5'-D(*TP*GP*GP*GP*AP*CP*TP*TP*TP*CP*CP*T)-3', NUCLEAR FACTOR NF-KAPPA-B P50 SUBUNIT, ... | Authors: | Benjamin, B, Huang, D.B, Chen-Park, F.E, Sigler, P.B, Ghosh, G. | Deposit date: | 2002-04-09 | Release date: | 2003-04-15 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The x-ray crystal structure of the NF-kappa B p50.p65 heterodimer bound to the interferon beta -kappa B site. J.Biol.Chem., 277, 2002
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1LVE
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5U01
| Cooperative DNA binding by two RelA dimers | Descriptor: | DNA (27-MER), Transcription factor p65 | Authors: | Ghosh, G, Huang, D. | Deposit date: | 2016-11-22 | Release date: | 2017-09-27 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | DNA-binding affinity and transcriptional activity of the RelA homodimer of nuclear factor kappa B are not correlated. J. Biol. Chem., 292, 2017
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5TQX
| CryoEM reconstruction of human IKK1, intermediate conformation 2 | Descriptor: | Inhibitor of nuclear factor kappa-B kinase subunit alpha | Authors: | Lyumkis, D, Ghosh, G, Polley, S, Biswath, T, Huang, D, Passos, D.O. | Deposit date: | 2016-10-24 | Release date: | 2016-11-09 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (5.4 Å) | Cite: | Structural Basis for the Activation of IKK1/ alpha. Cell Rep, 17, 2016
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5TQW
| CryoEM reconstruction of human IKK1, open conformation 1 | Descriptor: | Inhibitor of nuclear factor kappa-B kinase subunit alpha | Authors: | Lyumkis, D, Ghosh, G, Polley, S, Biswath, T, Huang, D, Passos, D.O. | Deposit date: | 2016-10-24 | Release date: | 2016-11-09 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (5.6 Å) | Cite: | Structural Basis for the Activation of IKK1/ alpha. Cell Rep, 17, 2016
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5TQY
| CryoEM reconstruction of human IKK1, closed conformation 3 | Descriptor: | Inhibitor of nuclear factor kappa-B kinase subunit alpha | Authors: | Lyumkis, D, Ghosh, G, Polley, S, Biswath, T, Huang, D, Passos, D.O. | Deposit date: | 2016-10-24 | Release date: | 2016-11-09 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (5.2 Å) | Cite: | Structural Basis for the Activation of IKK1/ alpha. Cell Rep, 17, 2016
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5EBZ
| Crystal structure of human IKK1 | Descriptor: | 2,3-di-O-sulfo-alpha-D-glucopyranose-(1-6)-alpha-D-glucopyranose-(1-6)-2,4-di-O-sulfo-alpha-D-glucopyranose, 2-azanyl-5-phenyl-3-(4-sulfamoylphenyl)benzamide, Inhibitor of nuclear factor kappa-B kinase subunit alpha, ... | Authors: | Polley, S, Passos, D, Huang, D, Biswas, T, Verma, I, Lyumkis, D, Ghosh, G. | Deposit date: | 2015-10-20 | Release date: | 2016-11-02 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (4.5 Å) | Cite: | Structural Basis for the Activation of IKK1/ alpha. Cell Rep, 17, 2016
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1IKN
| IKAPPABALPHA/NF-KAPPAB COMPLEX | Descriptor: | PROTEIN (I-KAPPA-B-ALPHA), PROTEIN (NF-KAPPA-B P50D SUBUNIT), PROTEIN (NF-KAPPA-B P65 SUBUNIT) | Authors: | Huxford, T, Huang, D.-B, Malek, S, Ghosh, G. | Deposit date: | 1998-11-13 | Release date: | 1999-04-12 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation. Cell(Cambridge,Mass.), 95, 1998
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5LVE
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2LVE
| RECOMBINANT LEN | Descriptor: | RLEN | Authors: | Schiffer, M, Pokkuluri, P.R. | Deposit date: | 1998-05-13 | Release date: | 1999-05-18 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | A domain flip as a result of a single amino-acid substitution. Structure, 6, 1998
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4LVE
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3LVE
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