4KEL

Atomic resolution crystal structure of Kallikrein-Related Peptidase 4 complexed with a modified SFTI inhibitor FCQR(N)

Summary for 4KEL

Entry DOI	10.2210/pdb4kel/pdb
Related	2bdg 2bdh 2bdi 4K1E 4K8Y 4KGA
Related PRD ID	PRD_001059
Descriptor	Kallikrein-4, Trypsin inhibitor 1 (3 entities in total)
Functional Keywords	bowman-birk inhibitor, protease, protease inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	25505.87
Authors	Ilyichova, O.V.,Swedberg, J.E.,de Veer, S.J.,Sit, K.C.,Harris, J.M.,Buckle, A.M. (deposition date: 2013-04-25, release date: 2014-04-30, Last modification date: 2023-11-08)
Primary citation	Riley, B.T.,Ilyichova, O.,de Veer, S.J.,Swedberg, J.E.,Wilson, E.,Hoke, D.E.,Harris, J.M.,Buckle, A.M. KLK4 Inhibition by Cyclic and Acyclic Peptides: Structural and Dynamical Insights into Standard-Mechanism Protease Inhibitors. Biochemistry, 58:2524-2533, 2019 Cited by PubMed: 31058493 DOI: 10.1021/acs.biochem.9b00191 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.148 Å)

Structure validation