3NWU

Substrate induced remodeling of the active site regulates HtrA1 activity

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	Serine protease HTRA1	polymer	227	24876.4	3	UniProt (Q92743) Pfam (PF13365)	Homo sapiens (human)	L56, Serine protease 11
2	D, E, F (A, B, C)	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)

Sequence modifications

A, B, C: 158 - 375 (UniProt: Q92743)

PDB	External Database	Details
Met 157	-	initiating methionine
Leu 376	-	expression tag
Glu 377	-	expression tag
His 378	-	expression tag
His 379	-	expression tag
His 380	-	expression tag
His 381	-	expression tag
His 382	-	expression tag
His 383	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	74629.2
Non-Polymers*	Number of molecules	3
	Total formula weight	288.2
All*	Total formula weight	74917.4

*Water molecules are not included.