1Q5H
| Human dUTP Pyrophosphatase complex with dUDP | 分子名称: | DEOXYURIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, dUTP pyrophosphatase | 著者 | Mol, C.D, Harris, J.M, McIntosh, E.M, Tainer, J.A. | 登録日 | 2003-08-07 | 公開日 | 2003-08-19 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Human dUTP pyrophosphatase: uracil recognition by a Beta hairpin and active sites formed by three separate subunits Structure, 4, 1996
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1Q5U
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4K8Y
| Atomic resolution crystal structures of Kallikrein-Related Peptidase 4 complexed with Sunflower Trypsin Inhibitor (SFTI-1) | 分子名称: | Kallikrein-4, Trypsin inhibitor 1 | 著者 | Ilyichova, O.V, Swedberg, J.E, de Veer, S.J, Sit, K.C, Harris, J.M, Buckle, A.M. | 登録日 | 2013-04-19 | 公開日 | 2014-04-23 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1 Å) | 主引用文献 | Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics Sci Rep, 6, 2016
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4KEL
| Atomic resolution crystal structure of Kallikrein-Related Peptidase 4 complexed with a modified SFTI inhibitor FCQR(N) | 分子名称: | Kallikrein-4, Trypsin inhibitor 1 | 著者 | Ilyichova, O.V, Swedberg, J.E, de Veer, S.J, Sit, K.C, Harris, J.M, Buckle, A.M. | 登録日 | 2013-04-25 | 公開日 | 2014-04-30 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.148 Å) | 主引用文献 | KLK4 Inhibition by Cyclic and Acyclic Peptides: Structural and Dynamical Insights into Standard-Mechanism Protease Inhibitors. Biochemistry, 58, 2019
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4K1E
| Atomic resolution crystal structures of Kallikrein-Related Peptidase 4 complexed with a modified SFTI inhibitor FCQR | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Kallikrein-4, LITHIUM ION, ... | 著者 | Ilyichova, O.V, Swedberg, J.E, de Veer, S.J, Sit, K.C, Harris, J.M, Buckle, A.M. | 登録日 | 2013-04-04 | 公開日 | 2014-04-09 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics Sci Rep, 6, 2016
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4KGA
| Crystal structure of kallikrein-related peptidase 4 | 分子名称: | 1,2-ETHANEDIOL, Kallikrein-4, NICKEL (II) ION | 著者 | Ilyichova, O.V, Swedberg, J.E, de Veer, S.J, Sit, K.C, Harris, J.M, Buckle, A.M. | 登録日 | 2013-04-29 | 公開日 | 2014-04-30 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | 主引用文献 | Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics Sci Rep, 6, 2016
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8B3Z
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6O21
| Crystal Structure of Human KLK4 in Complex With Cleaved SFTI-FCQR(Asn14)[1,14] Inhibitor | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Kallikrein 4 (Prostase, enamel matrix, ... | 著者 | Ilyichova, O.V, Buckle, A.M. | 登録日 | 2019-02-22 | 公開日 | 2019-03-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | KLK4 Inhibition by Cyclic and Acyclic Peptides: Structural and Dynamical Insights into Standard-Mechanism Protease Inhibitors. Biochemistry, 58, 2019
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6BVH
| Trypsin complexed with a modified sunflower trypsin inhibitor, SFTI-TCTR(N12,N14) | 分子名称: | CALCIUM ION, Cationic trypsin, GLYCEROL, ... | 著者 | Riley, B.T, Chen, X. | 登録日 | 2017-12-13 | 公開日 | 2018-12-19 | 最終更新日 | 2019-01-30 | 実験手法 | X-RAY DIFFRACTION (1.927 Å) | 主引用文献 | Potent, multi-target serine protease inhibition achieved by a simplified beta-sheet motif. PLoS ONE, 14, 2019
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6NOX
| Solution structure of SFTI-KLK5 inhibitor | 分子名称: | SFTI-KLK5 Peptide | 著者 | White, A.M. | 登録日 | 2019-01-16 | 公開日 | 2019-04-03 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Amino Acid Scanning at P5' within the Bowman-Birk Inhibitory Loop Reveals Specificity Trends for Diverse Serine Proteases. J. Med. Chem., 62, 2019
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3L3Q
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2HQU
| Human dUTPase in complex with alpha,beta-iminodUTP and magnesium ion | 分子名称: | 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CHLORIDE ION, Deoxyuridine 5'-triphosphate nucleotidohydrolase, ... | 著者 | Barabas, O, Varga, B, Vertessy, B.G. | 登録日 | 2006-07-19 | 公開日 | 2007-07-24 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Active site closure facilitates juxtaposition of reactant atoms for initiation of catalysis by human dUTPase. Febs Lett., 581, 2007
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1MQ7
| CRYSTAL STRUCTURE OF DUTPASE FROM MYCOBACTERIUM TUBERCULOSIS (RV2697C) | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE | 著者 | Sawaya, M.R, Chan, S, Segelke, B.W, Lekin, T, Heike, K, Cho, U.S, Naranjo, C, Perry, L.J, Yeates, T.O, Eisenberg, D, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2002-09-13 | 公開日 | 2002-10-09 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Crystal structure of the Mycobacterium tuberculosis dUTPase: insights into the catalytic mechanism. J.Mol.Biol., 341, 2004
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3EHW
| Human dUTPase in complex with alpha,beta-imido-dUTP and Mg2+: visualization of the full-length C-termini in all monomers and suggestion for an additional metal ion binding site | 分子名称: | 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, MAGNESIUM ION, dUTP pyrophosphatase | 著者 | Takacs, E, Barabas, O, Vertessy, B.G. | 登録日 | 2008-09-15 | 公開日 | 2008-09-30 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Human dUTPase in complex with alpha,beta-imido-dUTP and Mg2+: visualization of the full-length C-termini in all monomers and suggestion for an additional metal ion binding site To be Published
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