5TBE
Human p38alpha MAP Kinase in Complex with Dibenzosuberone Compound 2
Summary for 5TBE
Entry DOI | 10.2210/pdb5tbe/pdb |
Related | 5TCO |
Descriptor | Mitogen-activated protein kinase 14, ~{N}-[2,4-bis(fluoranyl)-5-[[9-(2-morpholin-4-ylethylcarbamoyl)-11-oxidanylidene-5,6-dihydrodibenzo[1,2-~{d}:1',2'-~{f}][7]annulen-3-yl]amino]phenyl]thiophene-2-carboxamide (3 entities in total) |
Functional Keywords | p38, kinase, inhibitor, complex, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : Q16539 |
Total number of polymer chains | 1 |
Total formula weight | 41959.87 |
Authors | Buehrmann, M.,Rauh, D. (deposition date: 2016-09-12, release date: 2017-04-19, Last modification date: 2024-01-17) |
Primary citation | Wentsch, H.K.,Walter, N.M.,Buhrmann, M.,Mayer-Wrangowski, S.,Rauh, D.,Zaman, G.J.R.,Willemsen-Seegers, N.,Buijsman, R.C.,Henning, M.,Dauch, D.,Zender, L.,Laufer, S. Optimized Target Residence Time: Type I1/2 Inhibitors for p38 alpha MAP Kinase with Improved Binding Kinetics through Direct Interaction with the R-Spine. Angew. Chem. Int. Ed. Engl., 56:5363-5367, 2017 Cited by PubMed: 28397331DOI: 10.1002/anie.201701185 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.44 Å) |
Structure validation
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