5N81

Crystal structure of an engineered TycA variant in complex with an O-propargyl-beta-Tyr-AMP analog

Summary for 5N81

Entry DOI	10.2210/pdb5n81/pdb
Descriptor	Tyrocidine synthase 1, [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl ~{N}-[(3~{S})-3-azanyl-3-(4-prop-2-ynoxyphenyl)propanoyl]sulfamate, SULFATE ION, ... (5 entities in total)
Functional Keywords	nonribosomal peptide synthetase, adenylation domain, ligase
Biological source	Brevibacillus parabrevis
Total number of polymer chains	2
Total formula weight	96870.49
Authors	Niquille, D.L.,Hansen, D.A.,Mori, T.,Fercher, D.,Kries, H.,Hilvert, D. (deposition date: 2017-02-22, release date: 2017-12-13, Last modification date: 2024-01-17)
Primary citation	Niquille, D.L.,Hansen, D.A.,Mori, T.,Fercher, D.,Kries, H.,Hilvert, D. Nonribosomal biosynthesis of backbone-modified peptides. Nat Chem, 10:282-287, 2018 Cited by PubMed: 29461527 DOI: 10.1038/nchem.2891 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation