4K8Y

Atomic resolution crystal structures of Kallikrein-Related Peptidase 4 complexed with Sunflower Trypsin Inhibitor (SFTI-1)

Summary for 4K8Y

• Entry DOI: 10.2210/pdb4k8y/pdb
• Related: 1SFI 2bdg 2bdh 2bdi 4K1E 4KEL 4KGA
• Related PRD ID: PRD_001097
• Descriptor: Kallikrein-4, Trypsin inhibitor 1 (3 entities in total)
• Functional Keywords: bowman-birk inhibitor, protease, protease inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: Q9Y5K2
• Total number of polymer chains: 2
• Total formula weight: 25461.84

Authors

Ilyichova, O.V.,Swedberg, J.E.,de Veer, S.J.,Sit, K.C.,Harris, J.M.,Buckle, A.M. (deposition date: 2013-04-19, release date: 2014-04-23, Last modification date: 2023-11-08)

• Primary citation: Riley, B.T.,Ilyichova, O.,Costa, M.G.S.,Porebski, B.T.,de Veer, S.J.,Swedberg, J.E.,Kass, I.,Harris, J.M.,Hoke, D.E.,Buckle, A.M.; Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics; Sci Rep, 6:35385-35385, 2016; PubMed: 27767076; DOI: 10.1038/srep35385

Experimental method

X-RAY DIFFRACTION (1 Å)