5VR4
 
 | | RNA octamer containing 2'-F-4'-OMe U. | | Descriptor: | COBALT TETRAAMMINE ION, RNA (5'-R(*CP*GP*AP*AP*(UMO)P*UP*CP*G)-3') | | Authors: | Harp, J.M, Egli, M. | | Deposit date: | 2017-05-10 | | Release date: | 2017-10-04 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | 4'-C-Methoxy-2'-deoxy-2'-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing.
J. Am. Chem. Soc., 139, 2017
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5V2H
 | | RNA octamer containing glycol nucleic acid, SgnT | | Descriptor: | COBALT HEXAMMINE(III), MAGNESIUM ION, RNA (5'-R(*(CBV)P*GP*AP*AP*(ZTH)P*UP*CP*G)-3') | | Authors: | Harp, J.M, Egli, M. | | Deposit date: | 2017-03-04 | | Release date: | 2017-06-14 | | Last modified: | 2022-06-22 | | Method: | X-RAY DIFFRACTION (1.080013 Å) | | Cite: | Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.
J. Am. Chem. Soc., 139, 2017
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3G1Q
 | | Crystal structure of sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei in ligand free state | | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, Sterol 14-alpha-demethylase | | Authors: | Lepesheva, G.I, Hargrove, T.Y, Harp, J, Wawrzak, Z, Waterman, M.R, Park, H. | | Deposit date: | 2009-01-30 | | Release date: | 2009-10-06 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.89 Å) | | Cite: | Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections.
J.Biol.Chem., 285, 2010
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3GW9
 | | Crystal structure of sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei bound to an inhibitor N-(1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxaziazol-2-yl)benzamide | | Descriptor: | N-[(1R)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl]-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide, PROTOPORPHYRIN IX CONTAINING FE, STEROL 14ALPHA-DEMETHYLASE | | Authors: | Lepesheva, G.I, Hargrove, T.Y, Harp, J, Wawrzak, Z, Waterman, M.R. | | Deposit date: | 2009-03-31 | | Release date: | 2009-11-17 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.87 Å) | | Cite: | Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections.
J.Biol.Chem., 285, 2010
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5V1K
 | | Structure of R-GNA dodecamer | | Descriptor: | RNA (5'-R(*CP*GP*CP*GP*AP*AP*(5BU)P*(8RJ)P*AP*GP*CP*G)-3') | | Authors: | Pallan, P.S, Egli, M. | | Deposit date: | 2017-03-02 | | Release date: | 2017-06-21 | | Last modified: | 2022-06-22 | | Method: | X-RAY DIFFRACTION (1.18 Å) | | Cite: | Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.
J. Am. Chem. Soc., 2017
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5V1L
 | | Structure of S-GNA dodecamer | | Descriptor: | RNA (5'-R(*CP*GP*CP*GP*AP*AP*UP*(ZTH)P*AP*GP*CP*G)-3'), SPERMINE, STRONTIUM ION | | Authors: | Pallan, P.S, Egli, M. | | Deposit date: | 2017-03-02 | | Release date: | 2017-06-14 | | Last modified: | 2022-06-22 | | Method: | X-RAY DIFFRACTION (1.2 Å) | | Cite: | Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.
J. Am. Chem. Soc., 139, 2017
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5WF1
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5WF9
 | | Tepsin tENTH domain 1-153 | | Descriptor: | AP-4 complex accessory subunit Tepsin | | Authors: | Archuleta, T.L, Jackson, L.P. | | Deposit date: | 2017-07-11 | | Release date: | 2017-08-02 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structure and evolution of ENTH and VHS/ENTH-like domains in tepsin.
Traffic, 18, 2017
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5WFB
 | | Tepsin tENTH domain 1-136. | | Descriptor: | AP-4 complex accessory subunit Tepsin | | Authors: | Archuleta, T.L, Jackson, L.P. | | Deposit date: | 2017-07-11 | | Release date: | 2017-07-26 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.382 Å) | | Cite: | Structure and evolution of ENTH and VHS/ENTH-like domains in tepsin.
Traffic, 18, 2017
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5WF2
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4HTU
 | | Structure of 5-chlorouracil modified A:U base pair | | Descriptor: | 1,2-ETHANEDIOL, DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*(UCL)P*CP*GP*CP*G)-3'), GLYCEROL, ... | | Authors: | Patra, A, Egli, M. | | Deposit date: | 2012-11-01 | | Release date: | 2012-12-19 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.489 Å) | | Cite: | Structure, stability and function of 5-chlorouracil modified A:U and G:U base pairs.
Nucleic Acids Res., 41, 2013
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4HUG
 | | Structure of 5-chlorouracil modified A:U base pairs | | Descriptor: | 1,2-ETHANEDIOL, DNA (5'-D(*CP*GP*CP*GP*AP*AP*(UCL)P*(UCL)P*CP*GP*CP*G)-3'), GLYCEROL, ... | | Authors: | Patra, A, Egli, M. | | Deposit date: | 2012-11-02 | | Release date: | 2012-12-19 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.64 Å) | | Cite: | Structure, stability and function of 5-chlorouracil modified A:U and G:U base pairs.
Nucleic Acids Res., 41, 2013
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4HUF
 | | Structure of 5-chlorouracil modified A:U base pair | | Descriptor: | 1,2-ETHANEDIOL, DNA (5'-D(*CP*GP*CP*GP*AP*AP*(UCL)P*TP*CP*GP*CP*G)-3'), GLYCEROL, ... | | Authors: | Patra, A, Egli, M. | | Deposit date: | 2012-11-02 | | Release date: | 2012-12-19 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.69 Å) | | Cite: | Structure, stability and function of 5-chlorouracil modified A:U and G:U base pairs.
Nucleic Acids Res., 41, 2013
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4HUE
 | | Structure of 5-chlorouracil modified G:U base pair | | Descriptor: | DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*(UCL)P*GP*CP*G)-3'), GLYCEROL, MAGNESIUM ION, ... | | Authors: | Patra, A, Egli, M. | | Deposit date: | 2012-11-02 | | Release date: | 2012-12-19 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.561 Å) | | Cite: | Structure, stability and function of 5-chlorouracil modified A:U and G:U base pairs.
Nucleic Acids Res., 41, 2013
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