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5WHK
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BU of 5whk by Molmil
Crystal structure of Fab fragment of antibody DX-2507 bound to FcRn-B2M
分子名称: 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Beta-2-microglobulin, ...
著者Edwards, T.E, Clifton, M.C, Nixon, A.E, Kenniston, J.A.
登録日2017-07-17
公開日2017-09-06
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis for pH-insensitive inhibition of immunoglobulin G recycling by an anti-neonatal Fc receptor antibody.
J. Biol. Chem., 292, 2017
6AMY
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BU of 6amy by Molmil
Crystal structure of a 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase from Acinetobacter baumannii
分子名称: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
著者Seattle Structural Genomics Center for Infectious Disease, Edwards, T.E, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2017-08-11
公開日2017-09-06
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Crystal structure of a 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase from Acinetobacter baumannii
To Be Published
6UGK
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BU of 6ugk by Molmil
CRYSTAL STRUCTURE OF CIRCULARLY PERMUTED HUMAN TASPASE-1
分子名称: CHLORIDE ION, SODIUM ION, Threonine aspartase 1,Threonine aspartase 1
著者Edwards, T.E, Delker, S.L.
登録日2019-09-26
公開日2021-03-10
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural insights into the function of the catalytically active human Taspase1.
Structure, 29, 2021
6CTC
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BU of 6ctc by Molmil
Crystal structure of human transferrin bound to Triferic FPC iron pyrophosphate
分子名称: CARBONATE ION, FE (III) ION, PYROPHOSPHATE 2-, ...
著者Edwards, T.E, Pratt, R.
登録日2018-03-22
公開日2018-10-24
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Ferric pyrophosphate citrate: interactions with transferrin.
Biometals, 31, 2018
4OGX
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BU of 4ogx by Molmil
Crystal structure of Fab DX-2930 in complex with human plasma kallikrein at 2.4 Angstrom resolution
分子名称: DX-2930 HEAVY CHAIN, DX-2930 LIGHT CHAIN, Plasma kallikrein, ...
著者Edwards, T.E, Clifton, M.C, Abendroth, J, Nixon, A, Ladner, R.
登録日2014-01-16
公開日2014-07-09
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Inhibition of plasma kallikrein by a highly specific active site blocking antibody.
J.Biol.Chem., 289, 2014
4OBC
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BU of 4obc by Molmil
Crystal structure of HCV polymerase NS5b genotype 2a JFH-1 isolate with the S15G, C223H, V321I resistance mutations against the guanosine analog GS-0938 (PSI-3529238)
分子名称: 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, ...
著者Edwards, T.E, Abendroth, J, Appleby, T.C.
登録日2014-01-07
公開日2014-09-10
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Molecular and Structural Basis for the Roles of Hepatitis C Virus Polymerase NS5B Amino Acids 15, 223, and 321 in Viral Replication and Drug Resistance.
Antimicrob.Agents Chemother., 58, 2014
4OGY
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BU of 4ogy by Molmil
Crystal structure of Fab DX-2930 in complex with human plasma kallikrein at 2.1 Angstrom resolution
分子名称: 1,2-ETHANEDIOL, DX-2930 HEAVY CHAIN, DX-2930 LIGHT CHAIN, ...
著者Edwards, T.E, Clifton, M.C, Abendroth, J, Nixon, A, Ladner, R.
登録日2014-01-16
公開日2014-07-09
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Inhibition of plasma kallikrein by a highly specific active site blocking antibody.
J.Biol.Chem., 289, 2014
5IDU
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BU of 5idu by Molmil
Crystal structure of an acyl-CoA dehydrogenase domain protein from Burkholderia phymatum bound to FAD
分子名称: 1,2-ETHANEDIOL, Acyl-CoA dehydrogenase domain protein, FLAVIN-ADENINE DINUCLEOTIDE
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID), Edwards, T.E.
登録日2016-02-24
公開日2016-03-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Crystal structure of an acyl-CoA dehydrogenase domain protein from Burkholderia phymatum bound to FAD
To Be Published
4E7A
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BU of 4e7a by Molmil
Crystal structure of a product state assembly of HCV NS5B genotype 2a JFH-1 isolate with beta hairpin deletion bound to primer-template RNA with a 2',3'-ddC
分子名称: 5'-R(*CP*AP*UP*GP*GP*C)-D(P*(DOC))-3', RNA-directed RNA polymerase
著者Edwards, T.E, Mosley, R.T.
登録日2012-03-16
公開日2012-04-18
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure of hepatitis C virus polymerase in complex with primer-template RNA.
J.Virol., 86, 2012
4E76
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BU of 4e76 by Molmil
Apo crystal structure of HCV NS5B genotype 2A JFH-1 isolate with beta hairpin loop deletion
分子名称: 1,2-ETHANEDIOL, RNA-directed RNA polymerase, SULFATE ION
著者Edwards, T.E, Mosley, R.T.
登録日2012-03-16
公開日2012-04-18
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of hepatitis C virus polymerase in complex with primer-template RNA.
J.Virol., 86, 2012
4E78
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BU of 4e78 by Molmil
Crystal structure of a product state assembly of HCV NS5B genotype 2a JFH-1 isolate with beta hairpin loop deletion bound to primer-template RNA with 3'-dG
分子名称: 5'-R(*U*AP*CP*CP*GP*(GDO))-3', PROTEIN (RNA-directed RNA polymerase)
著者Edwards, T.E, Mosley, R.T.
登録日2012-03-16
公開日2012-04-18
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure of hepatitis C virus polymerase in complex with primer-template RNA.
J.Virol., 86, 2012
4EYE
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BU of 4eye by Molmil
Crystal structure of a probable oxidoreductase from Mycobacterium abscessus solved by iodide ion SAD
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, IODIDE ION, Probable oxidoreductase
著者Edwards, T.E, Abendroth, J, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2012-05-01
公開日2012-05-09
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Increasing the structural coverage of tuberculosis drug targets.
Tuberculosis (Edinb), 95, 2015
3IFT
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BU of 3ift by Molmil
Crystal structure of glycine cleavage system protein H from Mycobacterium tuberculosis, using X-rays from the Compact Light Source.
分子名称: Glycine cleavage system H protein
著者Edwards, T.E, Abendroth, J, Staker, B, Mayer, C, Phan, I, Kelley, A, Analau, E, Leibly, D, Rifkin, J, Loewen, R, Ruth, R.D, Stewart, L.J, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
登録日2009-07-25
公開日2009-08-11
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献X-ray structure determination of the glycine cleavage system protein H of Mycobacterium tuberculosis using an inverse Compton synchrotron X-ray source.
J.Struct.Funct.Genom., 11, 2010
5UJ2
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BU of 5uj2 by Molmil
Crystal structure of HCV NS5B genotype 2A JFH-1 isolate with S15G E86Q E87Q C223H V321I mutations and Delta8 neta hairpoin loop deletion in complex with GS-639476 (diphsohate version of GS-9813), Mn2+ and symmetrical primer template 5'-AUAAAUUU
分子名称: (1S)-1-(4-aminoimidazo[2,1-f][1,2,4]triazin-7-yl)-1,4-anhydro-2-deoxy-2-fluoro-5-O-[(S)-hydroxy(phosphonooxy)phosphoryl]-2-methyl-D-ribitol, CHLORIDE ION, Genome polyprotein, ...
著者Edwards, T.E, Fox III, D, Appleby, T.C, Murakami, E, Rey, A, McGrath, M.E.
登録日2017-01-16
公開日2017-03-22
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties.
Bioorg. Med. Chem. Lett., 27, 2017
5WHJ
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BU of 5whj by Molmil
Crystal structure of Fab fragment of anti-FcRn antibody DX-2507
分子名称: DX-2507 Fab heavy chain, DX-2507 Fab light chain
著者Edwards, T.E, Fairman, J.W, Nixon, A.E, Kenniston, J.A.
登録日2017-07-17
公開日2017-09-06
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural basis for pH-insensitive inhibition of immunoglobulin G recycling by an anti-neonatal Fc receptor antibody.
J. Biol. Chem., 292, 2017
1T4N
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BU of 1t4n by Molmil
Solution structure of Rnt1p dsRBD
分子名称: Ribonuclease III
著者Leulliot, N, Quevillon-Cheruel, S, Graille, M, van Tilbeurgh, H, Leeper, T.C, Godin, K.S, Edwards, T.E, Sigurdsson, S.T, Rozenkrants, N, Nagel, R.J, Ares, M, Varani, G.
登録日2004-04-30
公開日2004-07-13
最終更新日2021-11-03
実験手法SOLUTION NMR
主引用文献A new alpha-helical extension promotes RNA binding by the dsRBD of Rnt1p RNAse III
Embo J., 23, 2004
1T4O
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BU of 1t4o by Molmil
Crystal structure of rnt1p dsRBD
分子名称: Ribonuclease III
著者Leulliot, N, Quevillon-Cheruel, S, Graille, M, van Tilbeurgh, H, Leeper, T.C, Godin, K.S, Edwards, T.E, Sigurdsson, S.T, Rozenkrants, N, Nagel, R.J, Ares Jr, M, Varani, G.
登録日2004-04-30
公開日2004-06-22
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献A new alpha-helical extension promotes RNA binding by the dsRBD of Rnt1p RNAse III
Embo J., 23, 2004
1MX3
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BU of 1mx3 by Molmil
Crystal structure of CtBP dehydrogenase core holo form
分子名称: ACETIC ACID, C-terminal binding protein 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Kumar, V, Carlson, J.E, Ohgi, K.E, Edwards, T.E, Rose, D.W, Escalante, C.R, Aggarwal, A.K.
登録日2002-10-01
公開日2002-12-18
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Transcription Corepressor CtBP Is an NAD+-Regulated Dehydrogenase
Mol.Cell, 10, 2002
8DGD
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BU of 8dgd by Molmil
Crystal Structure of GAF domain-containing protein, from Klebsiella pneumoniae
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GAF domain-containing protein, ZINC ION
著者Seattle Structural Genomics Center for Infectious Disease, Delker, S.L, Weiss, M.J, Lorimer, D.D, Edwards, T.E, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2022-06-23
公開日2023-03-01
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal Structure of GAF domain-containing protein, from Klebsiella pneumoniae
to be published
5K85
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BU of 5k85 by Molmil
Crystal Structure of Acetyl-CoA Synthetase in Complex with Adenosine-5'-propylphosphate and Coenzyme A from Cryptococcus neoformans H99
分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-MONOPHOSPHATE-PROPYL ESTER, Acetyl-coenzyme A synthetase, ...
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID), Fox III, D, Delker, S.L, Potts, K.T, Lorimer, D.D, Edwards, T.E, Mutz, M.W, SSGCID
登録日2016-05-27
公開日2016-08-17
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献CRYSTAL STRUCTURE OF ACETYL-COA SYNTHETASE IN COMPLEX WITH ADENOSINE-5'-PROPYLPHOSPHATE AND COENZYME A FROM CRYPTOCOCCUS NEOFORMANS H99
To Be Published
5K8F
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BU of 5k8f by Molmil
Crystal structure of Acetyl-CoA Synthetase in complex with ATP and Acetyl-AMP from Cryptococcus neoformans H99
分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, Acetyl-coenzyme A synthetase, ...
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID), Fox III, D, Delker, S.L, Potts, K.T, Lorimer, D.D, Edwards, T.E, Mutz, M.W.
登録日2016-05-30
公開日2016-07-13
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Crystal structure of Acetyl-CoA Synthetase in complex with ATP and Acetyl-AMP from Cryptococcus neoformans H99
To Be Published
5KLX
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BU of 5klx by Molmil
Crystal Structure of SMT Fusion Peptidyl-Prolyl Cis-Trans Isomerase from Burkholderia Pseudomallei Complexed with SF110
分子名称: 2-[(2~{S})-1-(phenylmethyl)sulfonylpiperidin-2-yl]carbonyloxyethyl pyridine-3-carboxylate, Chimera protein of Ubiquitin-like protein SMT3 and Peptidyl-prolyl cis-trans isomerase, DI(HYDROXYETHYL)ETHER, ...
著者Fox III, D, Edwards, T.E.
登録日2016-06-26
公開日2017-05-31
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Crystal Structure of SMT Fusion Peptidyl-Prolyl Cis-Trans Isomerase from Burkholderia Pseudomallei Complexed with SF110
To Be Published
4WHX
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BU of 4whx by Molmil
X-ray Crystal Structure of an Amino Acid Aminotransferase from Burkholderia pseudomallei Bound to the Co-factor Pyridoxal Phosphate
分子名称: 1,2-ETHANEDIOL, ALANINE, Branched-chain-amino-acid transaminase
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID), Fairman, J.W, Dranow, D.M, Taylor, B.M, Lorimer, D, Edwards, T.E.
登録日2014-09-23
公開日2014-10-08
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献X-ray Crystal Structure of an Amino Acid Aminotransferase from Burkholderia pseudomallei Bound to the Co-factor Pyridoxal Phosphate
to be published
4WJB
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BU of 4wjb by Molmil
X-ray crystal structure of a putative amidohydrolase/peptidase from Burkholderia cenocepacia
分子名称: 1,2-ETHANEDIOL, Putative amidohydrolase/peptidase, SULFATE ION, ...
著者Lukacs, C.M, Dranow, D.M, Edwards, T.E, Lorimer, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2014-09-29
公開日2014-10-08
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献X-ray crystal structure of a putative amidohydrolase/peptidase from Burkholderia cenocepacia
To Be Published
6X9F
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BU of 6x9f by Molmil
Pseudomonas aeruginosa MurC with AZ8074
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
著者Horanyi, P.S, Mayclin, S.J, Durand-Reville, T.F, Lorimer, D.D, Edwards, T.E, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2020-06-02
公開日2020-09-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Pseudomonas aeruginosa MurC with AZ8074
To Be Published

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件を2024-05-15に公開中

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