5EZS
Venezuelan Equine Encephalitis Virus (VEEV) Nonstructural Protein 2 (nsP2) Cysteine Protease Inhibited by E64d
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue E6D A 801 |
| Chain | Residue |
| A | ALA474 |
| A | ASN545 |
| A | HIS546 |
| A | TRP547 |
| A | ILE698 |
| A | MET702 |
| A | HOH901 |
| A | HOH998 |
| A | ASN475 |
| A | VAL476 |
| A | CYS477 |
| A | TRP478 |
| A | ALA509 |
| A | HIS510 |
| A | SER511 |
| A | ILE542 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 319 |
| Details | Domain: {"description":"Peptidase C9","evidences":[{"source":"PROSITE-ProRule","id":"PRU00853","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27318152","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 19 |
| Details | Region: {"description":"Nucleolus localization signal","evidences":[{"source":"UniProtKB","id":"P08411","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 9 |
| Details | Motif: {"description":"Nuclear export signal","evidences":[{"source":"PubMed","id":"17652399","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Motif: {"description":"Nuclear localization signal","evidences":[{"source":"PubMed","id":"17652399","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For cysteine protease nsP2 activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00853","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16962975","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
