5N86
Crystal structure of FAS1 domain of hyaluronic acid receptor stabilin-2
Summary for 5N86
| Entry DOI | 10.2210/pdb5n86/pdb |
| Descriptor | Stabilin-2 (2 entities in total) |
| Functional Keywords | fas1 domain, hyaluronic acid receptor, stabilin-2, stab2, cell adhesion |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 31451.48 |
| Authors | Twarda-Clapa, A.,Labuzek, B.,Grudnik, P.,Dubin, G.,Holak, T.A. (deposition date: 2017-02-23, release date: 2018-06-27, Last modification date: 2024-01-17) |
| Primary citation | Twarda-Clapa, A.,Labuzek, B.,Krzemien, D.,Musielak, B.,Grudnik, P.,Dubin, G.,Holak, T.A. Crystal structure of the FAS1 domain of the hyaluronic acid receptor stabilin-2. Acta Crystallogr D Struct Biol, 74:695-701, 2018 Cited by PubMed Abstract: Recent research has identified a potential role of the hyaluronic acid receptor stabilin-2 (Stab2) in cancer metastasis. Stab2 belongs to a group of scavenger receptors and is responsible for the clearance of more than ten ligands, including hyaluronic acid (HA). In vivo experiments on mice have shown that the absence of Stab2, or its blocking by an antibody, effectively opposes cancer metastasis, which is accompanied by an increase in the level of circulating HA. Knowledge of ligand recognition and signal transduction by Stab2 is limited and no three-dimensional structures of any protein fragments of this receptor have been solved to date. Here, a high-resolution X-ray structure of the seventh FAS1 domain of Stab2 is reported. This structure provides the first insight into the Stab2 structure. PubMed: 29968679DOI: 10.1107/S2059798318007271 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.484 Å) |
Structure validation
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