7DGU
| De novo designed protein H4A1R | Descriptor: | de novo designed protein H4A1R | Authors: | Xu, Y, Liao, S, Chen, Q, Liu, H. | Deposit date: | 2020-11-12 | Release date: | 2021-11-24 | Last modified: | 2022-03-02 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | A backbone-centred energy function of neural networks for protein design. Nature, 602, 2022
|
|
7DGW
| De novo designed protein H4A2S | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, de novo designed protein H4A2S | Authors: | Xu, Y, Liao, S, Chen, Q, Liu, H. | Deposit date: | 2020-11-12 | Release date: | 2021-11-24 | Last modified: | 2022-03-02 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | A backbone-centred energy function of neural networks for protein design. Nature, 602, 2022
|
|
7DKO
| De novo design protein AM2M | Descriptor: | de novo designed protein AM2M | Authors: | Bin, H. | Deposit date: | 2020-11-25 | Release date: | 2021-12-08 | Last modified: | 2022-03-02 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | A backbone-centred energy function of neural networks for protein design. Nature, 602, 2022
|
|
7DMF
| |
7DKK
| De novo design protein XM2H | Descriptor: | De novo design protein XM2H | Authors: | Bin, H. | Deposit date: | 2020-11-24 | Release date: | 2021-12-08 | Last modified: | 2022-03-02 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A backbone-centred energy function of neural networks for protein design. Nature, 602, 2022
|
|
7DGY
| De novo designed protein H4C2R | Descriptor: | de novo designed protein H4C2R | Authors: | Xu, Y, Liao, S, Chen, Q, Liu, H. | Deposit date: | 2020-11-12 | Release date: | 2021-12-15 | Last modified: | 2022-03-02 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A backbone-centred energy function of neural networks for protein design. Nature, 602, 2022
|
|
3ENS
| |
8HME
| head module state 1 of Tetrahymena IFT-A | Descriptor: | Intraflagellar transport protein 122 homolog, Intraflagellar transporter, WD40 repeat protein, ... | Authors: | Ma, Y, Wu, J, Lei, M. | Deposit date: | 2022-12-03 | Release date: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural insight into the intraflagellar transport complex IFT-A and its assembly in the anterograde IFT train. Nat Commun, 14, 2023
|
|
8HMF
| head module state 2 of Tetrahymena IFT-A | Descriptor: | Intraflagellar transport protein 122 homolog, Intraflagellar transporter, WD40 repeat protein, ... | Authors: | Ma, Y, Wu, J, Lei, M. | Deposit date: | 2022-12-03 | Release date: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Structural insight into the intraflagellar transport complex IFT-A and its assembly in the anterograde IFT train. Nat Commun, 14, 2023
|
|
8HMD
| base module state 2 of Tetrahymena IFT-A | Descriptor: | Intraflagellar transport protein 122 homolog, Intraflagellar transport protein 43 homolog, Tetratricopeptide repeat protein, ... | Authors: | Ma, Y, Wu, J, Lei, M. | Deposit date: | 2022-12-03 | Release date: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Structural insight into the intraflagellar transport complex IFT-A and its assembly in the anterograde IFT train. Nat Commun, 14, 2023
|
|
8HMC
| base module state 1 of Tetrahymena IFT-A | Descriptor: | Intraflagellar transport protein 122 homolog, Intraflagellar transport protein 43 homolog, Tetratricopeptide repeat protein, ... | Authors: | Ma, Y, Wu, J, Lei, M. | Deposit date: | 2022-12-03 | Release date: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural insight into the intraflagellar transport complex IFT-A and its assembly in the anterograde IFT train. Nat Commun, 14, 2023
|
|
7C7P
| Crystal structure of the SARS-CoV-2 main protease in complex with Telaprevir | Descriptor: | (1S,3aR,6aS)-2-[(2S)-2-({(2S)-2-cyclohexyl-2-[(pyrazin-2-ylcarbonyl)amino]acetyl}amino)-3,3-dimethylbutanoyl]-N-[(2R,3S)-1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-yl]octahydrocyclopenta[c]pyrrole-1-carboxamide, 3C-like proteinase, CHLORIDE ION | Authors: | Zeng, R, Qiao, J.X, Wang, Y.F, Li, Y.S, Yao, R, Yang, S.Y, Lei, J. | Deposit date: | 2020-05-26 | Release date: | 2020-07-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | SARS-CoV-2 M pro inhibitors with antiviral activity in a transgenic mouse model. Science, 371, 2021
|
|
7COM
| Crystal structure of the SARS-CoV-2 main protease in complex with Boceprevir (space group P212121) | Descriptor: | 3C-like proteinase, boceprevir (bound form) | Authors: | Zeng, R, Qiao, J.X, Wang, Y.F, Li, Y.S, Yao, R, Liu, J.M, Zhou, Y.L, Chen, P, Yang, S.Y, Lei, J. | Deposit date: | 2020-08-04 | Release date: | 2020-08-19 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | SARS-CoV-2 M pro inhibitors with antiviral activity in a transgenic mouse model. Science, 371, 2021
|
|
7D3I
| Crystal structure of SARS-CoV-2 main protease in complex with MI-23 | Descriptor: | (3~{S},3~{a}~{S},6~{a}~{R})-2-[3-[3,5-bis(fluoranyl)phenyl]propanoyl]-~{N}-[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]-3,3~{a},4,5,6,6~{a}-hexahydro-1~{H}-cyclopenta[c]pyrrole-3-carboxamide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3C-like proteinase | Authors: | Zeng, R, Li, Y.S, Qiao, J.X, Wang, Y.F, Yang, S.Y, Lei, J. | Deposit date: | 2020-09-19 | Release date: | 2020-10-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.004 Å) | Cite: | SARS-CoV-2 M pro inhibitors with antiviral activity in a transgenic mouse model. Science, 371, 2021
|
|
8JBJ
| Crystal structure of anti-PVRIG Fab | Descriptor: | antibody heavy chain, antibody light chain | Authors: | Sun, J, Li, X.L, Song, J. | Deposit date: | 2023-05-09 | Release date: | 2023-06-21 | Method: | X-RAY DIFFRACTION (1.61 Å) | Cite: | Identification and characterization of an unexpected isomerization motif in CDRH2 that affects antibody activity. Mabs, 15, 2023
|
|
8JEL
| |
8JEO
| Crystal structure of TIGIT in complexed with Tiragolumab | Descriptor: | T-cell immunoreceptor with Ig and ITIM domains, antibody heavy chain, antibody light chain | Authors: | Sun, J, Zhang, X.X, Song, J. | Deposit date: | 2023-05-16 | Release date: | 2024-02-28 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Structural insights into the unique pH-responsive characteristics of the anti-TIGIT therapeutic antibody Ociperlimab. Structure, 2024
|
|
8JEP
| Crystal structure of Ociperlimab | Descriptor: | antibody heavy chain, antibody light chain | Authors: | Sun, J, Zhang, X.X, Song, J. | Deposit date: | 2023-05-16 | Release date: | 2024-02-28 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural insights into the unique pH-responsive characteristics of the anti-TIGIT therapeutic antibody Ociperlimab. Structure, 2024
|
|
8JEQ
| Crystal structure of Tiragolumab | Descriptor: | antibody heavy chain, antibody light chain | Authors: | Sun, J, Zhang, X.X, Song, J. | Deposit date: | 2023-05-16 | Release date: | 2024-02-28 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Structural insights into the unique pH-responsive characteristics of the anti-TIGIT therapeutic antibody Ociperlimab. Structure, 2024
|
|
8JEN
| |
7MBO
| FACTOR XIA (PICHIA PASTORIS; C500S [C122S]) IN COMPLEX WITH THE INHIBITOR Milvexian (BMS-986177), IUPAC NAME:(6R,10S)-10-{4-[5-chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)phenyl]-6- oxopyrimidin-1(6H)-yl}-1-(difluoromethyl)-6-methyl-1,4,7,8,9,10-hexahydro-15,11- (metheno)pyrazolo[4,3-b][1,7]diazacyclotetradecin-5(6H)-one | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Coagulation factor XIa light chain, Milvexian | Authors: | Sheriff, S. | Deposit date: | 2021-04-01 | Release date: | 2021-09-15 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (0.924 Å) | Cite: | Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy. J.Med.Chem., 65, 2022
|
|
2H5E
| Crystal structure of E.coli polypeptide release factor RF3 | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Peptide chain release factor RF-3 | Authors: | Song, H.W, Zhou, Z.H. | Deposit date: | 2006-05-26 | Release date: | 2007-05-15 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | RF3 induces ribosomal conformational changes responsible for dissociation of class I release factors Cell(Cambridge,Mass.), 129, 2007
|
|
2LJV
| Solution structure of Rhodostomin G50L mutant | Descriptor: | Disintegrin rhodostomin | Authors: | Chuang, W, Shiu, J, Chen, C, Chen, Y, Chang, Y, Huang, C. | Deposit date: | 2011-09-29 | Release date: | 2012-10-03 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Design of Integrin AlphaVbeta3-Specific Disintegrin for Cancer Therapy To be Published
|
|
7TZL
| The DH dehydratase domain of AlnB | Descriptor: | 3-oxoacyl-[acyl-carrier-protein] reductase | Authors: | Swain, K, Blackson, W, Wang, B, Zhao, H, Nannenga, B.L. | Deposit date: | 2022-02-16 | Release date: | 2023-02-22 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | The programming of alpha,beta-polyene biosynthesis by a bacterial iterative type I polyketide synthase To Be Published
|
|
6AHU
| Cryo-EM structure of human Ribonuclease P with mature tRNA | Descriptor: | H1 RNA, Ribonuclease P protein subunit p14, Ribonuclease P protein subunit p20, ... | Authors: | Wu, J, Niu, S, Tan, M, Lan, P, Lei, M. | Deposit date: | 2018-08-20 | Release date: | 2018-12-05 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.66 Å) | Cite: | Cryo-EM Structure of the Human Ribonuclease P Holoenzyme. Cell, 175, 2018
|
|