1FNK
 
 | | CRYSTAL STRUCTURE ANALYSIS OF CHORISMATE MUTASE MUTANT C88K/R90S | | 分子名称: | PROTEIN (CHORISMATE MUTASE) | | 著者 | Kast, P, Grisostomi, C, Chen, I.A, Li, S, Krengel, U, Xue, Y, Hilvert, D. | | 登録日 | 2000-08-22 | | 公開日 | 2000-10-11 | | 最終更新日 | 2021-11-03 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | A strategically positioned cation is crucial for efficient catalysis by chorismate mutase.
J.Biol.Chem., 275, 2000
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1FNJ
 | | CRYSTAL STRUCTURE ANALYSIS OF CHORISMATE MUTASE MUTANT C88S/R90K | | 分子名称: | PROTEIN (CHORISMATE MUTASE) | | 著者 | Kast, P, Grisostomi, C, Chen, I.A, Li, S, Krengel, U, Xue, Y, Hilvert, D. | | 登録日 | 2000-08-22 | | 公開日 | 2000-10-11 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | A strategically positioned cation is crucial for efficient catalysis by chorismate mutase.
J.Biol.Chem., 275, 2000
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8QBA
 | | Sperm whale myoblogin mutant H64V V68A in complex with glycine ethyl ester | | 分子名称: | ACETATE ION, Myoglobin, PROTOPORPHYRIN IX CONTAINING FE, ... | | 著者 | Tinzl, M, Mittl, P.R.E, Hilvert, D. | | 登録日 | 2023-08-24 | | 公開日 | 2023-12-13 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.39 Å) | | 主引用文献 | Myoglobin-Catalyzed Azide Reduction Proceeds via an Anionic Metal Amide Intermediate.
J.Am.Chem.Soc., 146, 2024
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8QBC
 | | Reactive amide intermediate in sperm whale myoglobin mutant H64V V68A | | 分子名称: | ACETATE ION, Myoglobin, PROTOPORPHYRIN IX CONTAINING FE, ... | | 著者 | Tinzl, M, Mittl, P.R.E, Hilvert, D. | | 登録日 | 2023-08-24 | | 公開日 | 2023-12-13 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.23 Å) | | 主引用文献 | Myoglobin-Catalyzed Azide Reduction Proceeds via an Anionic Metal Amide Intermediate.
J.Am.Chem.Soc., 146, 2024
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6NW4
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4JXI
 | | Directed evolution and rational design of a de novo designed esterase toward improved catalysis. Northeast Structural Genomics Consortium (NESG) Target OR184 | | 分子名称: | 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, BROMIDE ION, GLYCEROL, ... | | 著者 | Kuzin, A, Smith, M.D, Richter, F, Lew, S, Seetharaman, R, Bryan, C, Lech, Z, Kiss, G, Moretti, R, Maglaqui, M, Xiao, R, Kohan, E, Smith, M, Everett, J.K, Nguyen, R, Pande, V, Hilvert, D, Kornhaber, G, Baker, D, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2013-03-28 | | 公開日 | 2013-05-22 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | | 主引用文献 | Directed evolution and rational design of a de novo designed esterase toward improved catalysis. Northeast Structural Genomics Consortium (NESG) Target OR184
To be Published
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8AH9
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7BWW
 | | Structure of the engineered metallo-Diels-Alderase DA7 W16S | | 分子名称: | ACETIC ACID, BENZOIC ACID, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Basler, S, Mori, T, Hilvert, D. | | 登録日 | 2020-04-16 | | 公開日 | 2021-04-21 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Efficient Lewis acid catalysis of an abiological reaction in a de novo protein scaffold.
Nat.Chem., 13, 2021
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5AN7
 | | Structure of the engineered retro-aldolase RA95.5-8F with a bound 1,3-diketone inhibitor | | 分子名称: | (2E)-1-(6-methoxynaphthalen-2-yl)but-2-en-1-one, PHOSPHATE ION, RA95.5-8F | | 著者 | Obexer, R, Mittl, P.R.E, Hilvert, D. | | 登録日 | 2015-09-04 | | 公開日 | 2016-08-17 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Emergence of a catalytic tetrad during evolution of a highly active artificial aldolase.
Nat Chem, 9, 2017
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5AOU
 | | Structure of the engineered retro-aldolase RA95.5-8F apo | | 分子名称: | 1,2-ETHANEDIOL, INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE, PHOSPHATE ION | | 著者 | Obexer, R, Mittl, P, Hilvert, D. | | 登録日 | 2015-09-11 | | 公開日 | 2016-08-17 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Emergence of a catalytic tetrad during evolution of a highly active artificial aldolase.
Nat Chem, 9, 2017
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1SEL
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6WXP
 | | De novo TIM barrel-ferredoxin fold fusion homodimer with 4-glutamate centre TFD-EE | | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, TFD-EE | | 著者 | Caldwell, S.J, Zeymer, C, Haydon, I.C, Huang, P, Hilvert, D, Baker, D. | | 登録日 | 2020-05-11 | | 公開日 | 2020-11-25 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Tight and specific lanthanide binding in a de novo TIM barrel with a large internal cavity designed by symmetric domain fusion.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6WXO
 | | De novo TIM barrel-ferredoxin fold fusion homodimer with 2-histidine 2-glutamate centre TFD-HE | | 分子名称: | GLYCEROL, SULFATE ION, TFD-HE | | 著者 | Caldwell, S.J, Zeymer, C, Haydon, I.C, Huang, P, Hilvert, D, Baker, D. | | 登録日 | 2020-05-11 | | 公開日 | 2020-11-25 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.41 Å) | | 主引用文献 | Tight and specific lanthanide binding in a de novo TIM barrel with a large internal cavity designed by symmetric domain fusion.
Proc.Natl.Acad.Sci.USA, 117, 2020
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1UBN
 | | SELENOSUBTILISIN BPN | | 分子名称: | CALCIUM ION, PROTEIN (SELENOSUBTILISIN BPN) | | 著者 | McRee, D.E, McTigue, M, Hilvert, D. | | 登録日 | 1999-06-02 | | 公開日 | 1999-06-08 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Electric fields in active sites: substrate switching from null to strong fields in thiol- and selenol-subtilisins.
Biochemistry, 38, 1999
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7YWJ
 | | Crystal structure of an engineered TycA variant, TycA pPLA (L313P) | | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, SULFATE ION, ... | | 著者 | Mittl, P, Camus, A, Truong, G, Markert, G, Hilvert, D. | | 登録日 | 2022-02-14 | | 公開日 | 2022-09-21 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.749 Å) | | 主引用文献 | Reprogramming Nonribosomal Peptide Synthetases for Site-Specific Insertion of alpha-Hydroxy Acids.
J.Am.Chem.Soc., 144, 2022
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7YWK
 | | Crystal structure of an engineered TycA variant, TycApPLA, in complex with AMP | | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE MONOPHOSPHATE, CHLORIDE ION, ... | | 著者 | Mittl, P, Camus, A, Truong, G, Markert, G, Hilvert, D. | | 登録日 | 2022-02-14 | | 公開日 | 2022-09-21 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.39 Å) | | 主引用文献 | Reprogramming Nonribosomal Peptide Synthetases for Site-Specific Insertion of alpha-Hydroxy Acids.
J.Am.Chem.Soc., 144, 2022
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1FIG
 | | ROUTES TO CATALYSIS: STRUCTURE OF A CATALYTIC ANTIBODY AND COMPARISON WITH ITS NATURAL COUNTERPART | | 分子名称: | 8-HYDROXY-2-OXA-BICYCLO[3.3.1]NON-6-ENE-3,5-DICARBOXYLIC ACID, IGG1-KAPPA 1F7 FAB (HEAVY CHAIN), IGG1-KAPPA 1F7 FAB (LIGHT CHAIN) | | 著者 | Haynes, M.R, Stura, E.A, Hilvert, D, Wilson, I.A. | | 登録日 | 1994-01-07 | | 公開日 | 1994-05-31 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Routes to catalysis: structure of a catalytic antibody and comparison with its natural counterpart.
Science, 263, 1994
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5MPP
 | | Structure of AaLS-wt | | 分子名称: | 6,7-dimethyl-8-ribityllumazine synthase | | 著者 | Sasaki, E, Boehringer, D, Leibundgut, M, Ban, N, Hilvert, D. | | 登録日 | 2016-12-17 | | 公開日 | 2017-03-22 | | 最終更新日 | 2019-10-23 | | 実験手法 | ELECTRON MICROSCOPY (3.94 Å) | | 主引用文献 | Structure and assembly of scalable porous protein cages.
Nat Commun, 8, 2017
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5MQ7
 | | Structure of AaLS-13 | | 分子名称: | 6,7-dimethyl-8-ribityllumazine synthase | | 著者 | Sasaki, E, Boehringer, D, Leibundgut, M, Ban, N, Hilvert, D. | | 登録日 | 2016-12-20 | | 公開日 | 2017-03-22 | | 実験手法 | ELECTRON MICROSCOPY (5.2 Å) | | 主引用文献 | Structure and assembly of scalable porous protein cages.
Nat Commun, 8, 2017
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5MQ3
 | | Structure of AaLS-neg | | 分子名称: | 6,7-dimethyl-8-ribityllumazine synthase | | 著者 | Sasaki, E, Boehringer, D, Leibundgut, M, Ban, N, Hilvert, D. | | 登録日 | 2016-12-20 | | 公開日 | 2017-03-22 | | 実験手法 | ELECTRON MICROSCOPY (5.4 Å) | | 主引用文献 | Structure and assembly of scalable porous protein cages.
Nat Commun, 8, 2017
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5N82
 | | Crystal structure of an engineered TycA variant in complex with an beta-Phe-AMP analog | | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SULFATE ION, Tyrocidine synthase 1, ... | | 著者 | Niquille, D.L, Hansen, D.L, Mori, T, Fercher, D, Kries, H, Hilvert, D. | | 登録日 | 2017-02-22 | | 公開日 | 2017-12-13 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.708 Å) | | 主引用文献 | Nonribosomal biosynthesis of backbone-modified peptides.
Nat Chem, 10, 2018
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5N81
 | | Crystal structure of an engineered TycA variant in complex with an O-propargyl-beta-Tyr-AMP analog | | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SULFATE ION, Tyrocidine synthase 1, ... | | 著者 | Niquille, D.L, Hansen, D.A, Mori, T, Fercher, D, Kries, H, Hilvert, D. | | 登録日 | 2017-02-22 | | 公開日 | 2017-12-13 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Nonribosomal biosynthesis of backbone-modified peptides.
Nat Chem, 10, 2018
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4O5T
 | | Crystal structure of Diels-Alderase CE20 in complex with a product analog | | 分子名称: | 4-{[2-(phosphonooxy)ethyl]carbamoyl}benzyl [(1R,6S)-6-(dimethylcarbamoyl)cyclohex-2-en-1-yl]carbamate, Diisopropyl-fluorophosphatase | | 著者 | Beck, T, Preiswerk, N, Mayer, C, Hilvert, D. | | 登録日 | 2013-12-20 | | 公開日 | 2014-06-04 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Impact of scaffold rigidity on the design and evolution of an artificial Diels-Alderase.
Proc.Natl.Acad.Sci.USA, 111, 2014
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4O5S
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7A4J
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