5EZS

Venezuelan Equine Encephalitis Virus (VEEV) Nonstructural Protein 2 (nsP2) Cysteine Protease Inhibited by E64d

Summary for 5EZS

• Entry DOI: 10.2210/pdb5ezs/pdb
• Related: 5EZQ
• Descriptor: Non-structural Protein 2 Cysteine Protease, ethyl (3S)-3-hydroxy-4-({(2S)-4-methyl-1-[(3-methylbutyl)amino]-1-oxopentan-2-yl}amino)-4-oxobutanoate (3 entities in total)
• Functional Keywords: papain-like cysteine protease, clan cn, e64d adduct, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Venezuelan equine encephalitis virus (strain Trinidad donkey) (VEEV)
• Total number of polymer chains: 1
• Total formula weight: 38686.24

Authors

Legler, P.M. (deposition date: 2015-11-26, release date: 2016-04-13, Last modification date: 2023-09-27)

• Primary citation: Hu, X.,Compton, J.R.,Leary, D.H.,Olson, M.A.,Lee, M.S.,Cheung, J.,Ye, W.,Ferrer, M.,Southall, N.,Jadhav, A.,Morazzani, E.M.,Glass, P.J.,Marugan, J.,Legler, P.M.; Kinetic, Mutational, and Structural Studies of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease.; Biochemistry, 55:3007-3019, 2016; PubMed: 27030368; DOI: 10.1021/acs.biochem.5b00992

Experimental method

X-RAY DIFFRACTION (2.16 Å)