5FPO
| Structure of Bacterial DNA Ligase with small-molecule ligand 1H- indazol-7-amine (AT4213) in an alternate binding site. | 分子名称: | 1H-indazol-7-amine, DNA LIGASE | 著者 | Jhoti, H, Ludlow, R.F, Pathuri, P, Saini, H.K, Tickle, I.J, Tisi, D, Verdonk, M, Williams, P.A. | 登録日 | 2015-12-02 | 公開日 | 2015-12-23 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Detection of Secondary Binding Sites in Proteins Using Fragment Screening. Proc.Natl.Acad.Sci.USA, 112, 2015
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8JHO
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7M16
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2LF3
| Solution NMR structure of HopPmaL_281_385 from Pseudomonas syringae pv. maculicola str. ES4326, Midwest Center for Structural Genomics target APC40104.5 and Northeast Structural Genomics Consortium target PsT2A | 分子名称: | Effector protein hopAB3 | 著者 | Wu, B, Yee, A, Houliston, S, Semesi, A, Garcia, M, Singer, A.U, Savchenko, A, Montelione, G.T, Joachimiak, A, Arrowsmith, C.H, Northeast Structural Genomics Consortium (NESG), Midwest Center for Structural Genomics (MCSG), Ontario Centre for Structural Proteomics (OCSP) | 登録日 | 2011-06-28 | 公開日 | 2011-07-13 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural Analysis of HopPmaL Reveals the Presence of a Second Adaptor Domain Common to the HopAB Family of Pseudomonas syringae Type III Effectors. Biochemistry, 51, 2012
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2LF6
| Solution NMR structure of HopABPph1448_220_320 from Pseudomonas syringae pv. phaseolicola str. 1448A, Midwest Center for Structural Genomics target APC40132.4 and Northeast Structural Genomics Consortium target PsT3A | 分子名称: | Effector protein hopAB1 | 著者 | Wu, B, Yee, A, Houliston, S, Semesi, A, Garcia, M, Singer, A.U, Savchenko, A, Montelione, G.T, Joachimiak, A, Arrowsmith, C.H, Northeast Structural Genomics Consortium (NESG), Midwest Center for Structural Genomics (MCSG), Ontario Centre for Structural Proteomics (OCSP) | 登録日 | 2011-06-28 | 公開日 | 2011-07-13 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural Analysis of HopPmaL Reveals the Presence of a Second Adaptor Domain Common to the HopAB Family of Pseudomonas syringae Type III Effectors. Biochemistry, 51, 2012
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2M2J
| Solution NMR structure of the N-terminal domain of STM1478 from Salmonella typhimurium LT2: Target STR147A of the Northeast Structural Genomics consortium (NESG), and APC101565 of the Midwest Center for Structural Genomics (MCSG). | 分子名称: | Putative periplasmic protein | 著者 | Houliston, S, Yee, A, Lemak, A, Garcia, M, Wu, B, Savchenko, A, Montelione, G.T, Arrowsmith, C, Northeast Structural Genomics Consortium (NESG), Midwest Center for Structural Genomics (MCSG) | 登録日 | 2012-12-21 | 公開日 | 2013-05-08 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural and Functional Characterization of DUF1471 Domains of Salmonella Proteins SrfN, YdgH/SssB, and YahO. Plos One, 9, 2014
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2MA8
| Solution NMR Structure of Salmonella typhimurium LT2 Secreted Protein SrfN: Northeast Structural Genomics Consortium Target StR109 | 分子名称: | Putative secreted protein | 著者 | Cort, J.R, Eletsky, A, Adkins, J.N, Burnet, M.C, Parish, D, Liu, K, Sukumaran, D.K, Jiang, M, Cunningham, K, Ma, T, Xiao, R, Rost, B, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2013-06-29 | 公開日 | 2013-09-04 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural and Functional Characterization of DUF1471 Domains of Salmonella Proteins SrfN, YdgH/SssB, and YahO. Plos One, 9, 2014
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3H2Y
| Crystal structure of YqeH GTPase from Bacillus anthracis with dGDP bound | 分子名称: | 2'-DEOXYGUANOSINE-5'-DIPHOSPHATE, GTPase family protein | 著者 | Brunzelle, J.S, Anderson, S.M, Xu, X, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2009-04-15 | 公開日 | 2009-06-16 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structure of YqeH GTPase from Bacillus anthracis with dGDP Bound To be Published
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5JD6
| Crystal structure of MGS-MChE2, an alpha/beta hydrolase enzyme from the metagenome of sediments from the lagoon of Mar Chica, Morocco | 分子名称: | MGS-MChE2 | 著者 | Stogios, P.J, Xu, X, Nocek, B, Yim, V, Cui, H, Martinez-Martinez, M, Golyshin, P.N, Yakima, M.M, Ferrer, M, Savchenko, A. | 登録日 | 2016-04-15 | 公開日 | 2016-05-04 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.463 Å) | 主引用文献 | Crystal structure of MGS-MChE2, an alpha/beta hydrolase enzyme from the metagenome of sediments from the lagoon of Mar Chica, Morocco To Be Published
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6MH7
| Crystal structure of the first bromodomain of human BRD4 in complex with SKT-68, a 1,4,5-trisubstituted imidazole analogue | 分子名称: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, DIMETHYL SULFOXIDE, ... | 著者 | Zhu, J.-Y, Schonbrunn, E. | 登録日 | 2018-09-17 | 公開日 | 2019-08-07 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Molecular Basis for the N-Terminal Bromodomain-and-Extra-Terminal-Family Selectivity of a Dual Kinase-Bromodomain Inhibitor. J.Med.Chem., 61, 2018
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6MH1
| CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH HU-10, A 1,4,5-Trisubstituted Imidazole Analogue | 分子名称: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, N-(3,5-dimethylphenyl)-4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl]pyrimidin-2-amine | 著者 | Zhu, J.-Y, Schonbrunn, E. | 登録日 | 2018-09-17 | 公開日 | 2019-08-07 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Molecular Basis for the N-Terminal Bromodomain-and-Extra-Terminal-Family Selectivity of a Dual Kinase-Bromodomain Inhibitor. J.Med.Chem., 61, 2018
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6O3P
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3FTT
| Crystal Structure of the galactoside O-acetyltransferase from Staphylococcus aureus | 分子名称: | Putative acetyltransferase SACOL2570 | 著者 | Knapik, A.A, Shumilin, I.A, Cui, H, Xu, X, Chruszcz, M, Zimmerman, M.D, Cymborowski, M, Anderson, W.F, Savchenko, A, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2009-01-13 | 公開日 | 2009-03-03 | 最終更新日 | 2022-04-13 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Biophysical analysis of the putative acetyltransferase SACOL2570 from methicillin-resistant Staphylococcus aureus. J.Struct.Funct.Genom., 14, 2013
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1ZUO
| Structure of Human Ubiquitin-Conjugating Enzyme (UBCi) Involved in Embryo Attachment and Implantation | 分子名称: | BETA-MERCAPTOETHANOL, Hypothetical protein LOC92912 | 著者 | Walker, J.R, Avvakumov, G.V, Cui, H, Newman, E.M, Mackenzie, F, Sundstrom, M, Arrowsmith, C, Edwards, A, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | 登録日 | 2005-05-31 | 公開日 | 2005-07-05 | 最終更新日 | 2012-11-28 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen. Mol Cell Proteomics, 11, 2012
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8HIH
| Cryo-EM structure of Mycobacterium tuberculosis transcription initiation complex with transcription factor GlnR | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Lin, W, Shi, J, Xu, J.C. | 登録日 | 2022-11-20 | 公開日 | 2023-06-07 | 実験手法 | ELECTRON MICROSCOPY (3.66 Å) | 主引用文献 | Structural insights into the transcription activation mechanism of the global regulator GlnR from actinobacteria. Proc.Natl.Acad.Sci.USA, 120, 2023
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8HML
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3CQV
| Crystal structure of Reverb beta in complex with heme | 分子名称: | Nuclear receptor subfamily 1 group D member 2, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Xu, X, Dong, A, Pardee, K.I, Reinking, J, Krause, H, Schuetz, A, Zhang, R, Cui, H, Edwards, A, Arrowsmith, C.H, Weigelt, J, Bountra, C, Savchenko, A, Botchkarev, A, Structural Genomics Consortium (SGC) | 登録日 | 2008-04-03 | 公開日 | 2008-08-05 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The structural basis of gas-responsive transcription by the human nuclear hormone receptor REV-ERBbeta. Plos Biol., 7, 2009
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4HFV
| Crystal structure of lpg1851 protein from Legionella pneumophila (putative T4SS effector) | 分子名称: | CITRIC ACID, SUCCINIC ACID, Uncharacterized protein | 著者 | Michalska, K, Xu, X, Cui, H, Savchenko, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2012-10-05 | 公開日 | 2012-11-07 | 最終更新日 | 2017-01-04 | 実験手法 | X-RAY DIFFRACTION (1.901 Å) | 主引用文献 | Diverse mechanisms of metaeffector activity in an intracellular bacterial pathogen, Legionella pneumophila. Mol Syst Biol, 12, 2016
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4I3F
| Crystal structure of serine hydrolase CCSP0084 from the polyaromatic hydrocarbon (PAH)-degrading bacterium Cycloclasticus zankles | 分子名称: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, SODIUM ION, ... | 著者 | Stogios, P.J, Xu, X, Dong, A, Cui, H, Alcaide, M, Tornes, J, Gertler, C, Yakimov, M.M, Golyshin, P.N, Ferrer, M, Savchenko, A. | 登録日 | 2012-11-26 | 公開日 | 2013-06-26 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Single residues dictate the co-evolution of dual esterases: MCP hydrolases from the alpha / beta hydrolase family. Biochem.J., 454, 2013
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7EKB
| Crystal structure of 4E10 modified with pyrene acetamide | 分子名称: | ACETATE ION, Fab region of the heavy chain of broadly neutralizing antibody anti-HIV-1 4E10, Fab region of the light chain of the broadly neutralizing anti-HIV-1 antibody 4E10, ... | 著者 | Caaveiro, J.M.M, Rujas, E, Nieva, J.L. | 登録日 | 2021-04-05 | 公開日 | 2021-08-11 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile. Iscience, 24, 2021
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7EKK
| Anti-HIV-1 broadly neutralizing antibody delta-loop 4E10 modified with pyrene acetamide | 分子名称: | AMMONIUM ION, CHLORIDE ION, GLYCEROL, ... | 著者 | Caaveiro, J.M.M, Rujas, E, Nieva, J.L. | 登録日 | 2021-04-05 | 公開日 | 2021-08-11 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile. Iscience, 24, 2021
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7JOO
| Crystal structure of ICOS in complex with antibody STIM003 and anti-kappa VHH domain | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Inducible T-cell costimulator, ... | 著者 | Rujas, E, Sicard, T, Julien, J.P. | 登録日 | 2020-08-06 | 公開日 | 2020-10-14 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies. Nat Commun, 11, 2020
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2Z5D
| Human ubiquitin-conjugating enzyme E2 H | 分子名称: | SODIUM ION, Ubiquitin-conjugating enzyme E2 H | 著者 | Bochkarev, A, Cui, H, Walker, J.R, Newman, E.M, Mackenzie, F, Battaile, K.P, Sundstrom, M, Arrowsmith, C, Edwards, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | 登録日 | 2007-07-06 | 公開日 | 2007-10-09 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen. MOL.CELL PROTEOMICS, 11, 2012
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6AND
| Pinatuzumab Fab in complex with anti-Kappa VHH domain | 分子名称: | Anti-kappa VHH domain, GLYCEROL, Pinatuzumab Fab Heavy chain, ... | 著者 | Ereno-Orbea, J, Sicard, T, Julien, J.-P. | 登録日 | 2017-08-12 | 公開日 | 2018-01-31 | 最終更新日 | 2019-05-08 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structural Basis of Enhanced Crystallizability Induced by a Molecular Chaperone for Antibody Antigen-Binding Fragments. J. Mol. Biol., 430, 2018
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6ANI
| Coltuximab Fab in complex with anti-Kappa VHH domain | 分子名称: | Anti-Kappa VHH domain, Coltuximab Fab heavy chain, Coltuximab Fab light chain, ... | 著者 | Ereno Orbea, J, Sicard, T, Julien, J.-P. | 登録日 | 2017-08-13 | 公開日 | 2018-01-31 | 最終更新日 | 2019-10-16 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural Basis of Enhanced Crystallizability Induced by a Molecular Chaperone for Antibody Antigen-Binding Fragments. J. Mol. Biol., 430, 2018
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