2HQU

Human dUTPase in complex with alpha,beta-iminodUTP and magnesium ion

Summary for 2HQU

DescriptorDeoxyuridine 5'-triphosphate nucleotidohydrolase, MAGNESIUM ION, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, ... (5 entities in total)
Functional Keywordsjelly-roll, protein-substrate analogue ligand complex, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationIsoform 2: Nucleus . Isoform 3: Mitochondrion  P33316
Total number of polymer chains3
Total molecular weight54847.35
Authors
Barabas, O.,Varga, B.,Vertessy, B.G. (deposition date: 2006-07-19, release date: 2007-07-24, Last modification date: 2016-10-19)
Primary citation
Varga, B.,Barabas, O.,Kovari, J.,Toth, J.,Hunyadi-Gulyas, E.,Klement, E.,Medzihradszky, K.F.,Tolgyesi, F.,Fidy, J.,Vertessy, B.G.
Active site closure facilitates juxtaposition of reactant atoms for initiation of catalysis by human dUTPase.
Febs Lett., 581:4783-4788, 2007
PubMed: 17880943 (PDB entries with the same primary citation)
DOI: 10.1016/j.febslet.2007.09.005
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.2 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.25970.3%7.7%0.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report