1R5W

Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T-cell activation

Summary for 1R5W

DescriptorH-2 class II histocompatibility antigen, E-K alpha chain, MHC H2-IE-beta, artificial peptide (3 entities in total)
Functional Keywordstcr, mhc class ii, structural rearangement, signaling protein
Biological sourceMus musculus (house mouse)
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Cellular locationMembrane; Single-pass type I membrane protein (Potential) P04224
Total number of polymer chains6
Total molecular weight88320.59
Authors
Krogsgaard, M.,Prado, N.,Adams, E.,He, X.,Chow, D.C.,Wilson, D.B.,Garcia, K.C.,Davis, M.M. (deposition date: 2003-10-13, release date: 2004-03-02, Last modification date: 2011-07-13)
Primary citation
Krogsgaard, M.,Prado, N.,Adams, E.J.,He, X.L.,Chow, D.C.,Wilson, D.B.,Garcia, K.C.,Davis, M.M.
Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation
Mol.Cell, 12:1367-1378, 2003
PubMed: 14690592 (PDB entries with the same primary citation)
DOI: 10.1016/S1097-2765(03)00474-X
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.9 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers423.0%9.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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Molmil generated image of 1r5w
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