8XQL
| Structure of human class T GPCR TAS2R14-miniGs/gust complex with Aristolochic acid A. | Descriptor: | 8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid, CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, ... | Authors: | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | Deposit date: | 2024-01-05 | Release date: | 2024-07-10 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (2.99 Å) | Cite: | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol. Nature, 631, 2024
|
|
8XQT
| Structure of human class T GPCR TAS2R14-Gi complex. | Descriptor: | CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Hu, X.L, Pei, Y, Wu, L.J, Hua, T, Liu, Z.J. | Deposit date: | 2024-01-05 | Release date: | 2024-07-10 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (2.94 Å) | Cite: | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol. Nature, 631, 2024
|
|
8XQR
| Structure 2 of human class T GPCR TAS2R14-miniGs/gust complex with Flufenamic acid. | Descriptor: | 2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | Deposit date: | 2024-01-05 | Release date: | 2024-07-10 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol. Nature, 631, 2024
|
|
8XQO
| Structure of human class T GPCR TAS2R14-Gi complex with Aristolochic acid A. | Descriptor: | 8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid, CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, ... | Authors: | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | Deposit date: | 2024-01-05 | Release date: | 2024-07-10 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (2.77 Å) | Cite: | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol. Nature, 631, 2024
|
|
8XQS
| Structure of human class T GPCR TAS2R14-DNGi complex with Flufenamic acid. | Descriptor: | 2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID, CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, ... | Authors: | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | Deposit date: | 2024-01-05 | Release date: | 2024-07-10 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol. Nature, 631, 2024
|
|
2NQ6
| |
2NQ7
| Crystal structure of type 1 human methionine aminopeptidase in complex with 3-(2,2-Dimethylpropionylamino)pyridine-2-carboxylic acid thiazole-2-ylamide | Descriptor: | 3-[(2,2-DIMETHYLPROPANOYL)AMINO]-N-1,3-THIAZOL-2-YLPYRIDINE-2-CARBOXAMIDE, COBALT (II) ION, GLYCEROL, ... | Authors: | Addlagatta, A, Matthews, B.W. | Deposit date: | 2006-10-30 | Release date: | 2006-11-21 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression. Proc.Natl.Acad.Sci.Usa, 103, 2006
|
|
8H85
| Trans-3/4-proline-hydroxylase H11 with 3-hydroxyl-proline | Descriptor: | 3-HYDROXYPROLINE, Phytanoyl-CoA dioxygenase | Authors: | Gong, W.M, Hu, X.Y. | Deposit date: | 2022-10-21 | Release date: | 2023-04-19 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Structures of L-proline trans-hydroxylase reveal the catalytic specificity and provide deeper insight into AKG-dependent hydroxylation. Acta Crystallogr D Struct Biol, 79, 2023
|
|
8H7T
| Trans-3/4-proline-hydroxylase H11 apo structure | Descriptor: | CHLORIDE ION, Phytanoyl-CoA dioxygenase | Authors: | Gong, W.M, Hu, X.Y. | Deposit date: | 2022-10-21 | Release date: | 2023-04-19 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Structures of L-proline trans-hydroxylase reveal the catalytic specificity and provide deeper insight into AKG-dependent hydroxylation. Acta Crystallogr D Struct Biol, 79, 2023
|
|
8H81
| Trans-3/4-proline-hydroxylase H11 with 4-Hydroxyl-proline | Descriptor: | 4-HYDROXYPROLINE, Phytanoyl-CoA dioxygenase | Authors: | Gong, W.M, Hu, X.Y. | Deposit date: | 2022-10-21 | Release date: | 2023-04-19 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Structures of L-proline trans-hydroxylase reveal the catalytic specificity and provide deeper insight into AKG-dependent hydroxylation. Acta Crystallogr D Struct Biol, 79, 2023
|
|
8H7V
| Trans-3/4-proline-hydroxylase H11 with AKG | Descriptor: | 2-OXOGLUTARIC ACID, FE (III) ION, Phytanoyl-CoA dioxygenase | Authors: | Gong, W.M, Hu, X.Y. | Deposit date: | 2022-10-21 | Release date: | 2023-04-19 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Structures of L-proline trans-hydroxylase reveal the catalytic specificity and provide deeper insight into AKG-dependent hydroxylation. Acta Crystallogr D Struct Biol, 79, 2023
|
|
8H7Y
| Trans-3/4-proline-hydroxylase H11 with AKG and L-proline | Descriptor: | 2-OXOGLUTARIC ACID, FE (III) ION, PROLINE, ... | Authors: | Gong, W.M, Hu, X.Y. | Deposit date: | 2022-10-21 | Release date: | 2023-04-19 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Structures of L-proline trans-hydroxylase reveal the catalytic specificity and provide deeper insight into AKG-dependent hydroxylation. Acta Crystallogr D Struct Biol, 79, 2023
|
|
8T8N
| |
5EZS
| |
5EZQ
| |
5UY9
| Prolyl isomerase Pin1 R14A mutant bound with Brd4 peptide | Descriptor: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Brd4 peptide, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, ... | Authors: | Dong, S.-H, Nair, S. | Deposit date: | 2017-02-23 | Release date: | 2017-04-26 | Last modified: | 2018-01-24 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Prolyl isomerase PIN1 regulates the stability, transcriptional activity and oncogenic potential of BRD4. Oncogene, 36, 2017
|
|
7XE4
| structure of a membrane-bound glycosyltransferase | Descriptor: | (11R,14S)-17-amino-14-hydroxy-8,14-dioxo-9,13,15-trioxa-14lambda~5~-phosphaheptadecan-11-yl decanoate, 1,3-beta-glucan synthase component FKS1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Hu, X.L, Yang, P, Zhang, M, Liu, X.T, Yu, H.J. | Deposit date: | 2022-03-29 | Release date: | 2023-03-29 | Last modified: | 2023-04-19 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural and mechanistic insights into fungal beta-1,3-glucan synthase FKS1. Nature, 616, 2023
|
|
7YGQ
| Crystal structure of SARS main protease in complex with inhibitor YH-53 | Descriptor: | 3C-like proteinase nsp5, N-[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-1-oxidanylidene-3-[(3S)-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]-4-methoxy-1H-indole-2-carboxamide | Authors: | Lin, C, Zhong, F.L, Zhou, X.L, Zeng, P, Zhang, J, Li, J. | Deposit date: | 2022-07-12 | Release date: | 2022-12-21 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Structural Basis for the Inhibition of Coronaviral Main Proteases by a Benzothiazole-Based Inhibitor. Viruses, 14, 2022
|
|
7XRY
| Crystal structure of MERS main protease in complex with inhibitor YH-53 | Descriptor: | N-[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-1-oxidanylidene-3-[(3S)-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]-4-methoxy-1H-indole-2-carboxamide, ORF1a | Authors: | Lin, C, Zhong, F.L, Zhou, X.L, Li, J, Zhang, J. | Deposit date: | 2022-05-12 | Release date: | 2022-12-21 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Structural Basis for the Inhibition of Coronaviral Main Proteases by a Benzothiazole-Based Inhibitor. Viruses, 14, 2022
|
|
7XRS
| Crystal structure of SARS-Cov-2 main protease in complex with inhibitor YH-53 | Descriptor: | N-[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-1-oxidanylidene-3-[(3S)-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]-4-methoxy-1H-indole-2-carboxamide, Replicase polyprotein 1a | Authors: | Zhou, X.L, Zhong, F.L, Lin, C, Zeng, P, Zhang, J, Li, J. | Deposit date: | 2022-05-11 | Release date: | 2022-12-21 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Structural Basis for the Inhibition of Coronaviral Main Proteases by a Benzothiazole-Based Inhibitor. Viruses, 14, 2022
|
|
3X1D
| |
6IJX
| Crystal Structure of AKR1C1 complexed with meclofenamic acid | Descriptor: | 2-[(2,6-dichloro-3-methyl-phenyl)amino]benzoic acid, Aldo-keto reductase family 1 member C1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Zheng, X, Zhao, Y, Zhang, L, Zhang, H, Chen, Y, Hu, X. | Deposit date: | 2018-10-12 | Release date: | 2019-10-16 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Screening, synthesis, crystal structure, and molecular basis of 6-amino-4-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles as novel AKR1C3 inhibitors. Bioorg.Med.Chem., 26, 2018
|
|
7RTS
| |
7RX1
| |
7S2Z
| |