8TKP
 
 | | Structure of the C. elegans TMC-2 complex | | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Clark, S, Jeong, H, Goehring, A, Posert, R, Gouaux, E. | | 登録日 | 2023-07-25 | | 公開日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | The structure of the Caenorhabditis elegans TMC-2 complex suggests roles of lipid-mediated subunit contacts in mechanosensory transduction.
Proc.Natl.Acad.Sci.USA, 121, 2024
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4NTX
 | | Structure of acid-sensing ion channel in complex with snake toxin and amiloride | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,5-DIAMINO-N-(AMINOIMINOMETHYL)-6-CHLOROPYRAZINECARBOXAMIDE, Acid-sensing ion channel 1, ... | | 著者 | Baconguis, I, Bohlen, C.J, Goehring, A, Julius, D, Gouaux, E. | | 登録日 | 2013-12-02 | | 公開日 | 2014-02-19 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | | 主引用文献 | X-ray structure of Acid-sensing ion channel 1-snake toxin complex reveals open state of a na(+)-selective channel.
Cell(Cambridge,Mass.), 156, 2014
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5UP2
 | | Triheteromeric NMDA receptor GluN1/GluN2A/GluN2B in complex with glycine, glutamate, Ro 25-6981, MK-801 and a GluN2B-specific Fab, at pH 6.5 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GluN2B-specific Fab, ... | | 著者 | Lu, W, Du, J, Goehring, A, Gouaux, E. | | 登録日 | 2017-02-01 | | 公開日 | 2017-03-22 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (6 Å) | | 主引用文献 | Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation.
Science, 355, 2017
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5UOW
 | | Triheteromeric NMDA receptor GluN1/GluN2A/GluN2B in complex with glycine, glutamate, MK-801 and a GluN2B-specific Fab, at pH 6.5 | | 分子名称: | (5S,10R)-5-methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, ... | | 著者 | Lu, W, Du, J, Goehring, A, Gouaux, E. | | 登録日 | 2017-02-01 | | 公開日 | 2017-03-22 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation.
Science, 355, 2017
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5IPT
 | | Cryo-EM structure of GluN1/GluN2B NMDA receptor in the DCKA/D-APV-bound conformation, state 5 | | 分子名称: | Ionotropic glutamate receptor subunit NR2B, N-methyl-D-aspartate receptor subunit NR1-8a | | 著者 | Zhu, S, Stein, A.R, Yoshioka, C, Lee, C.H, Goehring, A, Mchaourab, S.H, Gouaux, E. | | 登録日 | 2016-03-09 | | 公開日 | 2016-04-20 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (14.1 Å) | | 主引用文献 | Mechanism of NMDA Receptor Inhibition and Activation.
Cell, 165, 2016
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5IPS
 | | Cryo-EM structure of GluN1/GluN2B NMDA receptor in the DCKA/D-APV-bound conformation, state 4 | | 分子名称: | Ionotropic glutamate receptor subunit NR2B, N-methyl-D-aspartate receptor subunit NR1-8a | | 著者 | Zhu, S, Stein, A.R, Yoshioka, C, Lee, C.H, Goehring, A, Mchaourab, S.H, Gouaux, E. | | 登録日 | 2016-03-09 | | 公開日 | 2016-04-20 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (13.5 Å) | | 主引用文献 | Mechanism of NMDA Receptor Inhibition and Activation.
Cell, 165, 2016
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5IPR
 | | Cryo-EM structure of GluN1/GluN2B NMDA receptor in the DCKA/D-APV-bound conformation, state 3 | | 分子名称: | Ionotropic glutamate receptor subunit NR2B, N-methyl-D-aspartate receptor subunit NR1-8a | | 著者 | Zhu, S, Stein, A.R, Yoshioka, C, Lee, C.H, Goehring, A, Mchaourab, S.H, Gouaux, E. | | 登録日 | 2016-03-09 | | 公開日 | 2016-04-20 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (14.1 Å) | | 主引用文献 | Mechanism of NMDA Receptor Inhibition and Activation.
Cell, 165, 2016
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5IOU
 | | Cryo-EM structure of GluN1/GluN2B NMDA receptor in the glutamate/glycine-bound conformation | | 分子名称: | GLUTAMIC ACID, GLYCINE, Ionotropic glutamate receptor subunit NR2B, ... | | 著者 | Zhu, S, Stein, A.R, Yoshioka, C, Lee, C.H, Goehring, A, Mchaourab, S.H, Gouaux, E. | | 登録日 | 2016-03-09 | | 公開日 | 2016-04-20 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (7 Å) | | 主引用文献 | Mechanism of NMDA Receptor Inhibition and Activation.
Cell, 165, 2016
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5IPU
 | | Cryo-EM structure of GluN1/GluN2B NMDA receptor in the DCKA/D-APV-bound conformation, state 6 | | 分子名称: | Ionotropic glutamate receptor subunit NR2B, N-methyl-D-aspartate receptor subunit NR1-8a | | 著者 | Zhu, S, Stein, A.R, Yoshioka, C, Lee, C.H, Goehring, A, Mchaourab, S.H, Gouaux, E. | | 登録日 | 2016-03-09 | | 公開日 | 2016-04-20 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (15.4 Å) | | 主引用文献 | Mechanism of NMDA Receptor Inhibition and Activation.
Cell, 165, 2016
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5IOV
 | | Cryo-EM structure of GluN1/GluN2B NMDA receptor in the glutamate/glycine/Ro25-6981-bound conformation | | 分子名称: | 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol, GLUTAMIC ACID, GLYCINE, ... | | 著者 | Zhu, S, Stein, A.R, Yoshioka, C, Lee, C.H, Goehring, A, Mchaourab, S.H, Gouaux, E. | | 登録日 | 2016-03-09 | | 公開日 | 2016-04-20 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (7.5 Å) | | 主引用文献 | Mechanism of NMDA Receptor Inhibition and Activation.
Cell, 165, 2016
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5IPV
 | | Cryo-EM structure of GluN1/GluN2B NMDA receptor in the DCKA/D-APV-bound conformation, state 1 | | 分子名称: | Ionotropic glutamate receptor subunit NR2B, N-methyl-D-aspartate receptor subunit NR1-8a | | 著者 | Zhu, S, Stein, A.R, Yoshioka, C, Lee, C.H, Goehring, A, McHaourab, S.H, Gouaux, E. | | 登録日 | 2016-03-10 | | 公開日 | 2016-04-20 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (9.25 Å) | | 主引用文献 | Mechanism of NMDA Receptor Inhibition and Activation.
Cell, 165, 2016
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5IPQ
 | | Cryo-EM structure of GluN1/GluN2B NMDA receptor in the DCKA/D-APV-bound conformation, state 2 | | 分子名称: | Ionotropic glutamate receptor subunit NR2B, N-methyl-D-aspartate receptor subunit NR1-8a | | 著者 | Zhu, S, Stein, A.R, Yoshioka, C, Lee, C.H, Goehring, A, Mchaourab, S.H, Gouaux, E. | | 登録日 | 2016-03-09 | | 公開日 | 2016-04-20 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (13.5 Å) | | 主引用文献 | Mechanism of NMDA Receptor Inhibition and Activation.
Cell, 165, 2016
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4NTW
 | | Structure of acid-sensing ion channel in complex with snake toxin | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel 1, Basic phospholipase A2 homolog Tx-beta, ... | | 著者 | Baconguis, I, Bohlen, C.J, Goehring, A, Julius, D, Gouaux, E. | | 登録日 | 2013-12-02 | | 公開日 | 2014-02-19 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | | 主引用文献 | X-ray structure of Acid-sensing ion channel 1-snake toxin complex reveals open state of a na(+)-selective channel.
Cell(Cambridge,Mass.), 156, 2014
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4NTY
 | | Cesium sites in the crystal structure of acid-sensing ion channel in complex with snake toxin | | 分子名称: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Acid-sensing ion channel 1, Basic phospholipase A2 homolog Tx-beta, ... | | 著者 | Baconguis, I, Bohlen, C.J, Goehring, A, Julius, D, Gouaux, E. | | 登録日 | 2013-12-02 | | 公開日 | 2014-02-19 | | 最終更新日 | 2019-12-25 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | X-ray structure of Acid-sensing ion channel 1-snake toxin complex reveals open state of a na(+)-selective channel.
Cell(Cambridge,Mass.), 156, 2014
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3GI8
 | | Crystal Structure of ApcT K158A Transporter Bound to 7F11 Monoclonal Fab Fragment | | 分子名称: | 7F11 Anti-ApcT Monoclonal Fab Heavy Chain, 7F11 Anti-ApcT Monoclonal Fab Light Chain, Uncharacterized protein MJ0609 | | 著者 | Shaffer, P.L, Goehring, A.S, Shankaranarayanan, A, Gouaux, E, New York Consortium on Membrane Protein Structure (NYCOMPS) | | 登録日 | 2009-03-05 | | 公開日 | 2009-08-18 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | | 主引用文献 | Structure and mechanism of a na+-independent amino Acid transporter.
Science, 325, 2009
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3GIA
 | | Crystal Structure of ApcT Transporter | | 分子名称: | BICINE, DECANE, Uncharacterized protein MJ0609 | | 著者 | Shaffer, P.L, Goehring, A.S, Shankaranarayanan, A, Gouaux, E, New York Consortium on Membrane Protein Structure (NYCOMPS) | | 登録日 | 2009-03-05 | | 公開日 | 2009-08-18 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | | 主引用文献 | Structure and mechanism of a na+-independent amino Acid transporter.
Science, 325, 2009
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3GI9
 | | Crystal Structure of ApcT Transporter Bound to 7F11 Monoclonal Fab Fragment | | 分子名称: | 7F11 Anti-ApcT Monoclonal Fab Heavy Chain, 7F11 Anti-ApcT Monoclonal Fab Light Chain, Uncharacterized protein MJ0609 | | 著者 | Shaffer, P.L, Goehring, A.S, Shankaranarayanan, A, Gouaux, E, New York Consortium on Membrane Protein Structure (NYCOMPS) | | 登録日 | 2009-03-05 | | 公開日 | 2009-08-18 | | 最終更新日 | 2017-06-07 | | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | | 主引用文献 | Structure and mechanism of a na+-independent amino Acid transporter.
Science, 325, 2009
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6GMP
 | | CRYSTAL STRUCTURE OF THE PPIASE DOMAIN OF TBPAR42 | | 分子名称: | PARVULIN 42 | | 著者 | Hoenig, D, Rute, A, Hofmann, E, Bayer, P, Gasper, R. | | 登録日 | 2018-05-28 | | 公開日 | 2019-03-20 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Structural Analysis of the 42 kDa Parvulin ofTrypanosoma brucei.
Biomolecules, 9, 2019
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7USX
 | | Structure of Contracted C. elegans TMC-1 complex | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Jeong, H, Clark, S, Gouaux, E. | | 登録日 | 2022-04-26 | | 公開日 | 2022-10-19 | | 最終更新日 | 2023-08-09 | | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | | 主引用文献 | Structures of the TMC-1 complex illuminate mechanosensory transduction.
Nature, 610, 2022
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7USW
 | | Structure of Expanded C. elegans TMC-1 complex | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Jeong, H, Clark, S, Gouaux, E. | | 登録日 | 2022-04-26 | | 公開日 | 2022-10-19 | | 最終更新日 | 2023-08-09 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structures of the TMC-1 complex illuminate mechanosensory transduction.
Nature, 610, 2022
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7USY
 | | Structure of C. elegans TMC-1 complex with ARRD-6 | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Jeong, H, Clark, S, Gouaux, E. | | 登録日 | 2022-04-26 | | 公開日 | 2022-10-19 | | 最終更新日 | 2023-08-09 | | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | | 主引用文献 | Structures of the TMC-1 complex illuminate mechanosensory transduction.
Nature, 610, 2022
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2N84
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2N87
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4TLL
 | | Crystal structure of GluN1/GluN2B NMDA receptor, structure 1 | | 分子名称: | 1-AMINOCYCLOPROPANECARBOXYLIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol, ... | | 著者 | Gouaux, E, Lee, C.-H, Lu, W. | | 登録日 | 2014-05-30 | | 公開日 | 2014-07-02 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (3.59 Å) | | 主引用文献 | NMDA receptor structures reveal subunit arrangement and pore architecture.
Nature, 511, 2014
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4TLM
 | | Crystal structure of GluN1/GluN2B NMDA receptor, structure 2 | | 分子名称: | 1-AMINOCYCLOPROPANECARBOXYLIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol, ... | | 著者 | Gouaux, E, Lee, C.-H, Lu, W. | | 登録日 | 2014-05-30 | | 公開日 | 2014-07-02 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (3.77 Å) | | 主引用文献 | NMDA receptor structures reveal subunit arrangement and pore architecture.
Nature, 511, 2014
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