5AN7

Structure of the engineered retro-aldolase RA95.5-8F with a bound 1,3-diketone inhibitor

Summary for 5AN7

Entry DOI	10.2210/pdb5an7/pdb
Related	5AOU
Descriptor	RA95.5-8F, PHOSPHATE ION, (2E)-1-(6-methoxynaphthalen-2-yl)but-2-en-1-one, ... (4 entities in total)
Functional Keywords	lyase, retro-aldolase, protein engineering, enzyme design, directed evolution
Biological source	SULFOLOBUS SOLFATARICUS
Total number of polymer chains	1
Total formula weight	30352.65
Authors	Obexer, R.,Mittl, P.R.E.,Hilvert, D. (deposition date: 2015-09-04, release date: 2016-08-17, Last modification date: 2024-01-10)
Primary citation	Obexer, R.,Godina, A.,Garrabou, X.,Mittl, P.R.,Baker, D.,Griffiths, A.D.,Hilvert, D. Emergence of a catalytic tetrad during evolution of a highly active artificial aldolase. Nat Chem, 9:50-56, 2017 Cited by PubMed: 27995916 DOI: 10.1038/nchem.2596 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.1 Å)

Structure validation