3NWU

Substrate induced remodeling of the active site regulates HtrA1 activity

Summary for 3NWU

Entry DOI	10.2210/pdb3nwu/pdb
Related	3NUM
Descriptor	Serine protease HTRA1, SULFATE ION (2 entities in total)
Functional Keywords	serine protease, degp, htra, protease, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Secreted: Q92743
Total number of polymer chains	3
Total formula weight	74917.37
Authors	Truebestein, L.,Tennstaedt, A.,Hauske, P.,Krojer, T.,Kaiser, M.,Clausen, T.,Ehrmann, M. (deposition date: 2010-07-11, release date: 2011-02-23, Last modification date: 2024-02-21)
Primary citation	Truebestein, L.,Tennstaedt, A.,Monig, T.,Krojer, T.,Canellas, F.,Kaiser, M.,Clausen, T.,Ehrmann, M. Substrate-induced remodeling of the active site regulates human HTRA1 activity. Nat.Struct.Mol.Biol., 18:386-388, 2011 Cited by PubMed: 21297635 DOI: 10.1038/nsmb.2013 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation