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1JBU
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BU of 1jbu by Molmil
Coagulation Factor VII Zymogen (EGF2/Protease) in Complex with Inhibitory Exosite Peptide A-183
分子名称: BENZAMIDINE, COAGULATION FACTOR VII, Peptide exosite inhibitor A-183, ...
著者Eigenbrot, C, Kirchhofer, D, Dennis, M.S, Santell, L, Lazarus, R.A, Stamos, J, Ultsch, M.H.
登録日2001-06-06
公開日2001-07-11
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The factor VII zymogen structure reveals reregistration of beta strands during activation.
Structure, 9, 2001
1N4Y
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BU of 1n4y by Molmil
REFINED STRUCTURE OF KISTRIN
分子名称: KISTRIN
著者Krezel, A.M, Krane, J, Dennis, M.S, Lazarus, R.A, Wagner, G.
登録日2002-11-02
公開日2003-01-28
最終更新日2012-09-05
実験手法SOLUTION NMR
主引用文献Solution structure of kistrin, a potent platelet aggregation inhibitor and GP IIb-IIIa antagonist.
Science, 253, 1991
1DVA
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Crystal Structure of the Complex Between the Peptide Exosite Inhibitor E-76 and Coagulation Factor VIIA
分子名称: CACODYLATE ION, CALCIUM ION, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-phenylalaninamide, ...
著者Eigenbrot, C, Ultsch, M.H.
登録日2000-01-20
公開日2000-05-12
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Peptide exosite inhibitors of factor VIIa as anticoagulants.
Nature, 404, 2000
8G0M
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Structure of complex between TV6.6 and CD98hc ECD
分子名称: 1,2-ETHANEDIOL, 4F2 cell-surface antigen heavy chain, TETRAETHYLENE GLYCOL, ...
著者Kariolis, M.S, Lexa, K, Liau, N.P.D, Srivastava, D, Tran, H, Wells, R.C.
登録日2023-01-31
公開日2023-10-18
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献CD98hc is a target for brain delivery of biotherapeutics.
Nat Commun, 14, 2023
3HR5
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BU of 3hr5 by Molmil
M1prime peptide from IgE bound by humanized antibody 47H4 Fab
分子名称: Fab h47H4 heavy chain, Fab h47H4 light chain, GLYCEROL, ...
著者Eigenbrot, C.W, Ultsch, M.H.
登録日2009-06-08
公開日2010-05-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice.
J.Clin.Invest., 120, 2010
6W3H
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Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ATV Fc, Transferrin receptor protein 1,Transferrin receptor protein 1
著者Srivastava, A, Kariolis, M, Wells, R.
登録日2020-03-09
公開日2020-06-10
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.38 Å)
主引用文献Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys.
Sci Transl Med, 12, 2020
4K3J
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Crystal structure of Onartuzumab Fab in complex with MET and HGF-beta
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Hepatocyte growth factor, Hepatocyte growth factor beta chain, ...
著者Ma, X, Starovasnik, M.A.
登録日2013-04-10
公開日2013-08-28
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent.
Proc.Natl.Acad.Sci.USA, 110, 2013
6O1F
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Complex between soybean trypsin inhibitor beta1-tryptase and a humanized fab
分子名称: 1,2-ETHANEDIOL, Heavy Chain hu31A.v11, Light Chain hu31A.v11, ...
著者Ultsch, M.H, Yi, T.
登録日2019-02-19
公開日2019-10-16
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma.
Cell, 179, 2019
6VVU
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Anti-Tryptase fab E104.v1 bound to tryptase
分子名称: CALCIUM ION, Fab E104.v1 heavy chain, Fab E104.v1 light chain, ...
著者Ultsch, M, Koerber, J.T.
登録日2020-02-18
公開日2020-12-30
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Bivalent antibody pliers inhibit beta-tryptase by an allosteric mechanism dependent on the IgG hinge.
Nat Commun, 11, 2020

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