1KS0
 
 | | The First Fibronectin Type II Module from Human Matrix Metalloproteinase 2 | | Descriptor: | Matrix Metalloproteinase 2 | | Authors: | Gehrmann, M, Briknarova, K, Banyai, L, Patthy, L, Llinas, M. | | Deposit date: | 2002-01-10 | | Release date: | 2002-02-20 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | The col-1 module of human matrix metalloproteinase-2 (MMP-2): structural/functional relatedness between gelatin-binding fibronectin type II modules and lysine-binding kringle domains.
Biol.Chem., 383, 2002
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1VCW
 | | Crystal structure of DegS after backsoaking the activating peptide | | Descriptor: | Protease degS | | Authors: | Wilken, C, Kitzing, K, Kurzbauer, R, Ehrmann, M, Clausen, T. | | Deposit date: | 2004-03-16 | | Release date: | 2004-06-08 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (3.05 Å) | | Cite: | Crystal structure of the DegS stress sensor: How a PDZ domain recognizes misfolded protein and activates a protease.
Cell(Cambridge,Mass.), 117, 2004
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1KY9
 | | Crystal Structure of DegP (HtrA) | | Descriptor: | PROTEASE DO | | Authors: | Krojer, T, Garrido-Franco, M, Huber, R, Ehrmann, M, Clausen, T. | | Deposit date: | 2002-02-04 | | Release date: | 2002-04-03 | | Last modified: | 2021-10-27 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine.
Nature, 416, 2002
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3CS0
 | | Crystal structure of DegP24 | | Descriptor: | Periplasmic serine endoprotease DegP, pentapeptide | | Authors: | Krojer, T, Sawa, J, Schaefer, E, Saibil, H.R, Ehrmann, M, Clausen, T. | | Deposit date: | 2008-04-08 | | Release date: | 2008-05-27 | | Last modified: | 2019-11-13 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structural basis for the regulated protease and chaperone function of DegP
Nature, 453, 2008
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3NWU
 | | Substrate induced remodeling of the active site regulates HtrA1 activity | | Descriptor: | SULFATE ION, Serine protease HTRA1 | | Authors: | Truebestein, L, Tennstaedt, A, Hauske, P, Krojer, T, Kaiser, M, Clausen, T, Ehrmann, M. | | Deposit date: | 2010-07-11 | | Release date: | 2011-02-23 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Substrate-induced remodeling of the active site regulates human HTRA1 activity.
Nat.Struct.Mol.Biol., 18, 2011
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3NUM
 | | Substrate induced remodeling of the active site regulates HtrA1 activity | | Descriptor: | Serine protease HTRA1 | | Authors: | Truebestein, L, Tennstaedt, A, Hauske, P, Krojer, T, Kaiser, M, Clausen, T, Ehrmann, M. | | Deposit date: | 2010-07-07 | | Release date: | 2011-02-23 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Substrate-induced remodeling of the active site regulates human HTRA1 activity.
Nat.Struct.Mol.Biol., 18, 2011
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3NZI
 | | Substrate induced remodeling of the active site regulates HtrA1 activity | | Descriptor: | Citrate synthase, Serine protease HTRA1 | | Authors: | Truebestein, L, Tennstaedt, A, Hauske, P, Krojer, T, Kaiser, M, Clausen, T, Ehrmann, M. | | Deposit date: | 2010-07-16 | | Release date: | 2011-02-23 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Substrate-induced remodeling of the active site regulates human HTRA1 activity.
Nat.Struct.Mol.Biol., 18, 2011
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6Z0E
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6Z0Y
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6Z0X
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1SOZ
 | | Crystal Structure of DegS protease in complex with an activating peptide | | Descriptor: | Protease degS, activating peptide | | Authors: | Wilken, C, Kitzing, K, Kurzbauer, R, Ehrmann, M, Clausen, T. | | Deposit date: | 2004-03-16 | | Release date: | 2004-06-08 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of the DegS stress sensor: How a PDZ domain recognizes misfolded protein and activates a protease
Cell(Cambridge,Mass.), 117, 2004
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1SOT
 | | Crystal Structure of the DegS stress sensor | | Descriptor: | Protease degS | | Authors: | Wilken, C, Kitzing, K, Kurzbauer, R, Ehrmann, M, Clausen, T. | | Deposit date: | 2004-03-15 | | Release date: | 2004-06-08 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of the DegS stress sensor: How a PDZ domain recognizes misfolded protein and activates a protease
Cell(Cambridge,Mass.), 117, 2004
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4A8D
 | | DegP dodecamer with bound OMP | | Descriptor: | OUTER MEMBRANE PROTEIN C, PERIPLASMIC SERINE ENDOPROTEASE DEGP | | Authors: | Malet, H, Krojer, T, Sawa, J, Schafer, E, Saibil, H.R, Ehrmann, M, Clausen, T. | | Deposit date: | 2011-11-20 | | Release date: | 2012-01-11 | | Last modified: | 2017-08-30 | | Method: | ELECTRON MICROSCOPY (28 Å) | | Cite: | Newly Folded Substrates Inside the Molecular Cage of the Htra Chaperone Degq
Nat.Struct.Mol.Biol., 19, 2012
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3STJ
 | | Crystal structure of the protease + PDZ1 domain of DegQ from Escherichia coli | | Descriptor: | Protease degQ, peptide (UNK) | | Authors: | Sawa, J, Malet, H, Krojer, T, Canellas, F, Ehrmann, M, Clausen, T. | | Deposit date: | 2011-07-11 | | Release date: | 2011-07-27 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Molecular adaptation of the DegQ protease to exert protein quality control in the bacterial cell envelope.
J.Biol.Chem., 286, 2011
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3STI
 | | Crystal structure of the protease domain of DegQ from Escherichia coli | | Descriptor: | Protease degQ | | Authors: | Sawa, J, Malet, H, Krojer, T, Canellas, F, Ehrmann, M, Clausen, T. | | Deposit date: | 2011-07-11 | | Release date: | 2011-07-27 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Molecular adaptation of the DegQ protease to exert protein quality control in the bacterial cell envelope.
J.Biol.Chem., 286, 2011
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4A8A
 | | Asymmetric cryo-EM reconstruction of E. coli DegQ 12-mer in complex with lysozyme | | Descriptor: | LYSOZYME C, PERIPLASMIC PH-DEPENDENT SERINE ENDOPROTEASE DEGQ | | Authors: | Malet, H, Canellas, F, Sawa, J, Yan, J, Thalassinos, K, Ehrmann, M, Clausen, T, Saibil, H.R. | | Deposit date: | 2011-11-20 | | Release date: | 2011-12-28 | | Last modified: | 2017-08-23 | | Method: | ELECTRON MICROSCOPY (14.2 Å) | | Cite: | Newly Folded Substrates Inside the Molecular Cage of the Htra Chaperone Degq
Nat.Struct.Mol.Biol., 19, 2012
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4A9G
 | | Symmetrized cryo-EM reconstruction of E. coli DegQ 24-mer in complex with beta-casein | | Descriptor: | PERIPLASMIC PH-DEPENDENT SERINE ENDOPROTEASE DEGQ | | Authors: | Malet, H, Canellas, F, Sawa, J, Yan, J, Thalassinos, K, Ehrmann, M, Clausen, T, Saibil, H.R. | | Deposit date: | 2011-11-26 | | Release date: | 2012-01-11 | | Last modified: | 2017-08-23 | | Method: | ELECTRON MICROSCOPY (7.5 Å) | | Cite: | Newly Folded Substrates Inside the Molecular Cage of the Htra Chaperone Degq
Nat.Struct.Mol.Biol., 19, 2012
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4A8B
 | | Symmetrized cryo-EM reconstruction of E. coli DegQ 12-mer in complex with lysozymes | | Descriptor: | LYSOZYME C, PERIPLASMIC PH-DEPENDENT SERINE ENDOPROTEASE DEGQ | | Authors: | Malet, H, Canellas, F, Sawa, J, Yan, J, Thalassinos, K, Ehrmann, M, Clausen, T, Saibil, H.R. | | Deposit date: | 2011-11-20 | | Release date: | 2012-01-11 | | Last modified: | 2017-08-23 | | Method: | ELECTRON MICROSCOPY (13 Å) | | Cite: | Newly Folded Substrates Inside the Molecular Cage of the Htra Chaperone Degq
Nat.Struct.Mol.Biol., 19, 2012
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4A8C
 | | Symmetrized cryo-EM reconstruction of E. coli DegQ 12-mer in complex with a binding peptide | | Descriptor: | PERIPLASMIC PH-DEPENDENT SERINE ENDOPROTEASE DEGQ | | Authors: | Malet, H, Canellas, F, Sawa, J, Yan, J, Thalassinos, K, Ehrmann, M, Clausen, T, Saibil, H.R. | | Deposit date: | 2011-11-20 | | Release date: | 2012-01-11 | | Last modified: | 2017-08-30 | | Method: | ELECTRON MICROSCOPY (7.5 Å) | | Cite: | Newly Folded Substrates Inside the Molecular Cage of the Htra Chaperone Degq
Nat.Struct.Mol.Biol., 19, 2012
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1J7M
 | | The Third Fibronectin Type II Module from Human Matrix Metalloproteinase 2 | | Descriptor: | MATRIX METALLOPROTEINASE 2 | | Authors: | Briknarova, K, Gehrmann, M, Banyai, L, Tordai, H, Patthy, L, Llinas, M. | | Deposit date: | 2001-05-17 | | Release date: | 2001-05-30 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | Gelatin-binding region of human matrix metalloproteinase-2: solution structure, dynamics, and function of the COL-23 two-domain construct.
J.Biol.Chem., 276, 2001
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5TBE
 | | Human p38alpha MAP Kinase in Complex with Dibenzosuberone Compound 2 | | Descriptor: | Mitogen-activated protein kinase 14, ~{N}-[2,4-bis(fluoranyl)-5-[[9-(2-morpholin-4-ylethylcarbamoyl)-11-oxidanylidene-5,6-dihydrodibenzo[1,2-~{d}:1',2'-~{f}][7]annulen-3-yl]amino]phenyl]thiophene-2-carboxamide | | Authors: | Buehrmann, M, Rauh, D. | | Deposit date: | 2016-09-12 | | Release date: | 2017-04-19 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.44 Å) | | Cite: | Optimized Target Residence Time: Type I1/2 Inhibitors for p38 alpha MAP Kinase with Improved Binding Kinetics through Direct Interaction with the R-Spine.
Angew. Chem. Int. Ed. Engl., 56, 2017
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7OVM
 | | Protein kinase MKK7 in complex with cyclobutyl-substituted indazole | | Descriptor: | Dual specificity mitogen-activated protein kinase kinase 7, ~{N}-[(1-cyclobutyl-1,2,3-triazol-4-yl)methyl]-3-(1~{H}-indazol-3-yl)-5-(propanoylamino)benzamide | | Authors: | Buehrmann, M, Wiese, J.N, Mueller, M.P, Rauh, D. | | Deposit date: | 2021-06-15 | | Release date: | 2022-07-20 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Optimization of Covalent MKK7 Inhibitors via Crude Nanomole-Scale Libraries.
J.Med.Chem., 65, 2022
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7OVN
 | | Protein kinase MKK7 in complex with tolyl-substituted indazole | | Descriptor: | 3-(1~{H}-indazol-3-yl)-~{N}-[[1-(2-methylphenyl)-1,2,3-triazol-4-yl]methyl]-5-(propanoylamino)benzamide, Dual specificity mitogen-activated protein kinase kinase 7 | | Authors: | Buehrmann, M, Wiese, J.N, Mueller, M.P, Rauh, D. | | Deposit date: | 2021-06-15 | | Release date: | 2022-07-20 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Optimization of Covalent MKK7 Inhibitors via Crude Nanomole-Scale Libraries.
J.Med.Chem., 65, 2022
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7OVL
 | | Protein kinase MKK7 in complex with methoxycyclohexyl-substituted indazole | | Descriptor: | 3-(2~{H}-indazol-3-yl)-~{N}-[[1-[(1~{R},2~{R})-2-methoxycyclohexyl]-1,2,3-triazol-4-yl]methyl]-5-(propanoylamino)benzamide, Dual specificity mitogen-activated protein kinase kinase 7 | | Authors: | Buehrmann, M, Wiese, J.N, Mueller, M.P, Rauh, D. | | Deposit date: | 2021-06-15 | | Release date: | 2022-07-20 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Optimization of Covalent MKK7 Inhibitors via Crude Nanomole-Scale Libraries.
J.Med.Chem., 65, 2022
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5ML5
 | | Human p38alpha MAPK in complex with imidazolyl pyridine inhibitor 11b | | Descriptor: | 3-(2,5-dimethoxyphenyl)-~{N}-[4-[4-(4-fluorophenyl)-2-methylsulfanyl-1~{H}-imidazol-5-yl]pyridin-2-yl]propanamide, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside | | Authors: | Buehrmann, M, Rauh, D. | | Deposit date: | 2016-12-06 | | Release date: | 2017-04-05 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Optimized 4,5-Diarylimidazoles as Potent/Selective Inhibitors of Protein Kinase CK1 delta and Their Structural Relation to p38 alpha MAPK.
Molecules, 22, 2017
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