4KEL
Atomic resolution crystal structure of Kallikrein-Related Peptidase 4 complexed with a modified SFTI inhibitor FCQR(N)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Kallikrein-4 | polymer | 223 | 23926.0 | 1 | UniProt (Q9Y5K2) Pfam (PF00089) In PDB | Homo sapiens (human) | Enamel matrix serine proteinase 1, Kallikrein-like protein 1, KLK-L1, Prostase, Serine protease 17 |
| 2 | B | Trypsin inhibitor 1 | polymer | 14 | 1579.9 | 1 | UniProt (Q4GWU5) In PDB BIRD (PRD_001059) | Helianthus annuus | SFTI-1 |
| 3 | water | water | 18.0 | 209 | Chemie (HOH) |
Sequence modifications
A: 16 - 244 (UniProt: Q9Y5K2)
B: 1 - 14 (UniProt: Q4GWU5)
| PDB | External Database | Details |
|---|---|---|
| Gln 186 | His 197 | SEE REMARK 999 |
| PDB | External Database | Details |
|---|---|---|
| Phe 2 | Arg 41 | engineered mutation |
| Gln 4 | Thr 43 | engineered mutation |
| Arg 5 | Lys 44 | engineered mutation |
| Asn 14 | Asp 53 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 25505.9 | |
| All* | Total formula weight | 25505.9 |
