7Q6A
| Crystal structure of Chaetomium thermophilum C30S Ahp1 in post-reaction state | Descriptor: | GLYCEROL, SULFATE ION, Thioredoxin domain-containing protein | Authors: | Ravichandran, K.E, Wilk, P, Grudnik, P, Glatt, S. | Deposit date: | 2021-11-05 | Release date: | 2022-08-24 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | E2/E3-independent ubiquitin-like protein conjugation by Urm1 is directly coupled to cysteine persulfidation. Embo J., 41, 2022
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7Q5N
| Crystal structure of Chaetomium thermophilum Ahp1-Urm1 complex | Descriptor: | Thioredoxin domain-containing protein, Ubiquitin-related modifier 1, ZINC ION | Authors: | Ravichandran, K.E, Wilk, P, Grudnik, P, Glatt, S. | Deposit date: | 2021-11-04 | Release date: | 2022-08-24 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | E2/E3-independent ubiquitin-like protein conjugation by Urm1 is directly coupled to cysteine persulfidation. Embo J., 41, 2022
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7Q68
| Crystal structure of Chaetomium thermophilum wild-type Ahp1 | Descriptor: | GLYCEROL, SULFATE ION, Thioredoxin domain-containing protein | Authors: | Ravichandran, K.E, Wilk, P, Grudnik, P, Glatt, S. | Deposit date: | 2021-11-05 | Release date: | 2022-08-31 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | E2/E3-independent ubiquitin-like protein conjugation by Urm1 is directly coupled to cysteine persulfidation. Embo J., 41, 2022
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5N2F
| Structure of PD-L1/small-molecule inhibitor complex | Descriptor: | 4-[[4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methyl-phenyl]methoxy]-2,5-bis(fluoranyl)phenyl]methylamino]-3-oxidanylidene-butanoic acid, Programmed cell death 1 ligand 1 | Authors: | Guzik, K, Zak, K.M, Grudnik, P, Dubin, G, Holak, T.A. | Deposit date: | 2017-02-07 | Release date: | 2017-06-28 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1. J. Med. Chem., 60, 2017
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5N86
| Crystal structure of FAS1 domain of hyaluronic acid receptor stabilin-2 | Descriptor: | Stabilin-2 | Authors: | Twarda-Clapa, A, Labuzek, B, Grudnik, P, Dubin, G, Holak, T.A. | Deposit date: | 2017-02-23 | Release date: | 2018-06-27 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.484 Å) | Cite: | Crystal structure of the FAS1 domain of the hyaluronic acid receptor stabilin-2. Acta Crystallogr D Struct Biol, 74, 2018
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5NIU
| Structure of human Programmed cell death 1 ligand 1 (PD-L1) with low molecular mass inhibitor | Descriptor: | (2~{R})-2-[[2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methyl-phenyl]methoxy]-5-methyl-phenyl]methylamino]-3-oxidanyl-propanoic acid, 1,2-ETHANEDIOL, Programmed cell death 1 ligand 1 | Authors: | Zak, K.M, Grudnik, P, Skalniak, L, Dubin, G, Holak, T.A. | Deposit date: | 2017-03-27 | Release date: | 2017-12-06 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells. Oncotarget, 8, 2017
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6R2N
| Crystal structure of KlGlk1 glucokinase from Kluyveromyces lactis | Descriptor: | 1,2-ETHANEDIOL, BROMIDE ION, Glucokinase-1 | Authors: | Zak, K, Wator, E, Grudnik, P. | Deposit date: | 2019-03-18 | Release date: | 2019-10-16 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.596 Å) | Cite: | Crystal Structure of Kluyveromyces lactis Glucokinase ( Kl Glk1). Int J Mol Sci, 20, 2019
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6SRU
| Structure of Ig-like V-type domian of mouse Programmed cell death 1 ligand 1 (PD-L1) | Descriptor: | Programmed cell death 1 ligand 1 | Authors: | Magiera-Mularz, K, Sala, D, Grudnik, P, Holak, T.A. | Deposit date: | 2019-09-06 | Release date: | 2021-02-03 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.532 Å) | Cite: | Human and mouse PD-L1: similar molecular structure, but different druggability profiles. Iscience, 24, 2021
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6ZQ5
| Crystal structure of Chaetomium thermophilum Glycerol Kinase in P2221 space group | Descriptor: | 1,2-ETHANEDIOL, Glycerol kinase-like protein | Authors: | Wilk, P, Wator, E, Malecki, P, Grudnik, P. | Deposit date: | 2020-07-09 | Release date: | 2020-12-23 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Structural Characterization of Glycerol Kinase from the Thermophilic Fungus Chaetomium thermophilum . Int J Mol Sci, 21, 2020
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6TXN
| Crystal structure of thermotoga maritima Ferritin in apo form | Descriptor: | EICOSANE, Ferritin, GLYCEROL, ... | Authors: | Wilk, P, Grudnik, P, Kumar, M, Heddle, J, Chakraborti, S. | Deposit date: | 2020-01-14 | Release date: | 2021-07-28 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | A single residue can modulate nanocage assembly in salt dependent ferritin. Nanoscale, 13, 2021
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6TXH
| Crystal structure of thermotoga maritima Ferritin in apo form | Descriptor: | EICOSANE, Ferritin, GLYCEROL, ... | Authors: | Wilk, P, Grudnik, P, Kumar, M, Heddle, J, Chakraborti, S. | Deposit date: | 2020-01-14 | Release date: | 2021-07-28 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.198 Å) | Cite: | A single residue can modulate nanocage assembly in salt dependent ferritin. Nanoscale, 13, 2021
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6TXM
| Crystal structure of thermotoga maritima E65R Ferritin | Descriptor: | EICOSANE, Ferritin, GLYCEROL, ... | Authors: | Wilk, P, Grudnik, P, Kumar, M, Heddle, J, Chakraborti, S. | Deposit date: | 2020-01-14 | Release date: | 2021-07-28 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.198 Å) | Cite: | A single residue can modulate nanocage assembly in salt dependent ferritin. Nanoscale, 13, 2021
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6TXL
| Crystal structure of thermotoga maritima E65Q Ferritin | Descriptor: | EICOSANE, FE (III) ION, Ferritin, ... | Authors: | Wilk, P, Grudnik, P, Kumar, M, Heddle, J, Chakraborti, S. | Deposit date: | 2020-01-14 | Release date: | 2021-07-28 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.099 Å) | Cite: | A single residue can modulate nanocage assembly in salt dependent ferritin. Nanoscale, 13, 2021
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6TXJ
| Crystal structure of thermotoga maritima A42V E65D Ferritin | Descriptor: | EICOSANE, FE (III) ION, Ferritin, ... | Authors: | Wilk, P, Grudnik, P, Kumar, M, Heddle, J, Chakraborti, S, Biela, A.P. | Deposit date: | 2020-01-14 | Release date: | 2021-07-28 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.17 Å) | Cite: | A single residue can modulate nanocage assembly in salt dependent ferritin. Nanoscale, 13, 2021
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6TXK
| Crystal structure of thermotoga maritima E65K Ferritin | Descriptor: | EICOSANE, FE (III) ION, Ferritin, ... | Authors: | Wilk, P, Grudnik, P, Kumar, M, Heddle, J, Chakraborti, S. | Deposit date: | 2020-01-14 | Release date: | 2021-07-28 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.359 Å) | Cite: | A single residue can modulate nanocage assembly in salt dependent ferritin. Nanoscale, 13, 2021
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6TXI
| Crystal structure of thermotoga maritima E65A Ferritin | Descriptor: | EICOSANE, FE (III) ION, Ferritin, ... | Authors: | Wilk, P, Grudnik, P, Kumar, M, Heddle, J, Chakraborti, S. | Deposit date: | 2020-01-14 | Release date: | 2021-07-28 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.759 Å) | Cite: | A single residue can modulate nanocage assembly in salt dependent ferritin. Nanoscale, 13, 2021
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6ZQ8
| Crystal structure of Chaetomium thermophilum Glycerol Kinase in P3221 space group | Descriptor: | Glycerol kinase-like protein | Authors: | Wilk, P, Wator, E, Malecki, P, Tokarz, P, Grudnik, P. | Deposit date: | 2020-07-09 | Release date: | 2020-12-23 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Structural Characterization of Glycerol Kinase from the Thermophilic Fungus Chaetomium thermophilum . Int J Mol Sci, 21, 2020
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6ZQ6
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6ZQ7
| Crystal structure of Chaetomium thermophilum Glycerol Kinase in I222 space group | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, Glycerol kinase-like protein | Authors: | Wilk, P, Wator, E, Grudnik, P. | Deposit date: | 2020-07-09 | Release date: | 2020-12-23 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.421 Å) | Cite: | Structural Characterization of Glycerol Kinase from the Thermophilic Fungus Chaetomium thermophilum . Int J Mol Sci, 21, 2020
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6ZQ4
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7A6S
| Crystal Structure of Asn173Ser variant of Human Deoxyhypusine Synthase | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, Deoxyhypusine synthase, ... | Authors: | Wator, E, Wilk, P, Grudnik, P. | Deposit date: | 2020-08-26 | Release date: | 2022-03-23 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders. Nat Commun, 14, 2023
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7A6T
| Crystal Structure of Asn173Ser variant of Human Deoxyhypusine Synthase in complex with NAD and spermidine | Descriptor: | 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, Deoxyhypusine synthase, ... | Authors: | Wator, E, Wilk, P, Grudnik, P. | Deposit date: | 2020-08-26 | Release date: | 2022-03-23 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders. Nat Commun, 14, 2023
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6XXH
| Crystal Structure of Human Deoxyhypusine Synthase in apo form | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, ACETATE ION, BETA-MERCAPTOETHANOL, ... | Authors: | Wator, E, Wilk, P, Grudnik, P. | Deposit date: | 2020-01-27 | Release date: | 2020-04-15 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | Half Way to Hypusine-Structural Basis for Substrate Recognition by Human Deoxyhypusine Synthase. Biomolecules, 10, 2020
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6XXL
| Crystal Structure of Human Deoxyhypusine Synthase in complex with spermine | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, ACETATE ION, ... | Authors: | Wator, E, Wilk, P, Grudnik, P. | Deposit date: | 2020-01-27 | Release date: | 2020-04-15 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Half Way to Hypusine-Structural Basis for Substrate Recognition by Human Deoxyhypusine Synthase. Biomolecules, 10, 2020
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6XXI
| Crystal Structure of Human Deoxyhypusine Synthase in complex with NAD | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, 1,2-ETHANEDIOL, ACETATE ION, ... | Authors: | Wator, E, Wilk, P, Grudnik, P. | Deposit date: | 2020-01-27 | Release date: | 2020-04-15 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.679 Å) | Cite: | Half Way to Hypusine-Structural Basis for Substrate Recognition by Human Deoxyhypusine Synthase. Biomolecules, 10, 2020
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