6NDZ
| Designed repeat protein in complex with Fz8 | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, ACETIC ACID, ... | 著者 | Miao, Y, Jude, K.M, Garcia, K.C. | 登録日 | 2018-12-14 | 公開日 | 2019-05-15 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.264 Å) | 主引用文献 | Receptor subtype discrimination using extensive shape complementary designed interfaces. Nat.Struct.Mol.Biol., 26, 2019
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6NE2
| Designed repeat protein in complex with Fz7 | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... | 著者 | Miao, Y, Jude, K.M, Garcia, K.C. | 登録日 | 2018-12-15 | 公開日 | 2019-05-15 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.299 Å) | 主引用文献 | Receptor subtype discrimination using extensive shape complementary designed interfaces. Nat.Struct.Mol.Biol., 26, 2019
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7TR4
| MA2-MART1-HLAA0201 | 分子名称: | Beta-2-microglobulin, GLYCEROL, HLA-A*02:01, ... | 著者 | Yang, X, Jude, K.M, Garcia, K.C. | 登録日 | 2022-01-27 | 公開日 | 2022-11-23 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Facile repurposing of peptide-MHC-restricted antibodies for cancer immunotherapy. Nat.Biotechnol., 41, 2023
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7N3T
| TrkA ECD complex with designed miniprotein ligand | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Jude, K.M, Cao, L, Garcia, K.C. | 登録日 | 2021-06-01 | 公開日 | 2022-04-20 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Design of protein-binding proteins from the target structure alone. Nature, 605, 2022
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6NE1
| Designed repeat protein in complex with Fz4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Frizzled-4, Pfs, ... | 著者 | Miao, Y, Jude, K.M, Garcia, K.C. | 登録日 | 2018-12-15 | 公開日 | 2019-05-15 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.011 Å) | 主引用文献 | Receptor subtype discrimination using extensive shape complementary designed interfaces. Nat.Struct.Mol.Biol., 26, 2019
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6NE4
| Designed repeat protein specifically in complex with Fz7CRD | 分子名称: | 1,2-ETHANEDIOL, Designed repeat binding protein, Frizzled-7, ... | 著者 | Miao, Y, Jude, K.M, Garcia, K.C. | 登録日 | 2018-12-16 | 公開日 | 2019-05-15 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.648 Å) | 主引用文献 | Receptor subtype discrimination using extensive shape complementary designed interfaces. Nat.Struct.Mol.Biol., 26, 2019
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1PVH
| Crystal structure of leukemia inhibitory factor in complex with gp130 | 分子名称: | IODIDE ION, Interleukin-6 receptor beta chain, Leukemia inhibitory factor | 著者 | Boulanger, M.J, Bankovich, A.J, Kortemme, T, Baker, D, Garcia, K.C. | 登録日 | 2003-06-27 | 公開日 | 2003-10-14 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130. Mol.Cell, 12, 2003
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1R5V
| Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T-cell activation | 分子名称: | H-2 class II histocompatibility antigen, E-K alpha chain, MHC H2-IE-beta, ... | 著者 | Krogsgaard, M, Prado, N, Adams, E.J, He, X.L, Chow, D.C, Wilson, D.B, Garcia, K.C, Davis, M.M. | 登録日 | 2003-10-13 | 公開日 | 2004-02-03 | 最終更新日 | 2021-10-27 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation. Mol.Cell, 12, 2003
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1R5W
| Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T-cell activation | 分子名称: | H-2 class II histocompatibility antigen, E-K alpha chain, MHC H2-IE-beta, ... | 著者 | Krogsgaard, M, Prado, N, Adams, E, He, X, Chow, D.C, Wilson, D.B, Garcia, K.C, Davis, M.M. | 登録日 | 2003-10-13 | 公開日 | 2004-03-02 | 最終更新日 | 2021-10-27 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation Mol.Cell, 12, 2003
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1SG1
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5E4E
| Engineered Interleukin-13 bound to receptor | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-13, Interleukin-13 receptor subunit alpha-1, ... | 著者 | Moraga, I, Thomas, C, Jude, K.M, Garcia, K.C. | 登録日 | 2015-10-05 | 公開日 | 2015-12-02 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency. Sci.Signal., 8, 2015
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1U3H
| Crystal structure of mouse TCR 172.10 complexed with MHC class II I-Au molecule at 2.4 A | 分子名称: | H-2 class II histocompatibility antigen, A-U alpha chain, A-U beta chain, ... | 著者 | Maynard, J, Petersson, K, Wilson, D.H, Adams, E.J, Blondelle, S.E, Boulanger, M.J, Wilson, D.B, Garcia, K.C. | 登録日 | 2004-07-21 | 公開日 | 2005-05-17 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | 主引用文献 | Structure of an autoimmune T cell receptor complexed with class II peptide-MHC: insights into MHC bias and antigen specificity Immunity, 22, 2005
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2IFG
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3IJ2
| Ligand-receptor structure | 分子名称: | Beta-nerve growth factor, Nerve growth factor receptor (TNFR superfamily, member 16) | 著者 | Feng, D, Garcia, K.C. | 登録日 | 2009-08-03 | 公開日 | 2010-01-12 | 最終更新日 | 2021-10-13 | 実験手法 | X-RAY DIFFRACTION (3.75 Å) | 主引用文献 | Molecular and structural insight into proNGF engagement of p75NTR and sortilin. J.Mol.Biol., 396, 2010
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3JVF
| Crystal structure of an Interleukin-17 receptor complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Ely, L.K, Garcia, K.C. | 登録日 | 2009-09-16 | 公開日 | 2009-10-20 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Structural basis of receptor sharing by interleukin 17 cytokines. Nat.Immunol., 10, 2009
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3LB6
| The structure of IL-13 in complex with IL-13Ralpha2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Interleukin-13, ... | 著者 | Lupardus, P.J, Garcia, K.C, Birnbaum, M.E. | 登録日 | 2010-01-07 | 公開日 | 2010-03-16 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Ralpha2. Structure, 18, 2010
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7R86
| Structure of mouse BAI1 (ADGRB1) in complex with mouse Nogo receptor (RTN4R) | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-AMINOBENZOIC ACID, ... | 著者 | Miao, Y, Jude, K.M, Garcia, K.C. | 登録日 | 2021-06-26 | 公開日 | 2021-11-10 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development. Cell, 184, 2021
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7R85
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7R84
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7RA9
| Designed StabIL-2 seq1 | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Interleukin-2, PHOSPHATE ION | 著者 | Jude, K.M, Chu, A.E, Huang, P.-S, Garcia, K.C. | 登録日 | 2021-06-30 | 公開日 | 2022-03-16 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Interleukin-2 superkines by computational design. Proc.Natl.Acad.Sci.USA, 119, 2022
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3E0G
| Structure of the Leukemia Inhibitory Factor Receptor (LIF-R) domains D1-D5 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Leukemia inhibitory factor receptor, ... | 著者 | Lupardus, P.J, Garcia, K.C. | 登録日 | 2008-07-31 | 公開日 | 2008-09-23 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structural organization of a full-length gp130/LIF-R cytokine receptor transmembrane complex. Mol.Cell, 31, 2008
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3DUH
| Structure of Interleukin-23 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 subunit beta, Interleukin-23 subunit alpha | 著者 | Lupardus, P.J, Garcia, K.C. | 登録日 | 2008-07-17 | 公開日 | 2008-08-19 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12. J.Mol.Biol., 382, 2008
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7S2S
| nanobody bound to Interleukin-2Rbeta | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, IL2Rb-binding nanobody, Interleukin-2 receptor subunit beta, ... | 著者 | Glassman, C.R, Jude, K.M, Yen, M, Garcia, K.C. | 登録日 | 2021-09-03 | 公開日 | 2022-03-30 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Facile discovery of surrogate cytokine agonists. Cell, 185, 2022
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7S2R
| nanobody bound to IL-2Rg | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit gamma, ... | 著者 | Glassman, C.R, Jude, K.M, Yen, M, Garcia, K.C. | 登録日 | 2021-09-03 | 公開日 | 2022-03-30 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | Facile discovery of surrogate cytokine agonists. Cell, 185, 2022
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4DEP
| Structure of the IL-1b signaling complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-1 beta, Interleukin-1 receptor accessory protein, ... | 著者 | Thomas, C, Garcia, K.C. | 登録日 | 2012-01-21 | 公開日 | 2012-03-21 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structure of the activating IL-1 receptor signaling complex. Nat.Struct.Mol.Biol., 19, 2012
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